Exploring the relationship of drug-induced neutrophil immaturity & haematological toxicity to drug chemistry using quantitative structure-activity models

Medicinal Chemistry

Volumn 5, Issue 1, 2009, Pages 7-14

  Delieu, J M ^a   Horobin, R W ^b   Duguid, J K ^c  

^a BANGOR UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c WREXHAM MAELOR HOSPITAL   (United Kingdom)

Author keywords

Agranulocytosis; Antipsychotics; Chlorpromazine; Clozapine; Neutropenia; Olanzapine; QSAR; Risk prediction

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; FLUPENTIXOL; FLUPHENAZINE; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PSYCHOTROPIC AGENT; RISPERIDONE; SULPIRIDE; THIORIDAZINE; TRIFLUOPERAZINE;

AGRANULOCYTOSIS; ARTICLE; BLOOD TOXICITY; CELL MATURATION; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; HUMAN; MAJOR CLINICAL STUDY; MITOCHONDRIAL MEMBRANE; NEUTROPENIA; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SCHIZOPHRENIA; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DRUG EFFECT; NEUTROPHIL;

AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENTS; ENDOPLASMIC RETICULUM; HUMANS; MITOCHONDRIAL MEMBRANES; NEUTROPENIA; NEUTROPHILS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62649172308     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340609787049307     Document Type: Article

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