Stimulation of erythrocyte phosphatidylserine exposure by chlorpromazine

European Journal of Pharmacology

Volumn 532, Issue 1-2, 2006, Pages 11-17

  Akel, Ahmad ^a   Hermle, Tobias ^a   Niemoeller, Olivier M ^a   Kempe, Daniela S ^a   Lang, Philipp A ^a   Attanasio, Philipp ^a   Podolski, Marlis ^a   Wieder, Thomas ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Apoptosis; Calcium; Cell volume; Cytosolic ATP; GSH (glutathione); Phosphatidylserine

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANNEXIN; CALCIUM ION; CHLORINE; CHLORPROMAZINE; GLUCOSE; GLUTATHIONE; NEUROLEPTIC AGENT; PHOSPHATIDYLSERINE;

ANEMIA; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL VOLUME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; ERYTHROCYTE KINETICS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; NORMAL HUMAN; OSMOTIC SHOCK; PRIORITY JOURNAL; PROTEIN BINDING; TOXICITY TESTING;

ADENOSINE TRIPHOSPHATE; ANTIPSYCHOTIC AGENTS; CALCIUM; CHLORIDES; CHLORPROMAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FLOW CYTOMETRY; GLUCOSE; GLUTATHIONE; HUMANS; HYPERTONIC SOLUTIONS; ISOTONIC SOLUTIONS; PHOSPHATIDYLSERINES;

EID: 33644510094     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.037     Document Type: Article

References (42)

1. H.A. Andree, C.P. Reutelingsperger, R. Hauptmann, H.C. Hemker, W.T. Hermens, and G.M. Willems Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers J. Biol. Chem. 265 1990 4923 4928
2. J.R. Babson, N.E. Gavitt, and J.M. Dougherty Chlorpromazine protection against Ca(2+)-dependent and oxidative cell injury. Limitations due to depressed mitochondrial function Biochem. Pharmacol. 48 1994 1509 1517
3. C.P. Berg, I.H. Engels, A. Rothbart, K. Lauber, A. Renz, S.F. Schlosser, K. Schulze-Osthoff, and S. Wesselborg Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis Cell Death Differ. 8 2001 1197 1206
4. C. Birka, P.A. Lang, D.S. Kempe, L. Hoefling, V. Tanneur, C. Duranton, S. Nammi, G. Henke, S. Myssina, M. Krikov, S.M. Huber, T. Wieder, and F. Lang Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion Pflugers Arch. 448 2004 471 477
5. F.E. Boas, L. Forman, and E. Beutler Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia Proc. Natl. Acad. Sci. U. S. A. 95 1998 3077 3081
6. R.M. Bookchin, O.E. Ortiz, and V.L. Lew Activation of calcium-dependent potassium channels in deoxygenated sickled red cells Prog. Clin. Biol. Res. 240 1987 193 200
7. G.J.C.G.M. Bosman, F.L.A. Willekens, and J.M. Werre Erythrocyte aging: a more than superficial resemblance to apoptosis? Cell Physiol. Biochem. 16 2005 1 8
8. V.B. Brand, C.D. Sandu, C. Duranton, V. Tanneur, K.S. Lang, S.M. Huber, and F. Lang Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte Cell Physiol. Biochem. 13 2003 347 356
9. D. Bratosin, J. Estaquier, F. Petit, D. Arnoult, B. Quatannens, J.P. Tissier, C. Slomianny, C. Sartiaux, C. Alonso, J.J. Huart, J. Montreuil, and J.C. Ameisen Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria Cell Death Differ. 8 2001 1143 1156
10. C. Brugnara, L. de Franceschi, and S.L. Alper Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives J. Clin. Invest. 92 1993 520 526
11. E. Daugas, C. Cande, and G. Kroemer Erythrocytes: death of a mummy Cell Death Differ. 8 2001 1131 1133
12. D.W. Dekkers, P. Comfurius, E.M. Bevers, and R.F. Zwaal Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells Biochem. J. 362 2002 741 747
13. P.G. Dorson, and M.L. Crismon Chlorpromazine accumulation and sudden death in a patient with renal insufficiency Drug Intell. Clin. Pharm. 22 1988 776 778
14. C. Duranton, S. Huber, V. Tanneur, K. Lang, V. Brand, C. Sandu, and F. Lang Electrophysiological properties of the Plasmodium falciparum-induced cation conductance of human erythrocytes Cell Physiol. Biochem. 13 2003 189 198
15. C. Duranton, S.M. Huber, and F. Lang Oxidation induces a Cl(-)-dependent cation conductance in human red blood cells J. Physiol. 539 2002 847 855
16. S. Eda, and I.W. Sherman Cytoadherence of malaria-infected red blood cells involves exposure of phosphatidylserine Cell Physiol. Biochem. 12 2002 373 384
17. S. Eskelinen The kinetics of drug-membrane interactions in human erythrocytes Can. J. Physiol. Pharmacol. 65 1987 2373 2378
18. V.A. Fadok, D.L. Bratton, D.M. Rose, A. Pearson, R.A. Ezekewitz, and P.M. Henson A receptor for phosphatidylserine-specific clearance of apoptotic cells Nature 405 2000 85 90
19. C. Hadnagy Letter: Coombs-positive haemolytic anaemia provoked by chlorpromazine Lancet 1 1976 423
20. H. Hagerstrand, T.H. Holmstrom, M. Bobrowska-Hagerstrand, J.E. Eriksson, and B. Isomaa Amphiphile-induced phosphatidylserine exposure in human erythrocytes Mol. Membr. Biol. 15 1998 89 95
21. P.M. Henson, D.L. Bratton, and V.A. Fadok The phosphatidylserine receptor: a crucial molecular switch? Nat. Rev. Mol. Cell Biol. 2 2001 627 633
22. S.M. Huber, N. Gamper, and F. Lang Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts Pflugers Arch. 441 2001 551 558
23. D.S. Kempe, P.A. Lang, K. Eisele, B.A. Klarl, T. Wieder, S.M. Huber, C. Duranton, and F. Lang Stimulation of erythrocyte phosphatidylserine exposure by lead ions Am. J. Physiol. Cell Physiol. 288 2005 C396 C402
24. D.J. King, and E. Wager Haematological safety of antipsychotic drugs J. Psychopharmacol. 12 1998 283 288
25. F. Lang, G.L. Busch, M. Ritter, H. Volkl, S. Waldegger, E. Gulbins, and D. Haussinger Functional significance of cell volume regulatory mechanisms Physiol. Rev. 78 1998 247 306
26. K.S. Lang, B. Roll, S. Myssina, M. Schittenhelm, H.G. Scheel-Walter, L. Kanz, J. Fritz, F. Lang, S.M. Huber, and T. Wieder Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency Cell Physiol. Biochem. 12 2002 365 372
27. K.S. Lang, C. Duranton, H. Poehlmann, S. Myssina, C. Bauer, F. Lang, T. Wieder, and S.M. Huber Cation channels trigger apoptotic death of erythorcytes Cell Death Differ. 10 2003 249 256
28. P.A. Lang, S. Kaiser, S. Myssina, T. Wieder, F. Lang, and S.M. Huber Role of Ca2+-activated K+ channels in human erythrocyte apoptosis Am. J. Physiol. Cell Physiol. 285 2003 C1553 C1560
29. K.S. Lang, S. Myssina, V. Brand, C. Sandu, P.A. Lang, S. Berchtold, S.M. Huber, F. Lang, and T. Wieder Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes Cell Death Differ. 11 2004 231 243
30. P.A. Lang, S. Kaiser, S. Myssina, C. Birka, C. Weinstock, H. Northoff, T. Wieder, F. Lang, and S.M. Huber Effect of Vibrio parahaemolyticus haemolysin on human erythrocytes Cell Microbiol. 6 2004 391 400
31. K.S. Lang, P.A. Lang, C. Bauer, C. Duranton, T. Wieder, S.M. Huber, and F. Lang Mechanisms of suicidal erythrocyte death Cell Physiol. Biochem. 15 2005 195 202
32. S. Myssina, P.A. Lang, D.S. Kempe, S. Kaiser, S.M. Huber, T. Wieder, and F. Lang Cl-channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis' Cell Physiol. Biochem. 14 2004 241 248
33. L. Rice, and C.P. Alfrey The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations Cell Physiol. Biochem. 15 2005 245 250
34. J. Rosso, A. Zachowski, and P.F. Devaux Influence of chlorpromazine on the transverse mobility of phospholipids in the human erythrocyte membrane: relation to shape changes Biochim. Biophys. Acta 942 1988 271 279
35. E. Schneider, C.W. Haest, G. Plasa, and B. Deuticke Bacterial cytotoxins, amphotericin B and local anesthetics enhance transbilayer mobility of phospholipids in erythrocyte membranes. Consequences for phospholipid asymmetry Biochim. Biophys. Acta 855 1986 325 336
36. S.L. Schrier, D.T. Chiu, M. Yee, K. Sizer, and B. Lubin Alteration of membrane phospholipid bilayer organization in human erythrocytes during drug-induced endocytosis J. Clin. Invest. 72 1983 1698 1705
37. S.L. Schrier, I. Junga, and L. Ma Studies on the effect of vanadate on endocytosis and shape changes in human red blood cells and ghosts Blood 68 1986 1008 1014
38. S.L. Schrier, A. Zachowski, and P.F. Devaux Mechanisms of amphipath-induced stomatocytosis in human erythrocytes Blood 79 1992 782 786
39. P.B. Stein, and M.J. Inwood Hemolytic anemia associated with chlorpromazine therapy Can. J. Psychiatry 25 1980 659 661
40. A.A. Thompson, A.S. Cornelius, T. Asakura, and K. Horiuchi Comparative studies of phenothiazine derivatives for their effects on swelling of normal and sickle erythrocytes Gen. Pharmacol. 24 1993 999 1006
41. M.B. Van der Weyden, M.F. Collecutt, A. Davidson, and B.S. Faragher Chlorpromazine-associated haemolysis in anorexia nervosa Acta Haematol. 73 1985 111 113
42. L.A. Woon, J.W. Holland, E.P. Kable, and B.D. Roufogalis Ca2+ sensitivity of phospholipid scrambling in human red cell ghosts Cell Calcium 25 1999 313 320