Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 575, Issue 1-2, 2005, Pages 47-60

  Frötschl, Roland ^a   Weickardt, Sandra ^a   Staszewski, Solveig ^a   Kaufmann, Gabriele ^a   Kasper, Peter ^a  

^a FEDERAL INSTITUTE FOR DRUGS AND MEDICAL DEVICES   (Germany)

Author keywords

Chlorpromazine; HepG2; Photogenotoxic; Time kinetics; Toxicogenomics

Indexed keywords

CHLORPROMAZINE;

CELL CYCLE; CELL FUNCTION; CELL PROLIFERATION; CELL STRAIN HEPG2; COMET ASSAY; CONFERENCE PAPER; DNA DAMAGE; DNA MICROARRAY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE MUTATION; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION; ULTRAVIOLET IRRADIATION; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CHLORPROMAZINE; COMET ASSAY; DNA DAMAGE; DNA FRAGMENTATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MUTAGENS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 19544383087     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.03.002     Document Type: Conference Paper

References (27)

1. S.A. Amundson, M. Bittner, Y. Chen, J. Trent, P. Meltzer, and A.J. Fornace Jr. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress response Oncogene 18 1999 3666 3672
2. D.A. Dickinson, G.R. Warnes, G. Quievryn, J. Messer, A. Zhitkovich, E. Rubitski, and J. Aubrecht Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis Mutat. Res. 549 2004 29 41
3. H. Ellinger-Ziegelbauer, B. Stuart, B. Wahle, W. Bomann, and H.J. Ahr Characteristic expression profiles induced by genotoxic carcinogens in rat liver Toxicol. Sci. 77 2004 19 34
4. T. Hu, D.P. Gibson, G.J. Carr, S.M. Torontali, J.P. Tiesman, J.G. Chaney, and M.J. Aardema Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins Mutat. Res. 549 2004 5 27
5. R.K. Newton, M.J. Aardema, and J. Aubrecht The utility of DNA microarrays for characterizing genotoxicity Environ. Health Perspect. 112 2004 420 422
6. J.H.M. van Delft, E. van Agen, S.G.J. van Breda, M.H. Herwijnen, Y.C.M. Staal, and J.C.S. Kleinjans Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling Carcinogenesis 25 2004 1265 1276
7. L. Müller, and P. Kasper Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: Experience with pharmaceuticals Mutat. Res. 464 2000 19 34
8. E. Gocke Photochemical mutagenesis: examples and toxicological relevance Mutat. Res. 366 1996 9 21
9. B. Kersten, P. Kasper, S.Y. Brendler-Schwaab, and L. Müller Use of the photo-micronucleus assay in Chinese hamster V79 cells to study photochemical genotoxicity Mutat. Res. 519 2002 49 66
10. A.A. Chetelat, S. Albertini, J.H. Dresp, R. Strobel, and E. Gocke Photomutagenesis test development I: 8-methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays Mutat. Res. 292 1993 241 250
11. A.A. Chetelat, J.H. Dresp, and E. Gocke Photomutagenesis test development II: 8-methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells Mutat. Res. 292 1993 251 258
12. A.J. Harris, S.L. Dial, and D.A. Casciano Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells Mutat. Res. 549 2004 79 99
13. N.P. Singh, M.T. McCoy, R.R. Tice, and E.L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 175 1988 184 191
14. D.A. Hosack, G. Dennis Jr., B.T. Sherman, H.C. Lane, and R.A. Lempicki Identifying biological themes within lists of genes with EASE Genome Biol. 4 2003 4
15. L.R. Bandara, E.W. Lam, T.S. Sorensen, M. Zamanian, R. Girling, and N.B. La Thangue DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein EMBO J. 13 1994 3104 3114
16. S. Sarraj, R. Farb, and R.E. Martell Reconstitution of DNA synthetic capacity in senescent normal human fibroblasts by expressing cellular factors E2F and Mdm2 Exp. Cell. Res. 270 2001 268 276
17. P. Singh, S.H. Wong, and W. Hong Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation EMBO J. 13 1994 3329 3338
18. E.A. Conner, E.R. Lemmer, M. Omori, P.J. Wirth, V.M. Factor, and S.S. Thorgeirsson Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis Oncogene 19 2000 5054 5062
19. S.Y. Zhang, S.C. Liu, D.G. Johnson, and A.J. Klein-Szanto E2F-1 gene transfer enhances invasiveness of human head and neck carcinoma cell lines Cancer Res. 60 2000 5972 5976
20. L. Yamasaki Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action Biochim. Biophys. Acta 423 1999 M9 M15
21. N. Pediconi, A. Ianari, A. Costanzo, L. Belloni, R. Gallo, L. Cimino, A. Porcellini, I. Screpanti, C. Balsano, E. Alesse, A. Gulino, and M. Levrero Differential regulation of E2F1 apoptotic target genes in response to DNA damage Nat. Cell Biol. 5 2003 552 558
22. R. Girling, J.F. Partridge, L.R. Bandara, N. Burden, N.F. Totty, J.J. Hsuan, and N.B. La Thangue A new component of the transcription factor DRTF1/E2F Nature 365 1993 468
23. C.A. Koch-Paiz, S.A. Amundson, M.L. Bittner, P.S. Meltzer, and A.J. Fornace Jr. Functional genomics of UV radiation responses in human cells Mutat. Res. 549 2004 65 78
24. G.S. Akerman, B.A. Rosenzweig, O.E. Domon, L.J. McGarrity, L.R. Blankenship, C.A. Tsai, S.J. Culp, J.T. MacGregor, F.D. Sistare, J.J. Chen, and S.M. Morris Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells Mutat. Res. 549 2004 43 64
25. Z. Hu, S. Jin, and K.W. Scotto Transcriptional activation of the MDR1 gene by UV irradiation J. Biol. Chem. 275 2000 2979 2985
26. S. Jean, C. Bideau, L. Bellon, G. Halimi, M.M. De, T. Orsiere, G. Dumenil, J.L. Berge-Lefranc, and A. Botta The expression of genes induced in melanocytes by exposure to 365 nm UVA: study by cDNA arrays and real-time quantitative RT-PCR Biochim. Biophys. Acta 1522 2001 89 96
27. T. Abe, N. Oue, W. Yasui, and M. Ryoji Rapid and preferential induction of ATF3 transcription in response to low doses of UVA light Biochem. Biophys. Res. Commun. 310 2003 1168 1174