Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays

Environmental Health Perspectives

Volumn 104, Issue 12, 1996, Pages 1296-1300

  Shelby, Michael D ^a   Newbold, Retha R ^a   Tully, Douglas B ^a   Chae, Kun ^a   Davis, Vicki L ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Competitive binding; Endocrine disruptors; Estrogen receptor; Transfection; Uterotropic assay

Indexed keywords

4 HYDROXYTAMOXIFEN; CHLORDECONE; CHLORPHENOTANE; DIETHYLSTILBESTROL; ENDOSULFAN; ENVIRONMENTAL CHEMICAL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; METHOXYCHLOR; PHENOL DERIVATIVE; TAMOXIFEN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC TRANSFECTION; HEALTH; HELA CELL; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SCREENING; TRANSCRIPTION INITIATION; WILDLIFE;

EID: 0030498123     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.961041296     Document Type: Article

References (24)

1. Hertz R. The estrogen problem - retrospect and prospect. In: Estrogens in the environment II (McLachlan JA, ed). New York:Elsevier, 1985;1-11.
2. McLachlan JA. Functional toxicology: a new approach to detect biologically active xenobiotics. Environ Health Perspect 101:386-387 (1993).
3. Colborn T, Dumanoski D, Myers JP. Our stolen future: are we threatening our fertility, intelligence, and survival? A scientific detective story. New York:Penguin Group, 1996.
4. Estrogens in the environment III: global health implications. Environ Health Perspect 103(suppl 7):3-178 (1995).
5. Gorski J, Welshons W, Sakai D. Remodeling the estrogen receptor model. Mol Cell Endocrinol 36:11-15 (1984).
6. Makela S. Davis VL, Tally WC, Korkman J, Salo L, Santti R, Vihko R, Korach KS. Dietary estrogens act through receptor mediated processes and show no antiestrogenicity in cultured breast cancer cells. Environ Health Perspect 102:572-578 (1994).
7. Isenhower WDJ, Newbold RR, Cefalo RC, Korach KS, McLachlan JA. Absence of estrogenic activity in some drugs commonly used during preganancy. Biol Res Pregnancy 7:6-10 (1986).
8. Korach KS. Estrogen action in mouse uterus: characterization of cytosol and nuclear receptor system. Endocrinology 104:1324-1332 (1979).
9. Migliaccio S, Davis VL, Gibson MK, Gray TK, Korach KS. Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transferred with estrogen receptor. Endocinology 130:2617-2624 (1992).
10. Jordan VC. Tamoxifen: toxicities and drug resistance during the treatment and prevention of breast cancer. Annu Rev Pharmacol Toxicol 35:194-211 (1995).
11. Harper MJ. Agents with antifertility effects during preimplantation stages of pregnancy. In: Biology of mammalian fertilization and implantation (Hafez ES, Moghissi KS, eds). Springfield, IL:Thomas & Co, 1972;431-492.
12. Bulger WH, Muccitelli RM, Kupfer D. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites: role of hepatic monoxygenase in methoxychlor activations. Biochem Pharmacol 28:2417-2423 (1978).
13. Bulger WH, Kupfer D. Estrogenic activity of pesticides and other xenobiotics on the uterus and male reproductive tract. In: Endocrine toxicology (Thomas JA, Korach KS, McLachlan JA, eds). New York:Raven Press, 1985;1-33.
14. Bitman J, Cecil HC, Harris SJ, Fries GF. Estrogenic activity of o,p'-DDT in the mammalian uterus and avian oviduct. Science 162:371-372 (1968).
15. Kupfer D, Bulger WH. Estrogenic properties of DDT and its analogs. In: Estrogens in the environment (McLachlan JA, ed). New York:Elsevier, 1980;239-263.
16. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ, McLachlan JA. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272:1489-1492 (1996).
17. Soto AM, Justicia H, Wray JW, Sonnenschein C. p-Nonylphenol: an estrogenic xenobiotic released from modified polystyrene. Environ Health Perspect 92:167-173 (1991).
18. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 185:175-182 (1994).
19. Lech JJ, Lewis SK, Ren L. In vivo estrogenic activity of nonylphenol in rainbow trout. Fundam Appl Toxicol 30:229-232 (1996).
20. Soto AM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 102:380-383 (1994).
21. McFarland LZ, Lacy PB. Physiologic and endocrinologic effects of the insecticide kepone on the Japanese quail. Toxicol Appl Pharmacol 15:441-450 (1969).
22. Palmiter RD, Mulvihill ER. Estrogenic activity of the insecticide kepone on the chicken oviduct. Science 162:371-372 (1968).
23. Kupfer D. Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit Rev Toxicol 4:83-124 (1975).
24. Eroschenko VP, Palmiter RRD. Estrogenicity of kepone in birds and mammals. In: Estrogens in the environment (McLachlan JA, ed). New York:Elsevier, 1980;305-323.