Serum cytokine levels in active uveitis and remission

Current Eye Research

Volumn 32, Issue 7-8, 2007, Pages 669-675

  Kramer, M ^a,b   Monselise, Y ^a   Bahar, I ^a,b   Cohen, Y ^c   Weinberger, D ^a,b   Goldenberg Cohen, N ^b,d  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

^d SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

Author keywords

Cytokines; IL 6; IL 8; TNF ; Uveitis

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

AGE DISTRIBUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IRIDOCYCLITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REMISSION; UVEITIS;

ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; PANUVEITIS; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS, ANTERIOR; UVEITIS, POSTERIOR;

EID: 34548626278     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701523147     Document Type: Article

References (29)

1. Standardization of uveitis nomenclature for reporting clinical data. results of the first international workshop. The standardization of uveitis nomenclature (SUN) working group. AM J Ophthalmol. 2005;140:509-516.
2. Bloch-Michel E, Nussenblatt RB. International Uveitis Study Group recommendations for evaluation of intraocular inflammatory disease. Am J Ophthalmol. 1987;103: 234-235.
3. Jha P, Sohn JH, Xu Q, Nishihori H, Wang Y, Nishihori S, Manickam B, Kaplan HJ, Bora PS, Bora NS. The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2006;47:1030-1038.
4. Holtkamp GM, Kijlstra A, Peek R, de Vos AF. Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retin Eye Res. 2001;20:29-48.
5. Takase H, Futagami Y, Yoshida T, Kamoi K, Sugita S, Imai Y, Mochizuki M. Cytokine profile in aqueous humor and sera of patients with infectious or non-infectious uveitis. Invest Ophthalmol Vis Sci. 2006;47:1557-1561.
6. Suhler EB, Smith JR, Wertheim MS, Lauer AK, Kurz DE, Pickard TD, Rosenbaum JT. A prospective trial of infliximab therapy for refractory uveitis: preliminary safety and efficacy outcomes. Arch Ophthalmol. 2005;123:903-912.
7. Santos Lacomba M, Marcos Martin C, Chamond RR, Gallardo Galera JM, Omar M, Estevez EC. Aqueous and serum interferon γ, interleukin (IL) 2, IL-4, and IL-10 in patients with uveitis. Arch Ophthalmol. 2000;118:768-772.
8. Ongkosuwito JV, Ferson EJ, Van Doornik CEM, Van der Lelij A, Hoyng CB, La Heij EC, Kijlstra A. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Invest Ophthalmol Vis Sci 1998;39:2659-2665.
9. Santos Lacomba M, Marcos Martin C, Gallardo Galeda JM, Gómez Vidal MA, Collantes Estévez E, Ramírez Chamond R, Omar MM.. Aqueous humor and serum tumor necrosis factor-α in clinical uveitis. Ophthalmic Res. 2001;33:251-255.
10. Klok AM, Luyendijk L, Zaal MJW, Rothova A, Hack CE, Kijlstra A. Elevated serum IL-8 levels are associated with disease activity in idiopathic intermediate uveitis. Br J Ophthalmol. 1998;82:871-874.
11. Gur-Toy G, Lenk N, Yalcin B, Aksaray S, Alli N. Serum interleukin-8 as a serologic marker of activity in Behcet's disease. Int J Dermatol. 2005;44:657-660.
12. Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest. 1998;101:311-320.
13. Santos Lacomba M, Marcos Martin C, Gallardo Galeda JM, Collantes Estévez E, Ramírez Chamond R, Omar MM, Gómez Vidal MA. Aqueous humor and serum interleukin-6 in clinical uveitis. Archivos de la Sociedad Espanola de Oftalmologia. 2001;76:345-350.
14. De Boer JH, Hack CE, Verhoeven AJ, Baarsma GS, de Jong PT, Rademakers AJ, de Vries-Knoppert WA, Rothova A, Kijlstra A. Chemo-attractant and neutrophil degranulation activities related to interleukin-8 in vitreous fluid in uveitis and vitreoretinal disorders. Invest Ophthalmol Vis Sci. 1993; 34:3376-3385.
15. Curnow SJ, Falciani F, Durrani OM, Cheung CMG, Ross EJ , Wloka K, Rauz S, Wallace GR, Salmon M, Murray PI . Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Invest Ophthalmol Vis Sci. 2005;46:4251-4259.
16. Evereklioglu C, Er H, Turkoz Y, Cekmen M. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease. Mediators Inflamm. 2002;11:87-93.
17. Bardak Y, Aridogan BC. The demonstration of serum interleukin 6-8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behcet's disease with ocular involvement. Ocul Immunol Inflamm. 2004;12:53-58.
18. Mo JS, Matsukawa A, Ohkawara S, Yoshinaga M. Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits. Exp Eye Res. 1999;68:333-340.
19. Sakaguchi M, Sugita S, Sagawa K, Itoh K, Mochizuki M. Cytokine production by T cells infiltrating in the eye of uveitis patients. Jpn J Ophthalmol. 1998;42:262-268.
20. de Vos AF, van Haren MA, Verhagen C, Hoekzema R, Kijlsrta A. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 1994;35:1100-1106.
21. Shen DF, Chang MA, Matteson DM, Buggage R, Kozhich AT, Chan CC. Biphasic ocular inflammatory response to endotoxin-induced uveitis in the mouse. Arch Ophthalmol. 2000; 18:521-527.
22. Murray PI, Hoekzema R, van Haren MA, de Hon FD, Kijlstra A. Aqueous humor interleukin-6 levels in uveitis. Invest Ophthalmol Vis Sci. 1990;31:917-920.
23. Lappin MR, Dow SW, Reif JS, Chavkin MJ. Elevated interleukin 6 activity in aqueous humor of cats with uveitis. Vet Immunol Immunopathol. 1997;58:17-26.
24. Ohta K, Wiggert B, Yamagami S, Taylor AW, Streilein JW. Analysis of immunomodulatory activities of aqueous humor from eyes of mice with experimental autoimmune uveitis. J Immunol. 2000;164:1185-1192.
25. Lee SJ, Li Z, Sherman B, Foster CS. Serum levels of tumor necrosis factor-alpha and interleukin-6 in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 1993;34:3522-3525.
26. Verma MJ, Mukaida N, Vollmer-Conna U, Matsushima K, Lloyd A, Wakefield D. Endotoxin-induced uveitis is partially inhibited by anti-IL-8 antibody treatment. Invest Ophthalmol Vis Sci. 1999;40:2465-2470.
27. Smith JR, Levinson RD, Holland GN, Jabs DA, Robinson MR, Whitcup SM, Rosenbaum JT. Differential efficacy of tumor necrosis factor inhibition in the management of inflammatory eye disease and associated rheumatic disease. Arthritis Rheum. 2001:45:252-257.
28. Demir T, Godekmerdan A, Balbaba M, Turkcuoglu P, Ilhan F, Demir N. The effect of infliximab, cyclosporine A and recombinant IL-10 on vitreous cytokine levels in experimental autoimmune uveitis. Indian J Ophthalmol. 2006;43:241-245.
29. Takase H, Yu CR, Liu X, Fujimoto C, Gery I, Egwuagu CE. Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins. J Neuroimmunol. 2005;168:118-127.