Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: Role of NF-κB, Akt, ROS and MAP kinase pathway

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 363-374

  Goel, Anita ^a   Prasad, Ashok K ^b   Parmar, Virinder S ^b   Ghosh, Balaram ^a   Saini, Neeru ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Apoptosis; Coumarin; Mitochondria; NF B; ROS

Indexed keywords

7,8 DIACETOXY 4 METHYLCOUMARIN; 7,8 DIACETOXY 4 METHYLTHIOCOUMARIN; CASPASE 3; CASPASE 9; COUMARIN DERIVATIVE; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOSIS INHIBITION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN FUNCTION; PROTEIN SECRETION;

ADENOCARCINOMA; APOPTOSIS; CASPASES; CELL PROLIFERATION; COUMARINS; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 62549109509     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.060     Document Type: Article

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