메뉴 건너뛰기




Volumn 203, Issue 2, 2009, Pages 303-315

Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: Role of 5-HT2A serotonergic and α1 adrenergic antagonism

Author keywords

Antipsychotic drugs; Aripiprazole; Chlorpromazine; Clozapine; Fluoxetine; Fluphenazine; Iloperidone; M100907; Melperone; N Desmethylclozapine; Norepinephrine; Olanzapine; Perphenazine; Prazosin; Pyrilamine; Quetiapine; Serotonin; Sertindole; Thioridazine; Zotepine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; AMPHETAMINE; ARIPIPRAZOLE; CHLORPROMAZINE; CLOZAPINE; DOPAMINE 2 RECEPTOR; FLUOXETINE; FLUPHENAZINE; HALOPERIDOL; HISTAMINE H1 RECEPTOR; ILOPERIDONE; MELPERONE; MEPYRAMINE; NORCLOZAPINE; OLANZAPINE; PERPHENAZINE; PRAZOSIN; QUETIAPINE; QUIPAZINE; RISPERIDONE; RITANSERIN; SCOPOLAMINE; SEROTONIN 2A RECEPTOR; SERTINDOLE; THIORIDAZINE; VOLINANSERIN; ZIPRASIDONE; ZOTEPINE;

EID: 62449283121     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1385-3     Document Type: Article
Times cited : (17)

References (67)
  • 1
    • 0032007608 scopus 로고    scopus 로고
    • Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence
    • J Arnt T Skarsfeldt 1998 Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence Neuropsychopharmacology 18 63 101
    • (1998) Neuropsychopharmacology , vol.18 , pp. 63-101
    • Arnt, J.1    Skarsfeldt, T.2
  • 2
    • 0030777698 scopus 로고    scopus 로고
    • Mutant mice and neuroscience: Recommendations concerning genetic background
    • Banbury Conference on Genetic Background in Mice
    • Banbury Conference on Genetic Background in Mice 1997 Mutant mice and neuroscience: recommendations concerning genetic background Neuron 19 755 759
    • (1997) Neuron , vol.19 , pp. 755-759
  • 5
    • 33644907147 scopus 로고    scopus 로고
    • Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase
    • LA Bruins Slot L De Vries A Newman-Tancredi D Cussac 2006 Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase Eur J Pharmacol 18 63 70
    • (2006) Eur J Pharmacol , vol.18 , pp. 63-70
    • Bruins Slot, L.A.1    De Vries, L.2    Newman-Tancredi, A.3    Cussac, D.4
  • 6
    • 0033303953 scopus 로고    scopus 로고
    • Interspecies variability and drug interactions of clozapine metabolism by microsomes
    • 5
    • H Bun B Disdier C Aubert J Catalin 1999 Interspecies variability and drug interactions of clozapine metabolism by microsomes Fundam Clin Pharmacol 13 5 577 81
    • (1999) Fundam Clin Pharmacol , vol.13 , pp. 577-81
    • Bun, H.1    Disdier, B.2    Aubert, C.3    Catalin, J.4
  • 8
    • 13244258371 scopus 로고    scopus 로고
    • 1A/B adrenoceptor subtype selectivity in the rat
    • 1A/B adrenoceptor subtype selectivity in the rat Eur Neuropsychopharmacol 15 231 234
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 231-234
    • Cahir, M.1    King, D.J.2
  • 9
    • 0030744574 scopus 로고    scopus 로고
    • Discriminative-stimulus effects of clozapine in squirrel monkeys: Comparison with conventional and novel antipsychotic drugs
    • GJ Carey J Bergman 1997 Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs Psychopharmacology (Berl) 132 261 269
    • (1997) Psychopharmacology (Berl) , vol.132 , pp. 261-269
    • Carey, G.J.1    Bergman, J.2
  • 10
    • 34247253866 scopus 로고    scopus 로고
    • Potentiation of olanzapine substitution in rats discriminating clozapine by the D2/3 agonist quinpirole
    • 3
    • JC Cole M Field HR Sumnall AJ Goudie 2007 Potentiation of olanzapine substitution in rats discriminating clozapine by the D2/3 agonist quinpirole Behav Pharmacol 18 3 185 190
    • (2007) Behav Pharmacol , vol.18 , pp. 185-190
    • Cole, J.C.1    Field, M.2    Sumnall, H.R.3    Goudie, A.J.4
  • 11
    • 0008473994 scopus 로고
    • Colpaert FC, Balster RL (eds) Springer, Berlin
    • Colpaert FC, Balster RL (eds). (1988) Transduction mechanisms of drug stimuli. Springer, Berlin
    • (1988) Transduction Mechanisms of Drug Stimuli
  • 12
    • 0037609789 scopus 로고    scopus 로고
    • Behavioral phenotyping of rodents
    • JN Crawley 2003 Behavioral phenotyping of rodents Comp Med 53 140 146
    • (2003) Comp Med , vol.53 , pp. 140-146
    • Crawley, J.N.1
  • 15
    • 0019432153 scopus 로고
    • Inter-animal olfactory cues in operant drug discrimination procedures in rats
    • 4
    • K Extance AJ Goudie 1981 Inter-animal olfactory cues in operant drug discrimination procedures in rats Psychopharmacology 73 4 363 371
    • (1981) Psychopharmacology , vol.73 , pp. 363-371
    • Extance, K.1    Goudie, A.J.2
  • 16
    • 0030729573 scopus 로고    scopus 로고
    • Further investigations of the interactions of antipsychotics with the (-)2,5-dimethoxy-4-methylamphetamine (DOM) discriminative stimulus
    • D Fiorella S Helsley RA Rabin JC Winter 1997 Further investigations of the interactions of antipsychotics with the (-)2,5-dimethoxy-4-methylamphetamine (DOM) discriminative stimulus Neuropharmacology 36 1463 1469
    • (1997) Neuropharmacology , vol.36 , pp. 1463-1469
    • Fiorella, D.1    Helsley, S.2    Rabin, R.A.3    Winter, J.C.4
  • 17
    • 0017798606 scopus 로고
    • Discriminative stimulus properties of clozapine and chlorpromazine
    • JA Goas JE Boston 1978 Discriminative stimulus properties of clozapine and chlorpromazine Pharmacol Biochem Behav 8 235 241
    • (1978) Pharmacol Biochem Behav , vol.8 , pp. 235-241
    • Goas, J.A.1    Boston, J.E.2
  • 18
    • 0032426485 scopus 로고    scopus 로고
    • Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: Tests with subtype selective receptor ligands
    • AJ Goudie JA Smith A Taylor MA Taylor MD Tricklebank 1998 Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands Behav Pharmacol 9 699 710
    • (1998) Behav Pharmacol , vol.9 , pp. 699-710
    • Goudie, A.J.1    Smith, J.A.2    Taylor, A.3    Taylor, M.A.4    Tricklebank, M.D.5
  • 19
    • 0031747077 scopus 로고    scopus 로고
    • Comparative characterisation of the discriminative stimulus properties of clozapine and other antipsychotics in rats
    • A Goudie A Taylor 1998 Comparative characterisation of the discriminative stimulus properties of clozapine and other antipsychotics in rats Psychopharmacology (Berl) 135 392 400
    • (1998) Psychopharmacology (Berl) , vol.135 , pp. 392-400
    • Goudie, A.1    Taylor, A.2
  • 20
    • 0346655094 scopus 로고    scopus 로고
    • Stimulus properties of the "atypical" antipsychotic zotepine in rats: Comparisons with clozapine and quetiapine
    • AJ Goudie JA Smith JC Cole 2004 Stimulus properties of the "atypical" antipsychotic zotepine in rats: comparisons with clozapine and quetiapine Pharmacol Biochem Behav 77 163 173
    • (2004) Pharmacol Biochem Behav , vol.77 , pp. 163-173
    • Goudie, A.J.1    Smith, J.A.2    Cole, J.C.3
  • 21
    • 0942277239 scopus 로고    scopus 로고
    • Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine
    • AJ Goudie JA Smith MJ Millan 2004 Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine Psychopharmacology (Berlin) 171 212 222
    • (2004) Psychopharmacology (Berlin) , vol.171 , pp. 212-222
    • Goudie, A.J.1    Smith, J.A.2    Millan, M.J.3
  • 22
    • 0022552977 scopus 로고
    • Phenothiazine drug metabolites: Dopamine D2 receptor, alpha 1- and alpha 2-adrenoceptor binding
    • PA Hals H Hall SG Dahl 1986 Phenothiazine drug metabolites: dopamine D2 receptor, alpha 1- and alpha 2-adrenoceptor binding Eur J Pharmacol 125 373 381
    • (1986) Eur J Pharmacol , vol.125 , pp. 373-381
    • Hals, P.A.1    Hall, H.2    Dahl, S.G.3
  • 23
    • 0026737420 scopus 로고
    • The discriminative stimulus effects of clozapine in pigeons: Involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors
    • EM Hoenicke SA Vanecek JH Woods 1992 The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors J Pharmacol Exp Ther 263 276 284
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 276-284
    • Hoenicke, E.M.1    Vanecek, S.A.2    Woods, J.H.3
  • 25
    • 0002427760 scopus 로고    scopus 로고
    • Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice
    • A Holmes CC Wrenn AP Harris KE Thayer JN Crawley 2002 Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice Genes Brain Behav 1 55 69
    • (2002) Genes Brain Behav , vol.1 , pp. 55-69
    • Holmes, A.1    Wrenn, C.C.2    Harris, A.P.3    Thayer, K.E.4    Crawley, J.N.5
  • 26
    • 0030430029 scopus 로고    scopus 로고
    • Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1- piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland
    • T Inoue M Domae K Yamada T Furukawa 1996 Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4- dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland J Pharmacol Exp Ther 277 137 143
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 137-143
    • Inoue, T.1    Domae, M.2    Yamada, K.3    Furukawa, T.4
  • 28
    • 0030765156 scopus 로고    scopus 로고
    • The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats
    • BM Kelley JH Porter 1997 The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats Pharmacol Biochem Behav 57 707 719
    • (1997) Pharmacol Biochem Behav , vol.57 , pp. 707-719
    • Kelley, B.M.1    Porter, J.H.2
  • 29
    • 0029023002 scopus 로고
    • 7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H) -quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity
    • T Kikuchi K Tottori Y Uwahodo T Hirose T Miwa Y Oshiro S Morita 1995 7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H) -quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity J Pharmacol Exp Ther 274 329 336
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 329-336
    • Kikuchi, T.1    Tottori, K.2    Uwahodo, Y.3    Hirose, T.4    Miwa, T.5    Oshiro, Y.6    Morita, S.7
  • 32
    • 0020004528 scopus 로고
    • [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role
    • JE Leysen CJ Niemegeers JM Van Nueten PM Laduron 1982 [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role Mol Pharmacol 21 294 300
    • (1982) Mol Pharmacol , vol.21 , pp. 294-300
    • Leysen, J.E.1    Niemegeers, C.J.2    Van Nueten, J.M.3    Laduron, P.M.4
  • 34
    • 2442547256 scopus 로고    scopus 로고
    • 1A receptor agonist LY293284 in the drug discrimination assay in rats
    • 1A receptor agonist LY293284 in the drug discrimination assay in rats Psychopharmacology 172 415 421
    • (2004) Psychopharmacology , vol.172 , pp. 415-421
    • Marona-Lewicka, D.1    Nichols, D.E.2
  • 35
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • HY Meltzer S Matsubara JC Lee 1989 Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values J Pharmacol Exp Ther 251 238 246
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 36
    • 0032161860 scopus 로고    scopus 로고
    • S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol
    • 3
    • MJ Millan A Gobert A Newman-Tancredi V Audinot F Lejeune JM Rivet D Cussac JP Nicolas O Muller G Lavielle 1998 S 16924 ((R)-2-[1-[2-(2,3-dihydro- benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol J Pharmacol Exp Ther 286 3 1341 1355
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1341-1355
    • Millan, M.J.1    Gobert, A.2    Newman-Tancredi, A.3    Audinot, V.4    Lejeune, F.5    Rivet, J.M.6    Cussac, D.7    Nicolas, J.P.8    Muller, O.9    Lavielle, G.10
  • 39
    • 0033970947 scopus 로고    scopus 로고
    • S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3- phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multiparametric comparison with haloperidol, clozapine, and 11 other antipsychotic agents
    • MJ Millan M Brocco JM Rivet V Audinot A Newman-Tancredi L Maiofiss S Queriaux N Despaux JL Peglion A Dekeyne 2000 S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multiparametric comparison with haloperidol, clozapine, and 11 other antipsychotic agents J Pharmacol Exp Ther 292 54 66
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 54-66
    • Millan, M.J.1    Brocco, M.2    Rivet, J.M.3    Audinot, V.4    Newman-Tancredi, A.5    Maiofiss, L.6    Queriaux, S.7    Despaux, N.8    Peglion, J.L.9    Dekeyne, A.10
  • 41
    • 0026757929 scopus 로고
    • The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent
    • NA Moore NC Tye MS Axton FC Risius 1992 The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent J Pharmacol Exp Ther 262 545 551
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 545-551
    • Moore, N.A.1    Tye, N.C.2    Axton, M.S.3    Risius, F.C.4
  • 43
    • 0023773451 scopus 로고
    • Cholinergic mediation of the discriminative stimulus properties of clozapine
    • EB Nielsen 1988 Cholinergic mediation of the discriminative stimulus properties of clozapine Psychopharmacology (Berl) 94 115 118
    • (1988) Psychopharmacology (Berl) , vol.94 , pp. 115-118
    • Nielsen, E.B.1
  • 44
    • 34547451141 scopus 로고    scopus 로고
    • Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D2L receptors are modified by co-transfection of D3 receptors: Potential role of heterodimer formation
    • F Novi MJ Millan GU Corsini R Maggio 2007 Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D2L receptors are modified by co-transfection of D3 receptors: potential role of heterodimer formation J Neurochem 102 1410 1424
    • (2007) J Neurochem , vol.102 , pp. 1410-1424
    • Novi, F.1    Millan, M.J.2    Corsini, G.U.3    Maggio, R.4
  • 45
    • 0002115642 scopus 로고    scopus 로고
    • Differential effects of fluoxetine and citalopram treatments on serotonin 5-HT2C receptor occupancy in rat brain
    • E-P Palvimaki M Kuoppamaki E Syvalahti J Hietala 1999 Differential effects of fluoxetine and citalopram treatments on serotonin 5-HT2C receptor occupancy in rat brain Int J Neuropsychopharmacol 2 95 99
    • (1999) Int J Neuropsychopharmacol , vol.2 , pp. 95-99
    • Palvimaki, E.-P.1    Kuoppamaki, M.2    Syvalahti, E.3    Hietala, J.4
  • 46
    • 18044399063 scopus 로고    scopus 로고
    • Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice
    • SD Philibin AJ Prus AL Pehrson JH Porter 2005 Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice Psychopharmacology (Berlin) 180 49 56
    • (2005) Psychopharmacology (Berlin) , vol.180 , pp. 49-56
    • Philibin, S.D.1    Prus, A.J.2    Pehrson, A.L.3    Porter, J.H.4
  • 47
    • 0034104464 scopus 로고    scopus 로고
    • Clozapine discrimination with a low training dose distinguishes atypical from typical antipsychotic drugs in rats
    • JH Porter SA Varvel RE Vann SD Philibin LE Wise 2000 Clozapine discrimination with a low training dose distinguishes atypical from typical antipsychotic drugs in rats Psychopharmacology (Berlin) 149 189 193
    • (2000) Psychopharmacology (Berlin) , vol.149 , pp. 189-193
    • Porter, J.H.1    Varvel, S.A.2    Vann, R.E.3    Philibin, S.D.4    Wise, L.E.5
  • 48
    • 14544291057 scopus 로고    scopus 로고
    • Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats
    • JH Porter AJ Prus RE Vann SA Varvel 2005 Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats Psychopharmacology (Berlin) 178 67 77
    • (2005) Psychopharmacology (Berlin) , vol.178 , pp. 67-77
    • Porter, J.H.1    Prus, A.J.2    Vann, R.E.3    Varvel, S.A.4
  • 49
    • 58149329140 scopus 로고    scopus 로고
    • A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice
    • JH Porter DM Walentiny SD Philibin SA Vunck JC Crabbe 2008 A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice Behav Pharmacol 19(5-6) 530 542
    • (2008) Behav Pharmacol , vol.1956 , pp. 530-542
    • Porter, J.H.1    Walentiny, D.M.2    Philibin, S.D.3    Vunck, S.A.4    Crabbe, J.C.5
  • 50
    • 1642493726 scopus 로고    scopus 로고
    • Discriminative stimulus properties of 1.25 mg/kg and 5.0 mg/kg doses of clozapine in rats: Examination of the role of dopamine, serotonin and muscarinic receptor mechanisms
    • AJ Prus LE Baker HY Meltzer 2004 Discriminative stimulus properties of 1.25 mg/kg and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin and muscarinic receptor mechanisms Pharmacol Biochem Behav 77 199 208
    • (2004) Pharmacol Biochem Behav , vol.77 , pp. 199-208
    • Prus, A.J.1    Baker, L.E.2    Meltzer, H.Y.3
  • 51
    • 18044376991 scopus 로고    scopus 로고
    • Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task
    • AJ Prus SD Philibin AL Pehrson CL Stephens RN Cooper LE Wise JH Porter 2005 Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task Drug Dev Res 64 55 65
    • (2005) Drug Dev Res , vol.64 , pp. 55-65
    • Prus, A.J.1    Philibin, S.D.2    Pehrson, A.L.3    Stephens, C.L.4    Cooper, R.N.5    Wise, L.E.6    Porter, J.H.7
  • 52
    • 26244462875 scopus 로고    scopus 로고
    • Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task
    • AJ Prus SD Philibin AL Pehrson JH Porter 2005 Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task Behav Pharmacol 16 511 520
    • (2005) Behav Pharmacol , vol.16 , pp. 511-520
    • Prus, A.J.1    Philibin, S.D.2    Pehrson, A.L.3    Porter, J.H.4
  • 53
    • 33644608161 scopus 로고    scopus 로고
    • Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle
    • AJ Prus SD Philibin AL Pehrson JH Porter 2006 Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle Behav Pharmacol 17 185 194
    • (2006) Behav Pharmacol , vol.17 , pp. 185-194
    • Prus, A.J.1    Philibin, S.D.2    Pehrson, A.L.3    Porter, J.H.4
  • 56
    • 0021177284 scopus 로고
    • Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro
    • E Richelson A Nelson 1984 Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro E J Pharmacol 103 197 204
    • (1984) E J Pharmacol , vol.103 , pp. 197-204
    • Richelson, E.1    Nelson, A.2
  • 57
    • 0034711425 scopus 로고    scopus 로고
    • Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds
    • E Richelson T Souder 2000 Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds Life Sci 68 29 39
    • (2000) Life Sci , vol.68 , pp. 29-39
    • Richelson, E.1    Souder, T.2
  • 65
    • 0026495282 scopus 로고
    • Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure
    • JL Wiley JH Porter 1992 Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure Pharmacol Biochem Behav 43 961 965
    • (1992) Pharmacol Biochem Behav , vol.43 , pp. 961-965
    • Wiley, J.L.1    Porter, J.H.2
  • 66
    • 0013656538 scopus 로고
    • Effects of serotonergic drugs in rats trained to discriminate clozapine from haloperidol
    • JL Wiley JH Porter 1993 Effects of serotonergic drugs in rats trained to discriminate clozapine from haloperidol Bull Psychon Soc 31 94 96
    • (1993) Bull Psychon Soc , vol.31 , pp. 94-96
    • Wiley, J.L.1    Porter, J.H.2
  • 67
    • 0033675163 scopus 로고    scopus 로고
    • Dissecting the behaviour of transgenic mice: Is it the mutation, the genetic background, or the environment?
    • DP Wolfer HP Lipp 2000 Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment? Exp Physiol 85 627 634
    • (2000) Exp Physiol , vol.85 , pp. 627-634
    • Wolfer, D.P.1    Lipp, H.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.