Discriminative-stimulus effects of clozapine in squirrel monkeys: Comparison with conventional and novel antipsychotic drugs

Psychopharmacology

Volumn 132, Issue 3, 1997, Pages 261-269

  Carey, Galen J ^a,b   Bergman, Jack ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c MCLEAN HOSPITAL   (United States)

Author keywords

(+) PHNO; Atypical antipsychotic; Chlorpromazine; Clozapine; Drug discrimination; Fluperlapine; Haloperidol; JL 18; JL 5; JL 8; Olanzapine; Perlapine; Remoxipride; Risperidone; Seroquel; Squirrel monkeys; Thioridazine

Indexed keywords

AMOXAPINE; CHLORPROMAZINE; CLOTIAPINE; CLOZAPINE; CLOZAPINE DERIVATIVE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; FLUPERLAPINE; HALOPERIDOL; JL 18; JL 5; JL 8; LOXAPINE; NAXAGOLIDE; NEUROLEPTIC AGENT; OLANZAPINE; PERLAPINE; PHENOTHIAZINE DERIVATIVE; QUETIAPINE; REMOXIPRIDE; RISPERIDONE; SERTINDOLE; THIORIDAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; INSTRUMENTAL CONDITIONING; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; SQUIRREL MONKEY; STIMULUS GENERALIZATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; CONDITIONING, OPERANT; DISCRIMINATION (PSYCHOLOGY); MALE; RECEPTORS, DOPAMINE D2; SAIMIRI; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030744574     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050344     Document Type: Article

References (52)

1. 2 receptor blocking agent. Curr Ther Res 40: 492-499
2. Browne RG, Koe BK (1982) Clozapine and agents with similar behavioral and biochemical properties. In: Colpaert FC, Slangen KF (eds) Drug discrimination: applications in CNS pharmacology. Elsevier, Amsterdam, pp 241-256
3. Bruhwyler J, Chleide E, Mercier M (1990) Clozapine: an atypical neuroleptic. Neurosci Behav Rev 14: 357-363
4. Bruhwyler J, Liégeois JF, Chleide E, Rogister F, Damas J, Delarge J, Mercier M (1992) Comparative study of typical neuroleptics, clozapine and newly synthesized clozapine analogues: correlations between neurochemistry and behavior. Behav Pharmacol 3: 567-579
5. Bymaster FP, Calligaro DO, Falcone JF, Marsh RD, Moore NA, Tye NC, Seeman P, Wong DT (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14[2]: 87-96
6. Canon JG (1979) A comparison of clozapine, chlorpromazine and thioridazine upon DRL performance in squirrel monkeys. Psychopharmacology 64: 55-60
7. Canon JG, Lippa AS (1977) Effects of clozapine, chlorpromazine and diazepam upon adjunctive and schedule controlled behavior. Pharmacol Biochem Behav 6: 581-587
8. Claas F (1989) Drug-induced agranulocytosis: review of possible mechanisms, and prospects for clozapine studies. Psychopharmacology 99: S113-S117
9. Colpaert FC, Niemeegeers CJE, Janssen PAJ (1976) Theoretical considerations on drug discrimination learning. Psychopharmacologia 46: 169-177
10. Coward DM (1992) General pharmacology of clozapine. Br J Psychiatry 160 [suppl 17]: 5-11
11. DeMaio D (1972) Clozapine, a novel major tranquillizer. Arzneimittelforschung 22: 919-921
12. 1c antagonist, and negative symptoms in schizophrenia: a placebo-controlled double-blind trial. Br J Psychiatry 163: 451-455
13. Ebadi M, Srinivasan SK (1995) Pathogenesis, prevention, and treatment of neuroleptic-induced movement disorders. Pharmacol Rev 47: 575-604
14. Eichenberger E (1984) Pharmacology of fluperlapine compared with clozapine. Drug Res 34: 110-113
15. Fitton A, Heel RC (1990) Clozapine, a review of its pharmacological properties and therapeutic use in schizophrenia. Drugs 40: 722-747
16. Fuller RW, Snoddy HD (1992) Neuroendocrine evidence for antagonism of serotonin and dopamine receptors by olanzapine, an antipsychotic drug candidate. Res Commun Chem Pathol Pharmacol 77: 87-93
17. Gauvin DV, Goulden KL, Holloway FA (1994) A three-choice haloperidol-saline-cocaine drug discrimination task in rats. Pharmacol Biochem Behav 49: 223-227
18. Gerlach J, Peacock L (1995) New antipsychotics: the present status. Int Clin Psychopharmacology 10 [suppl 3]: 39-48
19. Goas J, Boston JE (1978) Discriminative properties of clozapine and chlorpromazine. Pharmacol Biochem Behav 8: 235-241
20. Harris RT, Balster RL (1971) An analysis of the function of drugs in the stimulus control of operant behavior. In: Thompson T, Pickens R (eds) Stimulus properties of drugs. Appleton-Century-Crofts, New York, pp 111-132
21. 2 receptors. J Pharmacol Exp Ther 236: 176-284
22. Hippius H (1989) The history of clozapine. Psychopharmacology 99: S3-S5
23. 2 antagonistic properties. J Pharmacol Exp Ther 244: 685-693
24. 1-receptor antagonist SCH39166 in schizophrenia. Neuropsychopharmacology 10 [suppl 3]: 32S
25. Kinon BJ, Lieberman JA (1996) Mechanism of action of atypical antipsychotic drugs: a critical analysis. Psychopharmacology 124: 2-34
26. Krupp P, Barnes P (1992) Clozapine associated agranulocytosis: risk and aetiology. Br J Psychiatry 160 [suppl 17]: 38-41
27. Liégeois JF, Bruhwyler J, Damas J, Nguyen TP, Chleide E, Mercier M, Rogister F, Delarge J (1993) New pyridoben/odiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. J Med Chem 36: 2107-2214
28. 2 receptors. Psychopharmacology 112: S40-S54
29. Meltzer HY (1991) The mechanism of action of novel antipsychotic drugs. Schizophr Bull 17: 263-287
30. Meltzer HY, Nash JF (1991) Effects of drugs on serotonin receptors. Pharmacol Rev 43: 587-604
31. i values. J Pharmacol Exp Ther 251: 238-246
32. Migler BM, Warawa JE, Malik JB (1993) Seroquel: behavioral profile of a potential atypical antipsychotic. Psychopharmacology 112: 299-307
33. Moore NA, Tye NC, Risius FC, Pullar IA (1984) The discriminative properties of clozapine. Coll. Int. Neuropsychopharm. 14th Int. Congress, p 816
34. Moore NA, Tye NC, Axton SM, Risius FC (1992) The behavioral pharmacology of olanzapine, a novel atypical antipsychotic agent. J Pharmacol Exp Ther 262: 545-551
35. Moore NA, Calligaro DO, Wong DT, Bymaster F, Tye NC (1993) The pharmacology of olanzapine and other new antipsychotic agents. Curr Opin Invest Drugs 2: 281-293
36. Moore NA, Rees G, Sanger G, Tye, NC (1994) Effects of olanzapine and other antipsychotic agents on responding maintained by a conflict schedule. Behav Pharmacol 5: 196-202
37. Nielsen EB (1988) Cholinergic mediation of the discriminative-stimulus properties of clozapine. Psychopharmacology 94: 115-118
38. 1 receptor involvement in the discriminative-stimulus effects of SKF81297 in squirrel monkeys. J Pharmacol Exp Ther 267: 765-775
39. 4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. Psychopharmacology 120:365-368
40. Saller CF, Salama AI (1993) Seroquel: biochemical profile of a potential antipsychotic. Psychopharmacology 112: 285-292
41. Sanchez C, Arnt J, Dragsted N, Hytell J, Lemb¿l HL, Meier E, Perregaard J, Skarsfeldt T (1991) Neurochemical and in-vivo pharmacological profile of sertindole, a limbic selective neuroleptic compound. Drug Dev Res 22: 239-250
42. Sanger DJ (1986) Response decrement patterns after neuroleptic and non-neuroleptic drugs. Psychopharmacology 89: 98-104
43. Sanger DJ, Perrault G (1995) Effects of typical and atypical antipsychotic drugs on response decrement patterns in rats. J Pharmacol Exp Ther 272: 708-713
44. Spealman RD (1985) Effects of some dibenzo-azepines on suppressed and nonsuppressed behavior in squirrel monkeys. Psychopharmacology 85: 129-132
45. Spealman RD (1990) Antagonism of behavioral effects of cocaine by selective dopamine blockers. Psychopharmacology 101: 142-145
46. Spealman RD, Katz, J (1980) Some effects of clozapine on punished responding by mice and squirrel monkeys. J Pharmacol Exp Ther 212: 435-440
47. Spealman RD, Kelleher RT, Goldberg SR, DeWeese J, Goldberg DM (1982) Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys. J Pharmacol Exp Ther 224: 127-134
48. 2 receptors. J Pharmacol Exp Ther 266: 1374-1384
49. Wenger GR (1979) Effects of clozapine, chlorpromazine and haloperidol on schedule controlled behavior. Pharmacol Biochem Behav 11: 661-667
50. Wiley JL, Porter JH (1992) Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two lever drug discrimination procedure. Pharmacol Biochem Behav 43: 961-965
51. Wiley JL, Compton AD, Porter JH (1993) Effects of four antipsychotics on punished responding in rats. Pharmacol Biochem Behav 45: 263-267
52. Wiley JL, Compton AD, Porter JH (1994) Differential effects of clozapine and pimozide on fixed-ratio responding during repeated dosing. Pharmacol Biochem Behav 48: 253-257