Antipsychotics lack α1A/B adrenoceptor subtype selectivity in the rat

European Neuropsychopharmacology

Volumn 15, Issue 2, 2005, Pages 231-234

  Cahir, Marie ^a   King, David J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Antipsychotic; Radioligand binding; 1 adrenoceptor subtypes

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROMAZINE; CLOZAPINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PIMOZIDE; PRAZOSIN; QUETIAPINE; RECEPTOR SUBTYPE; RISPERIDONE; SERTINDOLE; SPIPERONE; THIORIDAZINE; TRIFLUOPERAZINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EXAMINATION; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SUBMANDIBULAR GLAND;

EID: 13244258371     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2004.10.002     Document Type: Article

References (19)

1. 1 noradrenergic antagonist J. Pharmacol. Exp. Ther. 283 1997 666 674
2. R.J. Baldessarini, D. Huston-Lyons, A. Campbell, E. Marsh, and M. Cohen Do central antiadrenergic actions contribute to the atypical properties of clozapine? Br. J. Psychiatry 160 S 17 1992 12 16
3. 1 adrenoceptor antagonists J. Med. Chem. 46 2003 265 283
4. F. Bymaster, D.O. Calligaro, J.F. Falcone, R.D. Marsh, N.A. Moore, N.C. Tye, P. Seeman, and D.T. Wong Radioreceptor binding profile of the atypical antipsychotic olanzapine Neuropsychopharmacology 14 1996 87 96
5. 1-adrenoceptor binding following chronic haloperidol and clozapine administration in the rat Psychopharmacology 172 2004 196 201
6. 1 adrenoceptors Eur. J. Pharmacol. 295 1996 69 73
7. 1-Adrenoceptor subtypes: a synopsis of their pharmacology and molecular biology Drug Dev. Res. 39 1996 54 107
8. 1A- adrenoceptors in rat mesenteric small arteries Eur. J. Pharmacol. 336 1997 29 35
9. J.E. Leysen, P.M.F. Janssen, L. Heylen, W. Gommeren, P.W. Gompel, A.S. Lesage, A. Megens, and A. Schotte Receptor interactions of new antipsychotics: relation to pharmacodynamic and clinical effects Int. J. Psychiatry Clin. Pract. 2 1998 S3 S17
10. 1A subtype in rat submaxillary gland Br. J. Pharmacol. 98 1989 883 889
11. 1A-adrenoceptor radioligand to rat and human tissues Eur. J. Pharmacol. 348 1998 287 295
12. S.J. Peroutka, and S.H. Snyder Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency Am. J. Psychiatry 137 1980 1518 1522
13. E. Richelson, and A. Nelson Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro Eur. J. Pharmacol. 103 1984 197 204
14. A. Schotte, P.F.M. Janssen, W. Gommeren, W.H.M.L Luyten, P. Van Gompel, A.S. Lesage, K. De Loore, and J.E. Leysen Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding Psychopharmacology 124 1996 57 73
15. 1B- adrenoceptors Eur. J. Pharmacol. 238 1993 407 410
16. N.R. Swerdlow, V. Bakshi, M. Waikar, and M. Geyer Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine treated rats Psychopharmacology 140 1998 75 80
17. 1B -adrenoceptor subtypes mediating noradrenalin-induced inositol phosphate formation in rat thalamus slices Eur. J. Pharmacol. 318 1996 175 184
18. 1-adrenergic receptor subtypes in rat brain J. Neurochem. 53 1989 1782 1786
19. M. Yang, F. Verfurth, R. Buscher, and M.C. Michel Is the alpha-1D adrenoceptor protein detectable in rat tissues? Naunyn-Schmiedeberg's Arch. Pharmacol. 355 1997 438 466