31P-MRS-Based Determination of Brain Intracellular and Interstitial pH: Its Application to in Vivo H+ Compartmentation and Cellular Regulation during Hypoxic/Ischemic Conditions

Neurochemical Research

Volumn 25, Issue 9-10, 2000, Pages 1385-1396

  Kintner, D B ^a   Anderson, M K ^b   Fitzpatrick Jr , J H ^b   Sailor, K A ^a   Gilboe, David D ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b 4630 MSC ^*

Author keywords

31P MRS; Extracellular pH; Hypoxia; Intracellular pH; Ischemia; pH regulation

Indexed keywords

PHOSPHORUS;

ANIMAL; BRAIN; BRAIN ISCHEMIA; DOG; HUMAN; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; RAT; REVIEW;

ANIMALS; BRAIN; DOGS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXIA-ISCHEMIA, BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS; RATS;

EID: 0034302832     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1007664700661     Document Type: Article

References (54)

1. Chesler, M. 1990. The regulation and modulation of pH in the nervous system. Prog. Neurobiol. 34:401-427.
2. Deitmer, J. W. and Rose, C. R. 1996. pH regulation and proton signalling by glial cells. Prog. Neurobiol. 48:73-103.
3. Roos, A. and Boron, W. F. 1981. Intracellular pH. Physiol. Rev. 61:296-434.
4. Chesler, M. 1986. Regulation of intracellular pH in reticulospinal neurones of the lamprey, Petromyzon marinus. J. Physiol. (Lond) 381:241-261.
5. Endres, W., Ballanyi, K., Serve, G., and Grafe, P. 1986. Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord. Neurosci. Lett. 72:54-58.
6. Heiple, J. M. and Taylor, D. L. 1981. An optical technique for measurement of intracellular pH in single living cells. Kroc. Found. Ser. 15:21-54.
7. Shrode, L. D. and Putnam, R. W. 1994. Intracellular pH regulation in primary rat astrocytes and C6 glioma cells. Glia 12:196-210.
8. Bevensee, M. O., Cummins, T. R., Haddad, G. G., Boron, W. F., and Boyarsky, G. 1996. pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats. J. Physiol. (Lond) 494:315-328.
9. Volk, C., Albert, T., and Kempski, O. S. 1998. A proton-translocating H+-ATPase is involved in C6 glial pH regulation. Biochim. Biophys. Acta 1372:28-36.
10. Hertz, L. and Peng, L. 1992. Energy metabolism at the cellular level of the CNS. Can. J. Physiol. Pharmacol. 70:8145-8157.
11. Kusumoto, M., Dux, E., Paschen, W., and Hossmann, K. A. 1996. Susceptibility of hippocampal and cortical neurons to Argon-mediated in vitro ischemia. J. Neurochem. 67:1613-1621.
12. Tombaugh, G. C. and Sapolsky, R. M. 1990. Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation. Brain Res. 506:343-345.
13. Goldberg, M. P. and Choi, D. W. 1900. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13:3510-3524.
14. Espanol, M. T., Litt, L., Chang, L.-H., James, T. L., Weinstein, P. R., and Chan, P. H. 1996. Adult rat brain-slice preparation for nuclear magnetic resonance spectroscopy studies of hypoxia. Anesthesiology 84:201-210.
15. Schurr, A. and Rigor, B. M. 1989. Cerebral ischemia revisited: New insights as revealed using in vitro brain slice preparations. Experientia 45:684-695.
16. Cowan, A. I. and Martin, R. L. 1995. Simultaneous measurement of pH and membrane potential in rat dorsal vagal motoneurons during normoxia and hypoxia: a comparison in bicarbonate and HEPES buffers. J. Neurophysiol. 74:2713-2721.
17. + exchange antiporter and control of intracellular pH in hippocampal brain slices. Brain Res. 731:108-113.
18. 1H nuclear magnetic resonance spectroscopy: role of extracellular bicarbonate and chloride. J. Neurochem. 62:656-664.
19. i peak. J. Neurochem. 71:2542-2548.
20. 2/H(+)-sensitive microelectrode based on a PVC-gelled membrane. Pflugers Arch. 423:193-201.
21. 2 tension in adult and neonatal brain slices under several experimental conditions. Brain Res. 568:159-164.
22. Whittingham, T. S., Lust, W. D., Christakis, D. A., and Passonneau, J. V. 1984. Metabolic stability of hippocampal slice preparations during prolonged incubation. J. Neurochem. 43: 689-696.
23. Roos, A. 1900. Intracellular pH and buffering power of rat brain. Am. J. Physiol. 221:176-181.
24. Messeter, K. and Siesjö, B. K. 1971. The intracellular pH′ in the brain in acute and sustained hypercapnia. Acta Physiol. Scand. 83:210-219.
25. LaManna, J. C. and McCracken, K. A. 1984. The use of neutral red as an intracellular pH indicator in rat brain cortex in vivo. Anal. Biochem. 142:117-125.
26. Ammann, D., Lanter, F., Steiner, R. A., Schulthess, P., Shijo, Y., and Simon, W. 1981. Neutral carrier based hydrogen ion selective microelectrode for extra- and intracellular studies. Anal. Chem. 53:2267-2269.
27. Chesler, M. and Kraig, R. P. 1989. Intracellular pH transients of mammalian astrocytes. J. Neurosci. 9:2011-2019.
28. +] in the hippocampus during recovery from short- term, transient ischemia. J. Cereb. Blood Flow Metab. 12:759-772.
29. 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays. Proc. Natl. Acad. Sci. U.S.A. 75:4925-4929.
30. Ackerman, J. J., Grove, T. H., Wong, G. G., Gadian, D. G., and Radda, G. K. surface coils. Nature 283:167-170.
31. Fukushima, E. and Stephen, B.W. 1981. Experimental pulse NMR: a nuts and bolts approach. Addison-Wesley Pub. Co., Reading, Mass.
32. Callaghan, P. T. 1991. Principles of nuclear magnetic resonance microscopy. Oxford University Press, New York.
33. 31P nuclear magnetic resonance spectroscopy. Neurology 35:781-788.
34. i- containing extracellular and cytoplasmic compartments in brain. J. Neurochem. 66:2612-2620.
35. Griffith, J. K., Cordisco, B. R., Lin, C. W., and LaManna, J. C. 1992. Distribution of intracellular pH in the rat brain cortex after global ischemia as measured by color film histophotometry of neutral red. Brain Res. 573:1-7.
36. 1H nuclear magnetic resonance study in the lamb. J. Neurochem. 49:75-82.
37. Nioka, S., Smith, D., Chance, B., and Lockard, S. 1990. Metabolic heterogeneity in brain tissue during incomplete ischemia and reperfusion. NMR Biomed. 3:239-247.
38. 31P NMR. Acta Physiol. Scand 136(Suppl. 582):73.
39. Robbins, R. C., Balaban, R. S., and Swain, J. A. 1990. Intermittent hypothermie asanguineous cerebral perfusion (cerebroplegia) protects the brain during prolonged circulatory arrest. A phosphorus 31 nuclear magnetic resonance study. J. Thorac. Cardiovasc. Surg. 99:878-884.
40. Portman, M. A. and Ning, X. H. 1990. Developmental adaptations in cytosolic phosphate content and pH regulation in the sheep heart in vivo. J. Clin. Invest. 86:1823-1828.
41. 31P NMR spectroscopy. Brain Res. 641:328-332.
42. 31P spectroscopy study of treated and untreated recovery of rat partial brain ischemia. Magn. Reson. Med. 34:542-547.
43. 31P-NMR. J. Neurochem. 72:405-412.
44. Kraig, R. P. and Chesler, M. 1990. Astrocytic acidosis in hy-perglycemic and complete ischemia. J. Cereb. Blood Flow Metab. 10:104-114.
45. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897-916.
46. BeltrandelRio, H. and Wilson, J. E. 1991. Hexokinase of rat brain mitochondria: relative importance of adenylate kinase and oxidative phosphorylation as sources of substrate ATP, and interaction with intramitochondrial compartments of ATP and ADP. Arch. Biochem. Biophys. 286:183-194.
47. Pulsinelli, W. A. and Cooper, A. J. 1989. Metabolic encephalopaties and coma, Pages 765-781, in Siegel, G., Agranoff, B., Ablers, R. W., and Molinoff, P. (eds.), Basic Neurochemistry. Raven Press, New York.
48. Berl, S. 1971. Cerebral amino acid metabolism in hepatic coma. Exp. Biol. Med. 4:71-84.
49. Gilboe, D. D., Kintner, D. B., Sailor, K. A., Anderson, M. E., and Fitzpatrick, J. H., Jr. 1998. Brain intracellular and interstitial pH changes during graded hypoxia, Pages 53-60, in Krieglstein, J. (ed.), Pharmacology of Cerebral Ischemia - 1998. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart,
50. Gottfried, J. A. and Chesler, M. 1996. Temporal resolution of activity-dependent pH shifts in rat hippocampal slices. J. Neurophysiol. 76:2804-2807.
51. Grieb, P. 1990. Effect of acetazolamide on brain intracellular pH. J. Cereb. Blood Flow Metab. 10:588-589.
52. Li, P. A. and Siesjö, B. K. 1997. Role of hyperglycaemia-related acidosis in ischaemic brain damage. Acta Physiol. Scand. 161: 567-580.
53. Choi, D. W. and Koh, J. Y. 1998. Zinc and brain injury. [Review]. Annu. Rev. Neurosci. 21:347-375.
54. Tombaugh, G. C. 1994. Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices. J. Neurosci. 14:5635-5643.