Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: Case-control studies and analyses of quantitative traits

BMC Medical Genetics

Volumn 9, Issue , 2008, Pages

  Andreasen, Camilla Helen ^a,b   Mogensen, Mette Sloth ^a   Borch Johnsen, Knut ^a,c,d   Sandbæk, Annelli ^d   Lauritzen, Torsten ^d   Almind, Katrine ^b   Hansen, Lars ^e   Jørgensen, Torben ^c,f   Pedersen, Oluf ^a,d,f   Hansen, Torben ^a,g  

^a STENO DIABETES CENTER   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e BRISTOL MYERS SQUIBB   (United States)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE ADAPTOR PROTEIN; PKLR PROTEIN; PYRUVATE KINASE; UNCLASSIFIED DRUG; NOS1AP PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; DENMARK; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; POPULATION BASED CASE CONTROL STUDY; QUANTITATIVE TRAIT; ALLELE; CASE CONTROL STUDY; ENZYMOLOGY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; LIVER; METABOLISM; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM;

STENO;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; ALLELES; CASE-CONTROL STUDIES; DENMARK; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LIVER; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRUVATE KINASE; QUANTITATIVE TRAIT, HERITABLE;

EID: 62349099727     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-9-118     Document Type: Article

References (38)

1. Das SK Elbein SC The search for type 2 diabetes susceptibility loci: The chromosome 1q story Curr Diab Rep 2007, 7:154-164. 10.1007/ s11892-007-0025-3 17425920
2. Das SK Hasstedt SJ Zhang Z Elbein SC Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians Diabetes 2004, 53:492-499. 10.2337/diabetes.53.2.492 14747303
3. Elbein SC Hoffman MD Teng K Leppert MF Hasstedt SJ A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians Diabetes 1999, 48:1175-1182. 10.2337/diabetes.48.5.1175 10331426
4. Hanson RL Ehm MG Pettitt DJ Prochazka M Thompson DB Timberlake D et al An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians Am J Hum Genet 1998, 63:1130-1138. 1377493 9758619 10.1086/302061
5. Hanson RL Imperatore G Narayan KM Roumain J Fagot-Campagna A Pettitt DJ et al Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians Diabetes Metab Res Rev 2001, 17:296-303. 10.1002/dmrr.213 11544614
6. Hsueh WC St Jean PL Mitchell BD Pollin TI Knowler WC Ehm MG et al Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: Evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24 Diabetes 2003, 52:550-557. 10.2337/diabetes.52.2.550 12540634
7. Langefeld CD Wagenknecht LE Rotter JI Williams AH Hokanson JE Saad MF et al Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study Diabetes 2004, 53:1170-1174. 10.2337/diabetes.53.4.1170 15047638
8. Meigs JB Panhuysen CI Myers RH Wilson PW Cupples LA A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study Diabetes 2002, 51:833-840. 10.2337/diabetes.51.3.833 11872688
9. Ng MC So WY Cox NJ Lam VK Cockram CS Critchley JA et al Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25 Diabetes 2004, 53:1609-1613. 10.2337/diabetes.53.6.1609 15161769
10. Ng MC So WY Lam VK Cockram CS Bell GI Cox NJ et al Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25 Diabetes 2004, 53:2676-2683. 10.2337/diabetes.53.10.2676 15448100
11. Vionnet N Hani EH Dupont S Gallina S Francke S Dotte S et al Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24 Am J Hum Genet 2000, 67:1470-1480. 1287924 11067779 10.1086/316887
12. Wiltshire S Hattersley AT Hitman GA Walker M Levy JC Sampson M et al A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q Am J Hum Genet 2001, 69:553-569. 1235485 11484155 10.1086/ 323249
13. Xiang K Wang Y Zheng T Jia W Li J Chen L et al Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: Significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24 Diabetes 2004, 53:228-234. 10.2337/diabetes.53.1.228 14693720
14. Zhao JY Xiong MM Huang W Wang H Zuo J Wu GD et al An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese J Mol Med 2005, 83:209-215. 10.1007/s00109-004-0587-3 15776287
15. Noguchi T Yamada K Yamagata K Takenaka M Nakajima H Imai E et al Expression of liver type pyruvate kinase in insulinoma cells: involvement of LF-B1 (HNF1) Biochem Biophys Res Commun 1991, 181:259-264. 10.1016/S0006-291X(05)81411-1 1720308
16. Yamada K Tanaka T Noguchi T Characterization and purification of carbohydrate response element-binding protein of the rat L-type pyruvate kinase gene promoter Biochem Biophys Res Commun 1999, 257:44-49. 10.1006/ bbrc.1999.0410 10092507
17. Wang H Antinozzi PA Hagenfeldt KA Maechler P Wollheim CB Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction EMBO J 2000, 19:4257-4264. 302029 10944108 10.1093/ emboj/19.16.4257
18. Shih DQ Screenan S Munoz KN Philipson L Pontoglio M Yaniv M et al Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism Diabetes 2001, 50:2472-2480. 10.2337/diabetes.50.11.2472 11679424
19. Jaffrey SR Snowman AM Eliasson MJ Cohen NA Snyder SH CAPON: A protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95 Neuron 1998, 20:115-124. 10.1016/ S0896-6273(00)80439-0 9459447
20. Wang H Chu W Das SK Ren Q Hasstedt SJ Elbein SC Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians Diabetes 2002, 51:2861-2865. 10.2337/diabetes.51.9.2861 12196482
21. Hasstedt SJ Chu WS Das SK Wang H Elbein SC Type 2 diabetes susceptibility genes on chromosome 1q21-24 Ann Hum Genet 2008, 72:163-169. 10.1111/j.1469-1809.2007.00416.x 18269685
22. Jorgensen T Borch-Johnsen K Thomsen TF Ibsen H Glumer C Pisinger C A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: Baseline results Inter99 Eur J Cardiovasc Prev Rehabil 2003, 10:377-386. 10.1097/01.hjr.0000096541.30533.82 14663300
23. Lauritzen T Griffin S Borch-Johnsen K Wareham NJ Wolffenbuttel BH Rutten G The ADDITION study: Proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening Int J Obes Relat Metab Disord 2000, 24(Suppl 3):S6-11. 11063279
24. World Health Organization Study Group Part 1: Diagnosis and Classification of Diabetes Mellitus Tech. Rep. Ser., no. WHO/NCD/NCS/ 99.2 World Health Organization, Geneva 1999.
25. Glumer C Jorgensen T Borch-Johnsen K Prevalences of diabetes and impaired glucose regulation in a Danish population: The Inter99 study Diabetes Care 2003, 26:2335-2340. 10.2337/diacare.26.8.2335 12882858
26. Hansen T Drivsholm T Urhammer SA Palacios RT Volund A Borch-Johnsen K et al The BIGTT test: A novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance Diabetes Care 2007, 30:257-262. 10.2337/dc06-1240 17259491
27. Benyamin B Sorensen TI Schousboe K Fenger M Visscher PM Kyvik KO Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia 2007, 50:1880-1888. 10.1007/s00125-007-0758-1 17624514
28. R Development Core Team R: A language and environment for statistical computing, R Foundation for Statistical Computering, Vienna, Australia 2008. http://www.R-project.org
29. Saxena R Voight BF Lyssenko V Burtt NP de Bakker PI Chen H et al Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 2007, 316:1331-1336. 10.1126/science.1142358 17463246
30. The Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007, 447:661-678. 10.1038/nature05911 17554300
31. Sladek R Rocheleau G Rung J Dina C Shen L Serre D et al A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 2007, 445:881-885. 10.1038/nature05616 17293876
32. Steinthorsdottir V Thorleifsson G Reynisdottir I Benediktsson R Jonsdottir T Walters GB et al A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Genet 2007, 39:770-775. 10.1038/ ng2043 17460697
33. Scott LJ Mohlke KL Bonnycastle LL Willer CJ Li Y Duren WL et al A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 2007, 316:1341-1345. 10.1126/ science.1142382 17463248
34. Zeggini E Weedon MN Lindgren CM Frayling TM Elliott KS Lango H et al Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 2007, 316:1336-1341. 10.1126/ science.1142364 17463249
35. Grarup N Rose CS Andersson EA Andersen G Nielsen AL Albrechtsen A Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: Validation and extension of genome-wide association studies Diabetes 2007, 56:3105-3111. 10.2337/db07-0856 17827400
36. Sparso T Andersen G Nielsen T Burgdorf KS Gjesing AP Nielsen AL et al The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes Diabetologia 2008, 51:70-75. 10.1007/ s00125-007-0865-z 18008060
37. Andreasen CH Stender-Petersen KL Mogensen MS Torekov SS Wegner L Andersen G Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation Diabetes 2008, 57:95-101. 10.2337/db07-0910 17942823
38. Prokopenko I Zeggini E Rayner NW Groves CJ Hanson RL Mitchell BD et al High-density association mapping and coprehensive tagging of the type 2 diabetes linkage region on chromosome 1q in 4 European populations EASD 2007 Abstract no. 0169. http://www.easd.org/easdwebfiles/annualmeeting/ 43rdmeeting/abstracts/documents/0169.doc