Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians

Diabetes/Metabolism Research and Reviews

Volumn 17, Issue 4, 2001, Pages 296-303

  Hanson, Robert L ^a   Imperatore, Giuseppina ^a   Narayan, K M Venkat ^a   Roumain, Janine ^a   Fagot Campagna, Anne ^a   Pettitt, David J ^a   Bennett, Peter H ^a   Knowler, William C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Diabetes; Genetics; Inheritance; Insulin secretion; Insulin sensitivity; Linkage; Type 2

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; CHROMOSOME 1Q; CHROMOSOME 9P; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; FAMILY STUDY; FEMALE; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HEREDITY; HERITABILITY; HUMAN; HUMAN TISSUE; INDIAN; INSULIN RELEASE; INSULIN SENSITIVITY; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SIBLING; VARIANCE;

ARIZONA; BODY MASS INDEX; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 9; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE TOLERANCE TEST; HUMANS; INDIANS, NORTH AMERICAN; INSULIN; INSULIN RESISTANCE; LOD SCORE; LONGITUDINAL STUDIES; MALE;

EID: 0034839379     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.213     Document Type: Article

References (53)

1. Insulin action, diabetogenes and the cause of type II diabetes
2. Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM)
3. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus
4. Pima Indians as a model to study the genetics of NIDDM
5. Genetic analysis of NIDDM: The study of quantitative traits
6. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies
7. Diabetes mellitus in American (Pima) Indians
8. Diabetes incidence and prevalence in Pima Indians: A 19-fold greater incidence than in Rochester, Minnesota
9. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
10. Diabetes Mellitus: Report of a WHO Study Group
11. Coated charcoal immunoassay of insulin
12. Glucose tolerance and insulin release, a mathematical approach: I. Assay of the beta-cell response after oral glucose loading
13. Glucose tolerance and insulin release, a mathematical approach: II. Approximation of the peripheral insulin resistance after oral glucose loading
14. Homoeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
15. Extensions to pedigree analysis III: Variance components by the scoring method
16. The MIXED procedure
17. Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder
18. Longitudinal data analysis for discrete and continuous outcomes
19. Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques
20. Robust variance-components approach for assessing genetic linkage in pedigrees
21. Exact multipoint quantitative-trait linkage analyses in pedigrees by variance components
22. Parametric and nonparametric linkage analysis: A unified multipoint approach
23. Construction of multilocus genetic linkage maps in humans
24. On the LOD score method in linkage analysis
25. Allele-sharing models: LOD scores and accurate linkage tests
26. Mapping genes in diabetes: Genetic epidemiological perspective
27. Approaches to studying the genetics of type 2 diabetes
28. Segregation analysis of non-insulin-dependent diabetes mellitus in Pima Indians: Evidence for a major-gene effect
29. An autosomal genomic scan for loci linked to pre-diabetic phenotypes in Pima Indians
30. Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians
31. Diminished serum insulin response to glucose in genetic prediabetic males with normal glucose tolerance
32. Levels of plasma insulin during cortisone glucose tolerance tests in "nondiabetic" relatives of diabetic patients
33. Glucose tolerance and insulin response in parents of patients with insulin-dependent and juvenile-onset non-insulin-dependent diabetes mellitus
34. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
35. Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes
36. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
37. Hyperinsulinemia in offspring of non-insulin-dependent diabetes mellitus patients: The role played by abnormal clearance of insulin
38. Metabolic abnormalities in children of non-insulin-dependent diabetics
39. Increased insulin concentrations in nondiabetic offspring of diabetic parents
40. Slow glucose removal and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
41. Glucose and insulin responses to intravenous glucose challenge in relatives of Nigerian patients with non-insulin-dependent diabetes mellitus
42. Insulin and glucose levels and prevalence of glucose intolerance in pedigrees with multiple diabetic siblings
43. Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
44. Multiple metabolic abnormalities in normal glucose tolerant relatives of NIDDM families
45. Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited: Metabolic studies on offspring of diabetic probands
46. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
47. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
48. Type 2 diabetes loci in the Old Order Amish
49. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
50. The British Diabetic Association Warren type 2 diabetes sibpair repository: Interim report on a genome-wide scan for linkage in 439 European sibpair families
51. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2 chromosome 1q21-q24
52. Confirmation of linkage results in affected sib-pair linkage analysis for complex genetic traits
53. Replication of linkage studies of complex traits: An examination of variation in location estimates