GPR3 receptor, a novel actor in the emotional-like responses

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Valverde, Olga ^a   Célérier, Evelyne ^a   Baranyi, Mária ^b   Vanderhaeghen, Pierre ^c   Maldonado, Rafael ^a   Sperlagh, Beata ^b   Vassart, Gilbert ^c   Ledent, Catherine ^c  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 3; MONOAMINE; UNCLASSIFIED DRUG; BIOGENIC AMINE; DRUG DERIVATIVE; GPR3 PROTEIN, MOUSE; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN REGION; CONTROLLED STUDY; COPING BEHAVIOR; CORTICOSTERONE RELEASE; EMOTION; EMOTIONAL DISORDER; EMOTIONAL STRESS; FEMALE; FRONTAL CORTEX; GENE DELETION; GENE FUNCTION; GENE LOCATION; HIPPOCAMPUS; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MOUSE; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; STRESS MANAGEMENT; TISSUE DISTRIBUTION; WILD TYPE; ADAPTIVE BEHAVIOR; ANIMAL; BRAIN; CELL MEMBRANE; CHO CELL; CRICETULUS; FLOW CYTOMETRY; GENETICS; HAMSTER; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

MUS;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; BRAIN; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; EMOTIONS; FLOW CYTOMETRY; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; SPHINGOSINE;

EID: 62249137701     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004704     Document Type: Article

References (53)

1. Malberg JE, Blendy JA (2005) Antidepressant action: to the nucleus and beyond. Trends Pharmacol Sci 26: 631-638.
2. Blendy JA (2006) The role of CREB in depression and antidepressant treatment. Biol Psychiatry 59: 1144-1150.
3. Carlezon WA Jr, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends Neurosci 28: 436-445.
4. Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, et al. (2004) Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology 29: 1122-1133.
5. Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, et al. (2002) Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology 27: 587-595.
6. Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, et al. (1995) Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem J 309(Pt 3): 837-843.
7. Ledent C, Demeestere I, Blum D, Petermans J, Hamalainen T, et al. (2005) Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci U S A 102: 8922-8926.
8. Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, et al. (2004) The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306: 1947-1950.
9. Vaccari S, Horner K, Mehlmann LM, Conti M (2008) Generation of mouse oocytes defective in cAMP synthesis and degradation: Endogenous cyclic AMP is essential for meiotic arrest. Dev Biol.
10. Hinckley M, Vaccari S, Horner K, Chen R, Conti M (2005) The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Dev Biol 287: 249-261.
11. Uhlenbrock K, Gassenhuber H, Kostenis E (2002) Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal 14: 941-953.
12. Lecourtier L, Kelly PH (2007) A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition. Neurosci Biobehav Rev 31: 658-672.
13. Sutherland RJ (1982) The dorsal diencephalic conduction system: a review of the anatomy and functions of the habenular complex. Neurosci Biobehav Rev 6: 1-13.
14. Morilak DA, Frazer A (2004) Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders. Int J Neuropsychopharmacol 7: 193-218.
15. Ressler KJ, Nemeroff CB (2000) Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12 Suppl 1: 2-19.
16. Vanderhaeghen P, Lu Q, Prakash N, Frisen J, Walsh CA, et al. (2000) A mapping label required for normal scale of body representation in the cortex. Nat Neurosci 3: 358-365.
17. Konig M, Zimmer AM, Steiner H, Holmes PV, Crawley JN, et al. (1996) Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 383: 535-538.
18. Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, et al. (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25: 195-200.
19. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85: 367-370.
20. Sansone M (1975) Benzodiazepines and amphetamine on avoidance behaviour in mice. Arch Int Pharmacodyn Ther 218: 125-132.
21. Bagdy G, Makara GB (1995) Paraventricular nucleus controls 5-HT2C receptor-mediated corticosterone and prolactin but not oxytocin and penile erection responses. Eur J Pharmacol 275: 301-305.
22. Baranyi M, Milusheva E, Vizi ES, Sperlagh B (2006) Chromatographic analysis of dopamine metabolism in a Parkinsonian model. J Chromatogr A 1120: 13-20.
23. Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S (2002) Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Mol Endocrinol 16: 736-746.
24. Adamus G, Arendt A, Hargrave PA (1991) Genetic control of antibody response to bovine rhodopsin in mice: epitope mapping of rhodopsin structure. J Neuroimmunol 34: 89-97.
25. Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, et al. (1993) Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett 336: 317-322.
26. Cryan JF, Mombereau C, Vassout A (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29: 571-625.
27. Porsolt RD (2000) Animal models of depression: utility for transgenic research. Rev Neurosci 11: 53-58.
28. Davidson RJ, Putnam KM, Larson CL (2000) Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence. Science 289: 591-594.
29. Contet C, Gaveriaux-Ruff C, Matifas A, Caradec C, Champy MF, et al. (2006) Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice. Neuropsychopharmacology 31: 1733-1744.
30. Robertson DA, Beattie JE, Reid IC, Balfour DJ (2005) Regulation of corticosteroid receptors in the rat brain: the role of serotonin and stress. Eur J Neurosci 21: 1511-1520.
31. Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, et al. (2004) Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci U S A 101: 11851-11856.
32. Wilson MA, Burghardt PR, Ford KA, Wilkinson MB, Primeaux SD (2004) Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females. Pharmacol Biochem Behav 78: 445-458.
33. Chamberlain B, Ervin FR, Pihl RO, Young SN (1987) The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacol Biochem Behav 28: 503-510.
34. Hen R (1996) Mean genes. Neuron 16: 17-21.
35. Pucilowski O, Kostowski W (1983) Aggressive behaviour and the central serotonergic systems. Behav Brain Res 9: 33-48.
36. Ferraro G, Montalbano ME, Sardo P, La GV (1997) Lateral habenula and hippocampus: a complex interaction raphe cells-mediated. J Neural Transm 104: 615-631.
37. Wang RY, Aghajanian GK (1977) Physiological evidence for habenula as major link between forebrain and midbrain raphe. Science 197: 89-91.
38. Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, et al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A 98: 2786-2791.
39. Ross SA, Wong JY, Clifford JJ, Kinsella A, Massalas JS, et al. (2000) Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J Neurosci 20: 6431-6441.
40. Salas R, Pieri F, Fung B, Dani JA, De Biasi M (2003) Altered anxiety-related responses in mutant mice lacking the beta4 subunit of the nicotinic receptor. J Neurosci 23: 6255-6263.
41. Caldecott-Hazard S, Mazziotta J, Phelps M (1988) Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography. J Neurosci 8: 1951-1961.
42. Shumake J, Edwards E, Gonzalez-Lima F (2003) Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior. Brain Res 963: 274-281.
43. Bjork JM, Dougherty DM, Moeller FG, Cherek DR, Swann AC (1999) The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control. Psychopharmacology (Berl) 142: 24-30.
44. Morris JS, Smith KA, Cowen PJ, Friston KJ, Dolan RJ (1999) Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. Neuroimage 10: 163-172.
45. Cherry JA, Davis RL (1999) Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J Comp Neurol 407: 287-301.
46. Civelli O (2005) GPCR deorphanizations: the novel, the known and the unexpected transmitters. Trends Pharmacol Sci 26: 15-19.
47. Joost P, Methner A (2002) Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol 3: RESEARCH0063.
48. Freudzon L, Norris RP, Hand AR, Tanaka S, Saeki Y, et al. (2005) Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J Cell Biol 171: 255-265.
49. Costa T, Cotecchia S (2005) Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors. Trends Pharmacol Sci 26: 618-624.
50. Nijenhuis WA, Oosterom J, Adan RA (2001) AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol 15: 164-171.
51. Deng J, Lang S, Wylie C, Hammes R (2008) The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes. J Biol Chem 193: 265-275.
52. Leurs R, Smit MJ, Alewijnse AE, Timmerman H (1998) Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends Biochem Sci 23: 418-422.
53. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.