Human cytochrome P450 1A2 involvement in the formation of reactive metabolites from a species-specific hepatotoxic pyrazolopyrimidine derivative, 5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine

Chemical Research in Toxicology

Volumn 22, Issue 2, 2009, Pages 323-331

  Kuribayashi, Shunji ^a   Goto, Kiyoto ^a   Naito, Shinsaku ^a   Kamataki, Tetsuya ^b   Yamazaki, Hiroshi ^a,c  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 N BUTYL 7 (3,4,5 TRIMETHOXYBENZOYLAMINO)PYRAZOLO[1,5 A]PYRIMIDINE; 5 N BUTYL PYRAZOLO[1,5 A]PYRIMIDINE; AMINO ACID DERIVATIVE; ANTIBODY; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; CYTOCHROME P450 1A2; CYTOCHROME P450 ANTIBODY; DRUG METABOLITE; GLUTATHIONE; HYDROXYL GROUP; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; DRUG METABOLISM; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER; LIVER MICROSOME; LIVER TOXICITY; NONHUMAN; RAT; SPECIES;

ANIMALS; CYSTEINE; CYTOCHROME P-450 CYP1A2; HEPATITIS, TOXIC; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; PYRAZOLES; PYRIMIDINES; RATS; SPECIES SPECIFICITY;

ANIMALIA; RATTUS;

EID: 62249136308     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx8003592     Document Type: Article

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