A new surgical approach to improve gene transfer in liver using lentiviral vectors

Journal of Pediatric Surgery

Volumn 44, Issue 3, 2009, Pages 517-522

  Dariel, Anne ^a   Nguyen, Tuan Huy ^b   Pichard, Virginie ^b   Schmitt, Françoise ^a   Aubert, Dominique ^b   Ferry, Nicolas ^b   Podevin, Guillaume ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

Author keywords

Crigler Najjar; Gene therapy; Lentivirus; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; PREALBUMIN; PROTEIN ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CAVA VEIN; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; FEMALE; GUNN RAT; HEPATIC VEIN; HUMAN; HUMAN CELL; LIVER CELL; LIVER CIRCULATION; MALE; MARKER GENE; NEWBORN; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; REPORTER GENE; SURGICAL APPROACH; SYSTEMIC CIRCULATION; VIRAL GENE DELIVERY SYSTEM; VIRUS EXPRESSION; VIRUS PARTICLE;

ANIMALS; CELL COUNT; CELLS, CULTURED; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; LIVER; LIVER CIRCULATION; MALE; PLASMIDS; RATS; RATS, GUNN; TRANSDUCTION, GENETIC; VENAE CAVAE;

EID: 62149138078     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2008.08.020     Document Type: Article

References (11)

1. Ferry N. Gene therapy and liver diseases. Gastroenterol Clin Biol 27 (2003) 288-290
2. Kafri T., Blomer U., Peterson D.A., et al. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 17 3 (1997) 314-317
3. Nguyen T.H., Belloti-Privato M., Aubert D., et al. Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats. Mol Ther 12 5 (2005) 852-859
4. Nguyen T.H., Aubert D., Bellodi-Privato M., et al. Critical assessment of lifelong phenotype correction in hyperbilirubinemic Gunn rats after retroviral mediated gene transfer. Gene Ther 14 17 (2007) 1270-1277
5. Snoeys J., Lievens J., Wisse E., et al. Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae. Gene Ther 14 7 (2007) 604-612
6. Lievens J., Snoeys J., Vekemans K., et al. The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer. Gene Ther 11 (2004) 1523-1531
7. Nguyen T.H., Oberholzer J., Birraux J., et al. Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes. Mol Ther 6 2 (2002) 199-209
8. Follenzi A., Sabatino G., Lombardo A., et al. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum Gene Ther 13 2 (2002) 243-260
9. Vigna E., Amendola M., Benedicenti F., et al. Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector. Mol Ther 11 5 (2005) 763-775
10. Aubert D., Menoret S., Chiari E., et al. Cytotoxic immune response blunts long-term transgene expression after efficient retroviral-mediated hepatic gene transfer in rat. Mol Ther 5 4 (2002) 388-396
11. Brown B.D., Venneri M.A., Zingale A., et al. Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat Med 12 5 (2006) 585-591