Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities

Genes Chromosomes and Cancer

Volumn 48, Issue 4, 2009, Pages 310-321

  Bentley, Johanne ^a   L'Hôte, Corine ^a   Platt, Fiona ^a   Hurst, Carolyn D ^a   Lowery, Johanna ^a   Taylor, Claire ^a   Sak, Sei C ^a   Harnden, Patricia ^a   Knowles, Margaret A ^a   Kiltie, Anne E ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; KU ANTIGEN; NUCLEOTIDE; PROTEIN P53; CELL NUCLEUS ANTIGEN; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; HELICASE; NUCLEAR PROTEIN; TP53 PROTEIN, HUMAN; XRCC4 PROTEIN, HUMAN; XRCC5 PROTEIN, HUMAN;

ARTICLE; BLADDER TUMOR; CANCER INVASION; CANCER SURGERY; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE SEVERITY; DNA BINDING; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MUSCLE INVASIVE BLADDER TUMOR; PAPILLOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; TUMOR GROWTH; CANCER STAGING; GENETICS; METABOLISM; MOLECULAR GENETICS; MUSCLE; NUCLEOTIDE SEQUENCE; PAPILLARY CARCINOMA; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, NUCLEAR; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, PAPILLARY; CELL LINE, TUMOR; CHROMOSOME ABERRATIONS; COMPARATIVE GENOMIC HYBRIDIZATION; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENOMIC INSTABILITY; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLES; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NUCLEAR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS;

EID: 62149135914     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20641     Document Type: Article

References (40)

1. Andrews BJ, Lehman JA, Turchi JJ. 2006. Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of KU protein. J Biol Chem 281:13596-13603.
2. Audebert M, Salles B, Calsou P. 2004. Involvement of Poly(ADP- ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double strand breaks rejoining. J Biol Chem 279:55117-55126.
3. Audebert M, Salles B, Weinfeld P, Calsou P. 2006. Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1- dependent DNA double strand breaks rejoining pathway. J Mol Biol 356:257-265.
4. Ayene IS, Stamato TD, Mauldin SK, Biaglow JE, Tittle SW, Jenkins SF, Koch CJ. 2002. Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of KU DNA end binding during oxidative stress. J Biol Chem 277:9929-9935.
5. Banerjee S. Smith S, Myung K. 2006. Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints. Proc Natl Acad Sci USA 103:18161821.
6. Bentley J, Diggle CP, Harnden P, Knowles MA, Kiltie AE. 2004. DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res 32:5249-5259.
7. Bullock AN, Henckel J, DeDecker BS, Johnson CM, Nikolova PV, Proctor MR, Lane DP, Fersht AR. 1997. Thermodynamic stability of wild-type and mutant p53 core domain. Proc Natl Acad Sci USA 94:14338-14342.
8. Callebaut I, Mailvert L, Fischer A, Mornon J-P, Revy P, de Villartay J-P. 2006. Cernunnos interacts with the XRCC4 : DNA-ligase IV complex and is homologous to the yeast nonho- mologous end-joining factor Nej1. J Biol Chem 281:1385713860.
9. Capp J-P, Boudsocq F, Bertrand P, Laroche-Clary A, Pourquier P, Lopez BS, Cazaux C, Hoffmann J-S, Canitrot Y. 2006. The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic Acids Res 34:2998-3007.
10. Dahm-Daphi J, Hubbe P, Horvath F, El-Awady RA, Bouffard KE, Powell SN, Willers H. 2005. Nonhomologous end-joining of site-specific but not radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene 24:1663-1672.
11. Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Reid T, Nussenzweig A. 2000. DNA repair protein KU80 suppresses chromosomal aberrations and malignant transformation. Nature 404:510-514.
12. Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A. 2002. Evidence for replica- tive repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med 196:469-480.
13. Diggle CP, Bentley J, Kiltie AE. 2003. Development of a rapid, small-scale DNA repair assay for use on clinical samples. Nucleic Acids Res 31:e83.
14. Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97:6630-6633.
15. Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Smith J, Vetrie D, Gorman P, Tomlinson IP, Carter NP. 2003. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 36:361-374.
16. Freebourg T, Barbier N, Yan YX, Garber JE, Dreyfus M, Frau- meni J, Li FP, Friend SH. 1995. Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome. Am J Hum Genet 56:608-615.
17. Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. 2000. Interplay of
18. p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404:897-900.
19. Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. 2006. KU80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene 25:7159-7165.
20. Hurst CD, Fiegler H, Carr P, Williams S, Carter NP, Knowles MA. 2004. High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization. Oncogene 23:2250-2263.
21. Jaco I, Munoz P, Blasco MA. 2004. Role of human KU86 in telo- mere length maintenance and telomere capping. Cancer Res. 64:7271-7278.
22. Jong K, Marchiori E, Meijer G, Vaart AV, Ylstra B. 2004. Breakpoint identification and smoothing of array comparative genomic hybridization data. Bioinformatics 20:3636-3637.
23. Kabotyanski EB, Gomelsky L, Stamato TD, Roth DB. 1998. Double-strand break repair in KU86- and XRCC4-deficient cells. Nucleic Acids Res 26:5333-5342.
24. Kato S, Han S-Y, Lui W, Otsuka K, Shibata H, Kanamaru R, Ish- ioka C. 2003. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci USA 100:8424-8429. Kelsey KT, Hirao T, Hirao S, Devi-Ashok T, Nelson HH, Andrew A, Colt J, Baris D, Morris JS, Schned A, Karagas M. 2005. TP53 alterations and patterns of carcinogen exposure in a US population-based study of bladder cancer. Int J Cancer 117:370-375.
25. Knowles MA. 2006a. Molecular Biology of Bladder Cancer. In: Waxman J, editor. Urological Cancers. London: Springer-Verlag, pp. 115-130.
26. Knowles MA. 2006b. Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? Carcinogenesis 27:361-373.
27. Kuhfittig-Kulle S, Feldmann E, Odersky A, Kuliczkowska A, Goe- decke W, Eggert A, Pfeiffer P. 2007. The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors KU70/80, DNA-PKcs and XRCC4-LigIV. Mutagen- esis 22:217-233.
28. Lee K, Lee SE. 2007. Saccharomyces cerevisiae Sae2- and Tel1- dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics 176:2003-2014.
29. Li G, Nelsen C, Hendrickson, EA. 2002. KU86 is essential in human somatic cells. Proc Natl Acad Sci USA 99:832-837.
30. Ma J-L, Kim EM, Haber JE, Lee SE. 2003. Yeast Mre11 and Rad1 proteins define a KU-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol 23:8820-8828.
31. Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P. 2002. The IARC TP53 Database: New online mutation analysis and recommendations to users. Hum Mutat 19:607-614. Database version R11 October 2006.
32. Pucci S, Mazzarelli P, Rabitti C, Giai M, Gallucci M, Flammia G, Alcini A, Altomare V, Fazio VM. 2001. Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopsies. Oncogene 20:739-747.
33. Raschke S, Balz V, Efferth T, Schulz WA, Florl AR. 2005. Homo- zygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines. Genes Chromosomes Cancer 42:58-67.
34. Roberts SA, Ramsden, DA. 2007. Loading of the nonhomologous end joining factor KU on protein-occluded DNA ends. J Biol Chem 282:10605-10613.
35. Sasaki S, Kitagawa Y, Sekido Y, Minna JD, Kuwano H, Yokota J, Kohno T. 2003. Molecular processes of chromosome 9p21 deletions in human cancers Oncogene 22:3792-3798.
36. Smith J, Riballo E, Kysela B, Baldeyron C, Manolis K, Masson C, Leiber MR, Papadopoulo D, Jeggo P. 2003. Impact of DNA ligase IV on the fidelity of end-joining in human cells. Nucleic Acids Res 31:2157-2167.
37. Verkaik NS, Esveldt-van Lange REE, van Heemst D, Bruggen- wirth HT, Hoeijmakers JHJ, Zdzienicka MZ, van Gent DC. 2002. Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol 32:701-709.
38. Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. 2006. PARP-1 and KU compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 34:6170-6182.
39. Wang Q, Gao F, May WS, Zhang Y, Flagg T, Deng X. 2008. Bcls negatively regulates DNA double strand break repair through a non-homologous end-joining pathway. Mol Cell 29:488-498.
40. Yoo S, Dynan WS. 1999. Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of KU protein. Nucleic Acids Res 27:4679-4686.