Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid: Selective inhibition by structure-based design

European Journal of Biochemistry

Volumn 270, Issue 22, 2003, Pages 4574-4586

  Ladame, Sylvain ^a,d   Castilho, Marcelo S ^b   Silva, Carlos H T P ^b   Denier, Colette ^a   Hannaert, Véronique ^c   Périé, Jacques ^a   Oliva, Glaucius ^b   Willson, Michèle ^a  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c DE DUVE INSTITUTE   (Belgium)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

1,3 bisphospho D glyceric acid isosteric analogue; Drug design; Glyceraldehyde 3 phosphate dehydrogenase (GAPDH); Trypanosoma cruzi

Indexed keywords

1,3 BIPHOSPHO DEXTRO GLYCERIC ACID; ARGININE; ENZYME INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCERIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHOGLYCERIC ACIDS; DRUG DESIGN; ELECTROSTATICS; ENZYME INHIBITORS; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 0344442882     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03857.x     Document Type: Article

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