The action of bax and bcl-2 on T cell selection

Journal of Experimental Medicine

Volumn 188, Issue 6, 1998, Pages 1125-1133

  Williams, Owen ^a   Norton, Trisha ^a   Halligey, Mark ^a   Kioussis, Dimitris ^a   Brady, Hugh J M ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Apoptosis; Bax; Bcl 2; Fetal thymic organ cultures; Thymic selection

Indexed keywords

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SELECTION; FETUS; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIFFERENTIATION; CELL SEPARATION; FETUS; FLOW CYTOMETRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSGENES;

EID: 0032555909     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.6.1125     Document Type: Article

References (49)

1. Sha, W.C., C.A. Nelson, R.D. Newberry, D.M. Kranz, J.H. Russell, and D.Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 36:73-76.
2. Kisielow, P., H.-S. Teh, H. Bluthmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature. 335:730-733.
3. Teh, H.-S., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluthmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 335: 229-233.
4. Scott, B., H. Bluthmann, H.S. Teh, and H. von Boehmer. 1989. The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens. Nature. 338:591-593.
5. + thymocytes. Nature. 333:742-746.
6. lo thymocytes in vivo. Science. 250:1720-1723.
7. Surh, C.D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature. 372:100-103.
8. Kroemer, G. 1997. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3:614-620.
9. Oltvai, Z., C. Milliman, and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609-619.
10. Sentman, C.L. J.R. Shutter, D. Hockenbery, O. Kanagama, and S.J. Korsmeyer. 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 67: 879-888.
11. Strasser, A., A.W. Harris, and S. Cory. 1991. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 67:889-899.
12. Brady, H.J.M., G.S. Salomons, R.C. Bobeldijk, and A.J.M. Berns. 1996. T cells from baxα transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO (Eur. Mol. Biol. Organ.) J. 15:1221-1230.
13. Pezella, F., A. Tse, J.L. Cordell, K. Pulford, K.C. Gatter, and D.Y. Mason. 1990. Expression of the bcl-2 oncogene is not specific for the 14;18 chromosomal translocation. Am. J. Pathol. 137:2115-2120.
14. Hockenbery, D., M. Zutter, W. Hickey, M. Nahm, and S.J. Korsmeyer. 1991. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA. 88:6961-6965.
15. Gratiot-Deans, J., L. Ding, L.A. Turka, and G. Nunez. 1993. bcl-2 proto-oncogene expression during human T cell development. J. Immunol. 151:83-91.
16. Veis, D.J., C.M. Sorenson, J.R. Shutter, and S.J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair. Cell. 75:229-240.
17. - stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1:197-205.
18. + thymocytes has selectively terminated CD4 or CD8 synthesis. J. Exp. Med. 184:2091-2099.
19. Siegel, R.M., M. Katsumata, T. Miyashita, D.C. Louie, M.L. Greene, and J.C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigen selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA. 89:7003-7007.
20. Strasser, A., A.W. Harris, H. von Boehmer, and S. Cory. 1994. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl. Acad. Sci. USA. 91:1376-1380.
21. + thymocytes is altered by overexpression of the Bcl-2 protooncogene in the thymus. J. Exp. Med. 179:145-153.
22. L displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J. Exp. Med. 182:1973-1983.
23. L prevents bacterial superantigen-induced apoptosis of thymocytes in vitro. Cell Death Differ. 4:159-165.
24. Boise, L.H., M. Gonzalez-Garcia, C.E. Postema, L. Ding, T. Lindsten, L.A. Turka, X. Mao, G. Nunez, and C.B. Thompson. 1993. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74:597-608.
25. Motoyama, N., F. Wang, K.A. Roth, H. Sawa, K.-I. Nakayama, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii, and D.Y. Loh. 1995. Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice. Science. 267:1506-1510.
26. L regulated apoptosis in T cell development. Int. Immunol. 9:1375-1384.
27. Mamalaki, C., T. Norton, Y. Tanaka, A.R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1992. Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 89: 11342-11346.
28. Mamalaki, C., J. Elliot, T. Norton, N. Yannoutsos, A.R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for Influenza nucleoprotein and endogenous superantigen. Dev. Immunol. (NY). 3:159-174.
29. Townsend, A.R.M., A.J. McMichael, N.P. Carter, J.A. Huddleston, and G.G. Brownlee. 1984. Cytotoxic T cell recognition of the Influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell. 39:13-25.
30. Knudson, C.M., and S.J. Korsmeyer. 1997. Bcl-2 and Bax function independently to regulate cell death. Nat. Genet. 16: 358-363.
31. Spanopoulou, E., C.A.J. Roman, L.M. Corcoran, M.S. Schlissel, D.P. Silver, D. Nemazee, M.C. Nussenzweig, S.A. Shinton, R.R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030-1042.
32. McDonnell, T.J., N. Deane, F.M. Platt, G. Nunez, U. Jaeger, J.P. McKearn, and S.J. Korsmeyer. 1989. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79-88.
33. Cobbold, S.P., A. Jayasuriya, A. Nash, T.D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature. 312:548-551.
34. β11-positive mouse T-cell clone. Immunogenetics. 28:445-451.
35. Bendelac, A., P. Matzinger, R.A. Seder, W.E. Paul, and R.H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731-742.
36. + thymocytes. Eur. J. Immunol. 23:739-746.
37. Tanaka, Y., O. Williams, R. Tarazona, A. Wack, T. Norton, and D. Kioussis. 1997. In vitro positive selection of αβ TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone. Int. Immunol. 9:381-393.
38. Clayton, L.K., Y. Ghendler, E. Mizoguchi, R.J. Patch, T.D. Ocain, K. Orth, A.K. Bhan, V.M. Dixit, and E.L. Reinherz. 1997. T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. EMBO (Eur. Mol. Biol. Organ.) J. 16:2282-2293.
39. Martin, S., and M.J. Bevan. 1997. Antigen-specific and non-specific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27:2726-2736.
40. Tarazona, R., O. Williams, D. Moskophidis, L.A. Smyth, Y. Tanaka, M. Murdjeva, A. Wack, C. Mamalaki, and D. Kioussis. 1998. Susceptibility and resistance to antigen induced apoptosis in the thymus of transgenic mice. J. Immunol. 160:5397-5403.
41. Jenkinson, E.J., and G. Anderson. 1994. Fetal thymic organ cultures. Curr. Opin. Immunol. 6:293-297.
42. Conroy, L.A., and D.R. Alexander. 1996. The role of intracellular signalling pathways regulating thymocyte and leukemic T cell apoptosis. Leukemia. 10:1422-1435.
43. Brady, H.J.M., G. Gil-Gomez, J. Kirberg, and A.J.M. Berns. 1996. Baxa perturbs T cell development and affects cell cycle entry of T cells. EMBO (Eur. Mol. Biol. Organ.) J. 15:6991-7001.
44. Strasser, A., A.W. Harris, D.C.S. Huang, P.H. Krammer, and S. Cory. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO (Eur. Mol. Biol. Organ.) J. 14:6136-6147.
45. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
46. Singer, G.G., and A.K. Abbas. 1994. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:365-371.
47. Sytwu, H.K., R.S. Liblau, and H.O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity. 5:17-30.
48. Castro, J.E., J.A. Listman, B.A. Jacobson, Y. Wang, P.A. Lopez, S. Ju, P.W. Finn, and D.L. Perkins. 1996. Fas modulation of apoptosis during negative selection of thymocytes. Immunity. 5:617-627.
49. St. Clair, E.G., S.J. Anderson, and Z.N. Oltavi. 1997. Bcl-2 counters apoptosis by Bax heterodimerization-dependent and -independent mechanisms in the T-cell lineage. J. Biol. Chem. 272:29347-29355.