Synthesis and biological activities of topoisomerase I inhibitors, 6-N- amino analogues of NB-506

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 9, 1999, Pages 1219-1224

  Ohkubo, Mitsuru ^a   Kojiri, Katsuhisa ^a   Kondo, Hisao ^a   Tanaka, Seiichi ^a   Kawamoto, Hiroshi ^a   Nishimura, Teruyuki ^a   Nishimura, Ikuko ^a   Yoshinari, Tomoko ^a   Arakawa, Hiroharu ^a   Suda, Hiroyuki ^a   Morishima, Hajime ^a   Nishimura, Susumu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anticancer agents; Indolocarbazole; Substituent effects; Topoisomerase

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; AMINO ACID DERIVATIVE; DNA TOPOISOMERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CYTOTOXICITY; DNA CLEAVAGE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TEMPERATURE DEPENDENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GLUCOSIDES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MODELS, CHEMICAL; NEOPLASMS, EXPERIMENTAL; PYRROLES; TUMOR CELLS, CULTURED;

EID: 0033519179     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00188-2     Document Type: Article

References (14)

1. (a) Stewart, A. F.; Schutz, G. Cell 1987, 50, 1109.
2. (b) Zhang, H.; Wang, J. C.; Liu, L. F. Proc. Natl. Acad. Sci. USA 1988, 85, 1060.
3. (c) Wu, H-Y.; Shyy, S. H.; Wang, J. C.; Liu, L. F. Cell 1988, 53, 433.
4. (d) Merino, A.; Madden, K. R.; Lane, W. S.; Champoux, J. J.; Reinberg, D. Nature (Lond.) 1993, 365, 227.
5. Morham, S. G.; Kluckman, K. D.; Voulomanos, N.; Smithies, O. Mol. Cell. Biol. 1996, 16, 6804.
6. Husain, I.; Mohler, J. L.; Seigler, H. F.; Besterman, J. M. Cancer Res. 1994, 54, 539.
7. Kojiri, K.; Kondo, H.; Yoshinari, T.; Arakawa, H.; Nakajima, S.; Satoh, F.; Kawamura, K.; Okura, A.; Suda, H.; Okanishi, M. J. Antibiot. 1991, 44, 723.
8. (a) Tanaka, S.; Ohkubo, M.; Kojiri, K.; Suda, H.; Yamada, A.; Uemura, D. J. Antibiot. 1992, 45, 1797.
9. (b) Yoshinari, T.; Yamada, A.; Uemura, D.; Nomura, K.; Arakawa, H.; Kojiri, K.; Yoshida, E.; Okura, A. Cancer Res. 1993, 53, 490.
10. (c) Arakawa, H.; Iguchi, T.; Yoshinari, T.; Kojiri, K.; Suda, H.; Okura, A. Cancer Res. 1993, 84, 574.
11. (a) Arakawa, H.; Iguchi, T.; Morita, M.; Yoshinari, T.; Kojiri, K.; Suda, H.; Okura, A.; Nishimura, S. Cancer Res. 1995, 55, 1316.
12. (b) Yoshinari, T.; Matsumoto, M.; Arakawa, H.; Okada, H.; Noguchi, K.; Suda, H.; Okura, A.; Nishimura, S. Cancer Res. 1995, 55, 1310.
13. (c) Fukasawa, K.; Komatani, H.; Hara, Y.; Suda, H.; Okura, A,;Nishimura, S.; Yoshinari, T. Int. J. Cancer 1998, 75, 145.
14. Ohkubo, M.; Kawamoto, K.; Ohno, T.; Nakano, M.; Morishima, H. Tetrahedron 1997, 53, 585.