Novel therapeutic approach targeting the HIF-HRE system in the kidney

Advances in Experimental Medicine and Biology

Volumn 645, Issue , 2009, Pages 81-86

  Nangaku, Masaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLOR 3 HYDROXYCHINOLIN 2 CARBONIC ACID N CARBOXYMETHYLAMID; ADENOVIRUS VECTOR; COBALT; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MIMOSINE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 2; S 956711; UNCLASSIFIED DRUG; HYPOXIA INDUCIBLE FACTOR 1;

CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME ACTIVATION; GLOMERULONEPHRITIS; HUMAN; HYPOXIA; IN VIVO GENE TRANSFER; KIDNEY INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; VIRAL GENE DELIVERY SYSTEM; ANIMAL; ARTICLE; DNA RESPONSIVE ELEMENT; GENETICS; KIDNEY DISEASE; METABOLISM; MOUSE; MOUSE MUTANT; PROTEIN BINDING; TRANSGENE;

ANIMALS; HYPOXIA-INDUCIBLE FACTOR 1; KIDNEY DISEASES; MICE; MICE, KNOCKOUT; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; RESPONSE ELEMENTS; TRANSGENES;

EID: 61849083011     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-85998-9_13     Document Type: Conference Paper

References (26)

1. M. Nangaku, Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure, J. Am. Soc. Nephrol. 17(1), 17-25(2006)
2. T. Tanaka, T. Miyata, R. Inagi, T. Fujita, and M. Nangaku, Hypoxia in renal disease with proteinuria and/or glomerular hypertension. Am. J. Pathol. 165(6), 1979-92(2004) (Pubitemid 39578376)
3. F. Palm, J. Cederberg, P. Hansell, P. Liss, and P. O. Carlsson, Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension, Diabetologia. 46(8), 1153-60(2003) (Pubitemid 37041246)
4. C. Rosenberger, S. Mandriota, J. S. Jurgensen, M. S. Wiesener, J. H. Horstrup, U. Frei, P. J. Ratcliffe, P. H. Maxwell, S. Bachmann, and K. U. Eckardt, Expression of hypoxia-inducible factor-1 and-2 in hypoxic and ischemic rat kidneys, J. Am. Soc. Nephrol. 13(7), 1721-1732(2002) (Pubitemid 34700596)
5. M. S. Wiesener, J. S. Jurgensen, C. Rosenberger, C. K. Scholze, J. H. Horstrup, C. Warnecke, S. Mandriota, I. Bechmann, U. A. Frei, C. W. Pugh, P. J. Ratcliffe, S. Bachmann, P. H. Maxwell, and K. U. Eckardt, Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs, FASEB J. 17, 271-273(2003)
6. C. Rosenberger, W. Griethe, G. Gruber, M. Wiesener, U. Frei, S. Bachmann, and K. U. Eckardt, Cellular responses to hypoxia after renal segmental infarction, Kidney Int. 64(3), 874-886(2003) (Pubitemid 37013823)
7. C. Rosenberger, S. N. Heyman, S. Rosen, A. Shina, M. Goldfarb, W. Griethe, U. Frei, P. Reinke, S. Bachmann, and K. U. Eckardt, Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia. Kidney Int. 67(2), 531-542(2005) (Pubitemid 40139845)
8. Z. Cai, D. J. Manalo, G. Wei, E. R. Rodriguez, K. Fox-Talbot, H. Lu, J. L. Zweier, and G. L. Semenza GL, Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury, Circulation. 108(1), 79-85(2003) (Pubitemid 36859024)
9. I. Kojima, T. Tanaka, R. Inagi, H. Kato, T. Yamashita, A. Sakiyama, O. Ohneda, N. Takeda, M. Sata, T. Miyata, T. Fujita T, and M. Nangaku, Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney, J. Am. Soc. Nephrol. 18(4), 1218-26(2007) (Pubitemid 46536908)
10. N. Li, F. Yi, C. M. Sundy, L. Chen, M. L. Hilliker, D. K. Donley, D. B. Muldoon, and P. L. Li, Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys, Am. J. Physiol. Renal Physiol. 292(1), F207-16 (2007) (Pubitemid 46105261)
11. C. Willam, P. H. Maxwell, L. Nichols, C. Lygate, Y. M. Tian, W. Bernhardt, M. Wiesener, P. J. Ratcliffe, K. U. Eckardt, and C. W. Pugh, HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation, J. Mol. Cell. Cardiol. 41, 68-77(2006) (Pubitemid 43964933)
12. R. J. Appelhoff, Y. M. Tian, R. R. Raval, H. Turley, A. L. Harris, C. W. Pugh, P. J. Ratcliffe, and J. M. Gleadle, Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor, J. Biol. Chem. 279(37), 38458-38465(2004) (Pubitemid 39295997)
13. K. Takeda, A. Cowan, and G. H. Fong, Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system, Circulation. [Epub ahead of print] (2007)
14. K. Manotham, T. Tanaka, T. Ohse, I. Kojima, T. Miyata, R. Inagi, H. Tanaka, R. Sassa, T. Fujita, and M. Nangaku, A biological role of HIF-1 in the renal medulla, Kidney Int. 67(4), 1428-1439(2005) (Pubitemid 40463119)
15. S. Rajagopalan, J. Olin, S. Deitcher, A. Pieczek, J. Laird, P. M. Grossman, C. K. Goldman, K. McEllin, R. Kelly, and N. Chronos, Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience, Circulation. 115(10), 1234-43(2007) (Pubitemid 46594767)
16. H. F. Gardner, The use of cobaltous chloride in the anemia associated with chronic renal disease. J. Lab. Clin. Med. 41(1), 56-64(1953)
17. M. Matsumoto, Y. Makino, T. Tanaka, H. Tanaka, N. Ishizaka, E. Noiri, T. Fujita, and M. Nangaku, Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats, J. Am. Soc. Nephrol. 14(7), 1825-1832(2003) (Pubitemid 36750477)
18. Y. Kudo, Y. Kakinuma, Y. Mori, N. Morimoto, T. Karashima, M. Furihata, T. Sato, T. Shuin, and T. Sugiura, Hypoxia-inducible factor-1alpha is involved in the attenuation of experimentally induced rat glomerulonephritis, Nephron Exp. Nephrol. 100(2), e95-103 (2005) (Pubitemid 40868657)
19. T. Tanaka, I. Kojima, T. Ohse, J. R. Ingelfinger, S. Adler, T. Fujita, and M. Nangaku, Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model, Lab. Invest. 85(10), 1292-1307(2005) (Pubitemid 41348643)
20. T. Tanaka, I. Kojima, T. Ohse, R. Inagi, T. Miyata, J. R. Ingelfinger, T. Fujita, and M. Nangaku, Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity. Am. J. Physiol. Renal Physiol. 289(5), F1123-1133 (2005)
21. T. Tanaka, M. Matsumoto, R. Inagi, T. Miyata, I. Kojima, T. Ohse, T. Fujita, and M. Nangaku, Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis, Kidney Int. 68(6), 2714-2725(2005) (Pubitemid 43251016)
22. C. Warnecke, W. Griethe, A. Weidemann, J. S. Jurgensen, C. Willam, S. Bachmann, Y. Ivashchenko, I. Wagner, U. Frei, M. Wiesener, and K. U. Eckardt, Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors, FASEB J. 17, 1186-1188(2003)
23. H. Kasiganesan, V. Sridharan, and G. Wright, Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance, Acta Physiol. (Oxf). 190(2), 163-9(2007) (Pubitemid 46776396)
24. W. M. Bernhardt, V. Campean, S. Kany, J. S. Jürgensen, A. Weidemann, C. Warnecke, M. Arend, S. Klaus, V. Günzler, K. Amann, C. Willam, M. S. Wiesener, and K. U. Eckardt, Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure, J. Am. Soc. Nephrol. 17(7), 1970-1978(2006) (Pubitemid 44036181)
25. M. A. McDonough, V. Li, E. Flashman, R. Chowdhury, C. Mohr, B. M. Liénard, J. Zondlo, N. J. Oldham, I. J. Clifton, J. Lewis, L. A. McNeill, R. J. Kurzeja, K. S. Hewitson, E. Yang, S. Jordan, R. S. Syed, and C. J. Schofield, Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2), Proc. Natl. Acad. Sci. 103(26), 9814-9819(2006) (Pubitemid 43993580)
26. E. J. Soilleux, H. Turley, Y. M. Tian, C. W. Pugh, K. C. Gatter, and A. L. Harris AL, Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues, Histopathology. 47(6), 602-610(2005) (Pubitemid 41775183)