Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system

FEBS Letters

Volumn 583, Issue 6, 2009, Pages 960-964

  Zhang, Jie ^a   Sarge, Kevin D ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Bmi 1; Degradation; Proteasome; RING finger; Ubiquitin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BMI1 PROTEIN; CYSTEINE; RING FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN POLYMORPHISM; RING FINGER MOTIF; SINGLE NUCLEOTIDE POLYMORPHISM; UBIQUITINATION;

AMINO ACID SEQUENCE; CELLS, CULTURED; CYSTEINE; CYSTEINE PROTEINASE INHIBITORS; HUMANS; LEUPEPTINS; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DENATURATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RING FINGER DOMAINS; TRANSFECTION; TYROSINE; UBIQUITIN;

EID: 61749101129     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.02.023     Document Type: Article

References (35)

1. Schwartz Y.B., and Pirrotta V. Polycomb complexes and epigenetic states. Curr. Opin. Cell Biol. 20 (2008) 266-273
2. Kanno R., Janakiraman H., and Kanno M. Epigenetic regulator polycomb group protein complexes control cell fate and cancer. Cancer Sci. 99 (2008) 1077-1084
3. Ng R.K., and Gurdon J.B. Epigenetic inheritance of cell differentiation status. Cell Cycle 7 (2008) 1173-1177
4. Kohler C., and Villar C.B. Programming of gene expression by Polycomb group proteins. Trends Cell Biol. 18 (2008) 236-243
5. Pietersen A.M., and van Lohuizen M. Stem cell regulation by polycomb repressors: postponing commitment. Curr. Opin. Cell Biol. 20 (2008) 201-207
6. Mateos-Langerak J., and Cavalli G. Polycomb group proteins and long-range gene regulation. Adv. Genet. 61 (2008) 45-66
7. Haupt Y., Alexander W.S., Barri G., Klinken S.P., and Adams J.M. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 65 (1991) 753-763
8. van Lohuizen M., Verbeek S., Scheijen B., Wientjens E., van der Gulden H., and Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65 (1991) 737-752
9. van Lohuizen M., Frasch M., Wientjens E., and Berns A. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353 (1991) 353-355
10. Brunk B.P., Martin E.C., and Adler P.N. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Nature 353 (1991) 351-353
11. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
12. Jacobs J.J., Scheijen B., Voncken J.W., Kieboom K., Berns A., and van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13 (1999) 2678-2690
13. Fasano C.A., Dimos J.T., Ivanova N.B., Lowry N., Lemischka I.R., and Temple S. ShRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1 (2007) 87-99
14. Dimri G.P., et al. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 62 (2002) 4736-4745
15. van der Lugt N.M., et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8 (1994) 757-769
16. Lessard J., Schumacher A., Thorsteinsdottir U., van Lohuizen M., Magnuson T., and Sauvageau G. Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev. 13 (1999) 2691-2703
17. Park I.K., Qian D., Kiel M., Becker M.W., Pihalja M., Weissman I.L., Morrison S.J., and Clarke M.F. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (2003) 302-305
18. Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
19. Leung C., Lingbeek M., Shakhova O., Liu J., Tanger E., Saremaslani P., Van Lohuizen M., and Marino S. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428 (2004) 337-341
20. Martinez A.M., and Cavalli G. The role of polycomb group proteins in cell cycle regulation during development. Cell cycle 5 (2006) 1189-1197
21. Dovey J.S., Zacharek S.J., Kim C.F., and Lees J.A. Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc. Natl. Acad. Sci. USA 105 (2008) 11857-11862
22. Sangiorgi E., and Capecchi M.R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40 (2008) 915-920
23. Moon J.H., et al. Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1. Biochem. Biophys. Res. Commun. 371 (2008) 267-272
24. Cohen K.J., Hanna J.S., Prescott J.E., and Dang C.V. Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol. Cell. Biol. 16 (1996) 5527-5535
25. Alkema M.J., Jacobs H., van Lohuizen M., and Berns A. Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene 15 (1997) 899-910
26. Hosokawa H., et al. Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177 (2006) 7656-7664
27. Hemenway C.S., Halligan B.W., and Levy L.S. The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene 16 (1998) 2541-2547
28. Lee K., Adhikary G., Balasubramanian S., Gopalakrishnan R., McCormick T., Dimri G.P., Eckert R.L., and Rorke E.A. Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J. Invest. Dermatol. 128 (2008) 9-17
29. Project I.H. A haplotype map of the human genome. Nature 437 (2005) 1299-1320
30. Frazer K.A., et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449 (2007) 851-861
31. Project I.H. The International HapMap Project. Nature 426 (2003) 789-796
32. Ben-Saadon R., Zaaroor D., Ziv T., and Ciechanover A. The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Mol. Cell 24 (2006) 701-711
33. Yamashita M., et al. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205 (2008) 1109-1120
34. Bruggeman S.W., Hulsman D., Tanger E., Buckle T., Blom M., Zevenhoven J., van Tellingen O., and van Lohuizen M. Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 12 (2007) 328-341
35. Dirks P. Bmi1 and cell of origin determinants of brain tumor phenotype. Cancer Cell 12 (2007) 295-297