Evolution of enzymatic activities in the enolase superfamily: Stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes

Biochemistry

Volumn 48, Issue 7, 2009, Pages 1445-1453

  Sakai, Ayano ^a   Fedorov, Alexander A ^b   Fedorov, Elena V ^b   Schnoes, Alexandra M ^c   Glasner, Margaret E ^c   Brown, Shoshana ^c   Rutter, Marc E ^d   Bain, Kevin ^d   Chang, Shawn ^d   Gheyi, Tarun ^d   Sauder, J Michael ^d   Burley, Stephen K ^d   Babbitt, Patricia C ^c   Almo, Steven C ^b   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SGX Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID CATALYSTS; ACTIVE SITES; CARBOXYLATE GROUPS; CYCLOISOMERIZATION; DIVERGENT EVOLUTIONS; DOUBLE BONDS; ENOLASE; ENOLATE ANIONS; ENZYMATIC ACTIVITIES; ENZYME FUNCTIONS; MYCOBACTERIUM SMEGMATIS; PSEUDOMONAS FLUORESCENS; PSEUDOMONAS PUTIDA; SPATIAL ARRANGEMENTS; STRUCTURAL BASIS; SUBSTRATE SPECIFICITIES;

ACIDS; CARBOXYLATION; CATALYSIS; CATALYSTS; COORDINATION REACTIONS; ENZYMES; FUNCTIONAL GROUPS;

SUBSTRATES;

ANION; CARBOXYL GROUP; CARBOXYLIC ACID; ENOLASE; FUNCTIONAL GROUP; MAGNESIUM; MUCONIC ACID; PROTON; ISOMERASE; MUCONATE CYCLOISOMERASE;

ARTICLE; CATALYSIS; CATALYST; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ISOMERIZATION; MOLECULAR EVOLUTION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PSEUDOMONAS FLUORESCENS; PSEUDOMONAS PUTIDA; STEREOCHEMISTRY; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR CLONING; PHYLOGENY; PROTEIN CONFORMATION; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

BIOCATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; INTRAMOLECULAR LYASES; MODELS, MOLECULAR; MYCOBACTERIUM SMEGMATIS; PHOSPHOPYRUVATE HYDRATASE; PHYLOGENY; PROTEIN CONFORMATION; PSEUDOMONAS FLUORESCENS; PSEUDOMONAS PUTIDA; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

MYCOBACTERIUM SMEGMATIS; PSEUDOMONAS FLUORESCENS; PSEUDOMONAS PUTIDA;

EID: 61749098587     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802277h     Document Type: Article

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