Evolutionary potential of (β/α)8-barrels: Stepwise evolution of a "new" reaction in the enolase superfamily

Biochemistry

Volumn 46, Issue 50, 2007, Pages 14589-14597

  Vick, Jacob E ^a   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC GROUPS; EVOLUTIONARY POTENTIAL; O-SUCCINYLBENZOATE SYNTHASE (OSBS);

CATALYST SELECTIVITY; GENE EXPRESSION; MOLECULAR STRUCTURE; REACTION RATES; SUBSTITUTION REACTIONS; SUBSTRATES;

ENZYMES;

ALANINE; ARGININE; ENOLASE; EPIMERASE; LEUCINE; O SUCCINYLBENZOATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; MUTANT; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

BINDING SITES; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHOPYRUVATE HYDRATASE; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 37249087129     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7019063     Document Type: Article

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