Immune cell-derived opioids protect against neuropathic pain in mice (Journal of Clinical Investigation (2009) 119, (278-286) DOI: 10.1172/JCI36246);Immune cell-derived opioids protect against neuropathic pain in mice

Journal of Clinical Investigation

Volumn 119, Issue 2, 2009, Pages 278-286

  Labuz, Dominika ^a   Schmidt, Yvonne ^a   Schreiter, Anja ^a   Rittner, Heike L ^a   Mousa, Shaaban A ^a   Machelska, Halina ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALOXONE; BETA ENDORPHIN; CORTICOTROPIN RELEASING FACTOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; DYNORPHIN A; METENKEPHALIN; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NORBINALTORPHIMINE; OPIATE; OPIATE PEPTIDE; OPIATE RECEPTOR;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CELL STIMULATION; CONTROLLED STUDY; FLOW CYTOMETRY; GRANULOCYTE; IMMUNOCOMPETENT CELL; MACROPHAGE; MALE; MECHANICAL STIMULATION; MONOCYTE; MOUSE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TARGET CELL; ANIMAL; C57BL MOUSE; LEUKOCYTE; METABOLISM; PAIN; PERIPHERAL NEUROPATHY; PHYSIOLOGY;

ANIMALS; CORTICOTROPIN-RELEASING HORMONE; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; OPIOID PEPTIDES; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; RECEPTORS, OPIOID;

EID: 61749085986     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34682C1     Document Type: Erratum

References (48)

1. Sommer, C., and Kress, M. 2004. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci. Lett. 361:184-187.
2. Marchand, F., Perretti, M., and McMahon, S.B. 2005. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 6:521-532.
3. Stein, C., Schäfer, M., and Machelska, H. 2003. Attacking pain at its source: new perspectives on opioids. Nat. Med. 9:1003-1008.
4. Machelska, H. 2007. Targeting of opioid-producing leukocytes for pain control. Neuropeptides. 41:285-293.
5. Stein, C., et al. 1990. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl. Acad. Sci. U. S. A. 87:5935-5939.
6. Stein, C., Hassan, A.H., Lehrberger, K., Giefing, J., and Yassouridis, A. 1993. Local analgesic effect of endogenous opioid peptides. Lancet. 342:321-324.
7. Rittner, H.L., et al. 2001. Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain. Anesthesiology. 95:500-508.
8. Mousa, S.A., Shakibaei, M., Sitte, N., Schäfer, M., and Stein, C. 2004. Subcellular pathways of betaendorphin synthesis, processing, and release from immunocytes in inflammatory pain. Endocrinology. 145:1331-1341.
9. Machelska, H., Cabot, P.J., Mousa, S.A., Zhang, Q., and Stein, C. 1998. Pain control in inflammation governed by selectins. Nat. Med. 4:1425-1428.
10. Machelska, H., Mousa, S.A., Brack, A., Schopohl, J.K., Rittner, H.L., Schäfer, M., and Stein, C. 2002. Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J. Neurosci. 22:5588-5596.
11. Machelska, H., et al. 2004. Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain. Br. J. Pharmacol. 142:772-780.
12. Brack, A., et al. 2004. Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells. Pain. 112:229-238.
13. Schäfer, M., Carter, L., and Stein, C. 1994. Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc. Natl. Acad. Sci. U. S. A. 91:4219-4223.
14. Cabot, P.J., et al. 1997. Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. J. Clin. Invest. 100:142-148.
15. Cabot, P.J., Carter, L., Schäfer, M., and Stein, C. 2001. Methionine-enkephalin-and dynorphin Arelease from immune cells and control of inflammatory pain. Pain. 93:207-212.
16. Labuz, D., et al. 2006. Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain. J. Neurosci. 26:4350-4358.
17. Likar, R., et al. 2007. Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation. Clin. J. Pain. 23:136-142.
18. Scholz, J., and Woolf, C.J. 2002. Can we conquer pain? Nat. Neurosci. 5:1062-1067.
19. Dworkin, R.H., et al. 2007. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 132:237-251.
20. Stein, C., and Kopf, A. 2009. Anesthesia and treatment for chronic pain. In Miller's anesthesia. 7th edition. R.D. Miller, editor. Elsevier. Philadelphia, Pennsylvania, USA. In press.
21. Watkins, L.R., and Maier, S.F. 2002. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol. Rev. 82:981-1011.
22. Moalem, G., and Tracey, D.L. 2006. Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 51:240-264.
23. Cui, J.G., Holmin, S., Mathiesen, T., Meyerson, B.A., and Linderoth, B. 2000. Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy. Pain. 88:239-248.
24. Perkins, N.M., and Tracey, D.J. 2000. Hyperalgesia due to nerve injury: role of neutrophils. Neuroscience. 101:745-757.
25. Stremmel, C., Horn, C., Eder, S., Dimmler, A., and Lang, W. 2005. The impact of immunological parameters on the development of phantom pain after major amputation. Eur. J. Vasc. Endovasc. Surg. 30:79-82.
26. Wagner, R., Janjingian, M., and Myers, R.R. 1998. Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-alpha expression. Pain. 74:35-42.
27. Moalem, G, Xu, K., and Yu, L. 2004. T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats. Neuroscience. 129:767-777.
28. Murphy, P.G., et al. 1999. Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur. J. Neurosci. 11:2243-2253.
29. Liu, T., van Rooijen, N., and Tracey, D.J. 2000. Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. Pain. 86:25-32.
30. Abbadie, C., et al. 2003. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. U. S. A. 100:7947-7952.
31. Honore, P., et al. 2006. Interleukin-1alpha beta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain. Behav. Brain Res. 167:355-364.
32. Bennett, G.J., and Xie, Y.K. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:87-107.
33. Sommer, C., and Schäfers, M. 1998. Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res. 784:154-162.
34. Mousa, S.A., Bopaiah, C.P., Richter, J.F., Yamdeu, R.S., and Schäfer, M. 2007. Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides. Neuropsychopharmacology. 32:2530-2542.
35. Von Andrian, U.H., and Mackay, C.R. 2000. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343:1020-1034.
36. Lewanowitsch, T., and Irvine, R.J. 2002. Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal. Eur. J. Pharmacol. 445:61-67.
37. Dellemijn, P. 1999. Are opioids effective in relieving neuropathic pain? Pain. 80:453-462.
38. Obara, I., et al. 2007. Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat. Eur. J. Pharmacol. 558:60-67.
39. Agarwal, N., et al. 2007. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat. Neurosci. 10:870-879.
40. Gupta, A., Décaillot, F.M., and Devi, L.A. 2006. Targeting opioid receptor heterodimers: strategies for screening and drug development. AAPS J. 8:E153-E159.
41. Chirathaworn, C., et al. 2002. Stimulation through intercellular adhesion molecule-1 provides a second signal for T cell activation. J. Immunol. 168:5530-5537.
42. Kleinschnitz, C., et al. 2006. T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression. Exp. Neurol. 200:480-485.
43. Zuo, Y., Perkins, N.M., Tracey, D.J., and Geczy, C.L. 2003. Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells. Pain. 105:467-479.
44. Perry, V.H., Brown, M.C., and Gordon, S. 1987. The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. J. Exp. Med. 165:1218-1223.
45. Rapalino, O., et al. 1998. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4:814-821.
46. Kerschensteiner, M., et al. 1999. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J. Exp. Med. 189:865-870.
47. Childs, E.A., et al. 1999. Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy. Neurology. 52:607-613.
48. Rutkowski, M.D., et al. 2000. Limited role of macrophages in generation of nerve injury-induced mechanical allodynia. Physiol. Behav. 71:225-235.