Evaluation and implementation of a commercially available mass-guided SFC purification platform in a high throughput purification laboratory in drug discovery

Journal of Liquid Chromatography and Related Technologies

Volumn 32, Issue 4, 2009, Pages 483-499

  McClain, Ray T ^a   Dudkina, Anna ^a   Barrow, James ^a   Hartman, George ^a   Welch, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drug discovery; High throughput; Mass guided SFC; Preparative SFC; Purification; SFC MS

Indexed keywords

ADSORPTION; CHROMATOGRAPHIC ANALYSIS; PURIFICATION; TURNAROUND TIME;

DRUG DISCOVERY; HIGH THROUGHPUT; MASS GUIDED SFC; PREPARATIVE SFC; SFC-MS;

THROUGHPUT;

2,2 DIPHENYLETHANOL; ACETAZOLAMIDE; ALCOHOL; BUMETANIDE; DIMETHYLAMINOPYRIDINE; IBUPROFEN; KETOPROFEN; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ADSORPTION CHROMATOGRAPHY; ARTICLE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

EID: 61649121926     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802671325     Document Type: Article

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