Comparison of preparative HPLC/MS and preparative SFC techniques for the high-throughput purification of compound libraries

Journal of Combinatorial Chemistry

Volumn 6, Issue 2, 2004, Pages 175-180

  Searle, Philip A ^a   Glass, Keithney A ^a   Hochlowski, Jill E ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MASS SPECTROMETRY; ORGANIC CHEMISTRY; PURIFICATION; QUANTUM YIELD; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS;

EID: 1842454320     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc0340372     Document Type: Article

References (28)

1. Ripka, W. C.; Barker, G.; Krakover, J. Drug Discovery Today 2001, 6, 471-477.
2. Cork, D.; Hird, N. Drug Discovery Today 2002, 7, 56-63.
3. Nilsson, U. J. J. Chromatogr., A 2000, 885, 305-319.
4. Peng, S. X.; Henson, C.; Strojnowski, M. J.; Golebiowski, A.; Klopfenstein, S. R. Anal. Chem. 2000, 72, 261-266.
5. Breitenbucher, J. G.; Arienti, K. L.; McClure, K. J. J. Comb. Chem. 2001, 3, 528-533.
6. Ley, S. V.; Baxendale, I. R.; Bream, R. N.; Jackson, P. S.; Leach, A. G. ; Longbottom, D. A.; Nesi, M.; Scott, J. S.; Storer, R. I.; Taylor S. J. J. Chem. Soc., Perkin Trans. 1 2000, 3815-4195.
7. Studer, A.; Hadida, S.; Ferritto, R.; Kim, S.-Y.; Jeger, P.; Wipf, P.; Curran, D. P. Science 1997, 275, 823-826.
8. Curran, D. P. Synlett 2001, 1488-1496.
9. Weller, H. N.; Young, M. G.; Michalczyk, S. J.; Reitnauer, G. H.; Cooley, R. S.; Rahn, P. C.; Loyd, D. J.; Fiore, D.; Fischman, S. J. Mol. Diversity 1997, 3, 61-70.
10. Zeng, L.; Burton, L.; Yung, K.; Shushan, B.; Kassel, D. B. J. Chromatogr., A 1998, 794, 3-13.
11. Leister, W.; Strauss, K.; Wisnoski, D.; Zhao, Z.; Lindsley, C. J. Comb. Chem. 2003, 5, 322-329.
12. Cai, H.; Kiplinger, J. P.; Goetzinger, W. K.; Cole, R. O.; Laws, K. A.; Foster, M.; Schrock, A. Rapid Commun. Mass Spectrom. 2002, 16, 544-554.
13. Edwards, C.; Hunter, D. J. J. Comb. Chem. 2003, 5, 61-66.
14. Zeng, L.; Kassel, D. B. Anal. Chem. 1998, 70, 4380-4388.
15. Xu, R.; Wang, T.; Isbell, J.; Cai, Z.; Sykes, C.; Brailsford, A.; Kassel, D. B. Anal. Chem. 2002, 74, 3055-3062.
16. Isbell, J.; Xu, R.; Cai, Z.; Kassel, D. B. J. Comb. Chem. 2002, 4, 600-611.
17. Berger, T. A. Packed Column SFC, 1st ed; The Royal Society of Chemistry: London, 1995.
18. Berger, T. A.; Wilson, W. H. J. Biochem. Biophys. Methods 2000, 43, 77-85.
19. Ventura, M. C.; Farrell, W. P.; Aurigemma, C. M.; Grieg, M. J. Anal. Chem. 1999, 71, 2410-2416.
20. Ventura, M. C.; Farrell, W. P.; Aurigemma, C. M.; Grieg, M. J. Anal. Chem. 1999, 71, 4223-4231.
21. Berger, T. A.; Fogleman, K.; Staats, T.; Bente, P.; Crocket, I.; Farrell, W.; Osonubi, M. J. Biochem. Biophys. Methods 2000, 43, 87-111.
22. Maiefski, R.; Wendell, D.; Ripka, W. D.; Krakover, J. D. Apparatus and method for multiple channel high throughput purification. PCT Int. Appl. WO 0026662, 2000.
23. Wang, T.; Barber, M.; Hardt, I.; Kassel, D. B. Rapid Commun. Mass Spectrom. 2001, 15, 2067-2075.
24. Olson, J.; Pan, J.; Hochlowski, J.; Searle, P.; Blanchard, D. JALA 2002, 7, 69-74.
25. Hochlowski, J.; Olson, J.; Pan, J.; Sauer, D.; Searle, P.; Sowin, T. J. Liq. Chromatogr. Relat. Technol. 2003, 26, 333-354.
26. Sauer, D. R. Development and Implementation of a High-throughput Organic Synthesis (HTOS) Service for Drug Discovery. Advancing Library Design and Organic Synthesis Conference, La Jolla, CA, February 2003.
27. Searle, P. A. An Automated Preparative HPLC - MS System for the Rapid Purification of Combinatorial Libraries. Strategic Research Institute Conference on High-Throughput Compound Characterization and Purification, Dallas, TX, March 1998.
28. Hochlowski, J.; Cheng X.; Sauer D.; Djuric, S. J. Comb. Chem. 2003, 5, 345-349.