Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome

European Journal of Immunology

Volumn 33, Issue 4, 2003, Pages 834-839

  Simon, Hans Uwe ^a   Plötz, Sabine ^b   Simon, Dagmar ^a   Seitzer, Ulrike ^c   Braathen, Lasse R ^a   Menz, Günter ^d   Straumann, Alex ^e   Dummer, Reinhard ^f   Levi Schaffer, Francesca ^g  

^a UNIVERSITY OF BERN   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

^d High Altitude Clinic Davos Wolfgang   (Switzerland)

^e Kantonsspital Olten ^*  (Switzerland)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Degranulation; Eosinophil; Hypereosinophilia; IL 2; Priming

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; CARBOPLATIN; EOSINOPHIL CATIONIC PROTEIN; ERYTHROPOIETIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; METHOTREXATE; PREDNISONE; THROMBOCYTE ACTIVATING FACTOR; VINBLASTINE;

ALPHA CHAIN; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DEGRANULATION; DRUG RESPONSE; EOSINOPHIL; ESOPHAGITIS; HEART INJURY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HYPEREOSINOPHILIA; LUNG INJURY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN SECRETION; SKIN DEFECT; WELLS SYNDROME;

ASTHMA; BLOOD PROTEINS; CELL DEGRANULATION; DERMATITIS, ATOPIC; DRUG SYNERGISM; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILIA; EOSINOPHILS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPEREOSINOPHILIC SYNDROME; INTERLEUKIN-2; INTERLEUKIN-5; PLATELET ACTIVATING FACTOR; RECEPTORS, INTERLEUKIN-2; RIBONUCLEASES; SYNDROME;

EID: 0037731340     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323727     Document Type: Article

References (27)

1. Meeusen, E. N. and Balic, A., Do eosinophils have a role in the killing of helminth parasites? Parasitol. Today 2000. 16: 95-101.
2. Lee, N. A., Gelfand, E. W. and Lee, J. J., Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J. Allergy Clin. Immunol. 2001. 107: 945-957.
3. Yousefi, S., Hemmann, S., Weber, M., Hölzer, C., Hartung, K., Blaser, K. and Simon, H.-U., IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J. Immunol. 1995. 154: 5481-5490.
4. Schmid-Grendelmeier, P., Altznauer, F., Fischer, B., Bizer, C., Straumann, A., Menz, G., Blaser, K., Wüthrich, B. and Simon, H.-U., Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J. Immunol. 2002. 169: 1021-1027.
5. Bochner, B. S., Systemic activation of basophils and eosinophils. J. Allergy Clin. Immunol. 2000. 106: S292-S302.
6. Riedel, D., Lindemann, A., Brach, M., Mertelsmann, R. and Herrmann, F., Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce surface expression of interleukin-2 receptor p55-chain and CD4 by human eosinophils. Immunol. 1990. 70: 258-261.
7. Taniguchi, T. and Minami, Y., The IL-2/IL-2 receptor system: a current overview. Cell 1993. 75: 5-8.
8. Gruss, H. J., Scott, C., Rollins, B. J., Brach, M. A. and Herrmann, F., Human fibroblasts express functional IL-2 receptors formed by the IL-2R α- and β-chain subunit. Association of IL-2 binding with secretion of the monocyte chemoattractant protein-1. J. Immunol. 1996. 157: 851-857.
9. Ciacci, C., Mahida, Y. R., Dignass, A., Koizumi, M. and Podolsky, D. K., Functional interleukin-2 receptors on intestinal epithelial cells. J. Clin. Invest. 1993. 92: 527-532.
10. Espinoza-Delgado, I., Ortaldo, J. R., Winkler-Pickett, R., Sugamura, K., Varesio, L. and Longo, D. L., Expression and role of p75 interleukin-2 receptor on human monocytes. J. Exp. Med. 1990. 171: 1821-1826.
11. Pericle, F., Liu, J. H., Diaz, J. I., Blanchard, D. K., Wei, S., Forni, G. and Djeu, J. Y., Interleukin-2 prevention of apoptosis in human neutrophils. Eur. J. Immunol. 1994. 24: 440-444.
12. Rand, T. H., Silberstein, D. S., Kornfeld, H. and Weller, P. F., Human eosinophils express functional interleukin 2 receptors. J. Clin. Invest. 1991. 88: 825-832.
13. Simon, H.-U., Plötz, S. G., Dummer, R. and Blaser, K., Abnormal clones of T cells producing interleukin 5 in idiopathic eosinophilia. N. Engl. J. Med. 1999. 341: 1112-1120.
14. Weller, P. F. and Bubley, G. J., The idiopathic hypereosinophilic syndrome. Blood 1994. 83: 2759-2779.
15. Oehling, A. G., Akdis, C. A., Schapowal, A., Blaser, K., Schmitz, M. and Simon, H.-U., Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma. Allergy 1997. 52: 144-154.
16. Gratzl, S., Palca, A., Schmitz, M. and Simon, H.-U., Treatment with IFN-α in corticosteroid-unresponsive asthma. J. Allergy Clin. Immunol. 2000. 105: 1035-1036.
17. Hamid, Q., Azzawi, M., Ying, S., Moqbel, R., Wardlaw, A. J., Corrigan, C. J., Bradley, B., Durham, S. R., Collins, J. V., Jeffery, P. K., Quint, D. J. and Kay, A. B., Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 1991. 87: 1541-1546.
18. Akdis, C. A., Akdis, M., Simon, D., Dibbert, B., Weber, M., Gratzl, S., Kreyden, O., Disch, R., Wüthrich, B., Blaser, K. and Simon, H.-U., T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J. Invest. Dermatol. 1999. 113: 628-634.
19. Simon, H.-U., Weber, M., Becker, E., Zilberman, Y., Blaser, K. and Levi-Schaffer, F., Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J. Immunol. 2000. 165: 4069-4075.
20. Yousefi, S., Hoessli, D. C., Blaser, K., Mills, G. B. and Simon, H.-U., Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 1996. 183: 1407-1414.
21. Simon, H.-U., Yousefi, S., Dibbert, B., Levi-Schaffer, F. and Blaser, K., Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. 1997. 27: 3536-3539.
22. Peters, M. S., Schroeter, A. L. and Gleich, G. J., Immunofluorescence identification of eosinophil granule major basic protein in the flame figures of Wells' syndrome. Br. J. Dermatol. 1983. 109: 141-148.
23. Aberer, W., Konrad, K. and Wolff, K., Wells' syndrome is a distinctive entity and not a histologic diagnosis. J. Am. Acad. Dermatol. 1988. 18: 105-114.
24. Dibbert, B., Weber, M., Nikolaizik, W. H., Vogt, P., Schöni, M. H., Blaser, K. and Simon, H.-U., Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc. Natl. Acad. Sci. USA 1999. 96: 13330-13335.
25. Daigle, I., Yousefi, S., Colonna, M., Green, D. R. and Simon, H.-U., Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat. Med. 2002. 8: 61-67.
26. Hansel, T. T., De Vries, I. J., Iff, T., Rihs, S., Wandzilak, M., Betz, S., Blaser, K. and Walker, C., An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Meth. 1991. 145: 105-110.
27. Simon, H.-U., Yousefi, S., Schranz, C., Schapowal, A., Bachert, C. and Blaser, K., Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J. Immunol. 1997. 158: 3902-3908.