Role for Bcl-x(L) in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5

Blood

Volumn 92, Issue 3, 1998, Pages 778-783

  Dibbert, Birgit ^b   Daigle, Isabelle ^b   Braun, Doris ^b   Schranz, Corinna ^b   Blaser, Martina Weber Kurt ^b   Zangemeister Wittke, Uwe ^b   Akbar, Arne N ^b   Simon, Hans Uwe ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 5; ANTISENSE OLIGONUCLEOTIDE; BAX PROTEIN, HUMAN; BCL2 RELATED PROTEIN A1; BCL2-RELATED PROTEIN A1; BCL2L1 PROTEIN, HUMAN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; MATA1 PROTEIN, S CEREVISIAE; MESSENGER RNA; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; REPLICATION FACTOR C; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ALLERGY; APOPTOSIS; ARTICLE; ATOPIC DERMATITIS; CELL INFILTRATION; CONTROLLED STUDY; EOSINOPHIL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; BIOSYNTHESIS; BLADDER TUMOR; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; NOSE POLYP; PATHOLOGY; PHYSIOLOGY; TRANSITIONAL CELL CARCINOMA;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CARCINOMA, TRANSITIONAL CELL; DERMATITIS, ATOPIC; DNA-BINDING PROTEINS; EOSINOPHILS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-5; NASAL POLYPS; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPLICATION PROTEIN C; REPRESSOR PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; URINARY BLADDER NEOPLASMS;

EID: 0032129211     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.3.778.415k38_778_783     Document Type: Article

References (18)

1. Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K: Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158:3902,1997
2. Bousquet J, Chanez P, Lacoste JY, Barnéon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, Michel FB: Eosinophilic inflammation in asthma. N Engl J Med 323:1033, 1990
3. Simon HU, Blaser K: Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia? Immunol Today 16:53,1995
4. Yang E, Korsmeyer SJ: Molecular thanatopsis: A discourse on the BCL2 family and cell death. Blood 88:386,1996
5. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597,1993
6. Karsan A, Yee E, Kaushansky K, Harlan JM: Cloning of a human Bcl-2 homologue: Inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 87:3089,1996
7. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609,1993
8. Ochiai K, Kagami M, Matsumura R, Tomioka H: IL-5 but not interferon-gamma (IFN-γ) inhibits eosinophil apoptosis by upregulation of bcl-2 expression. Clin Exp Immunol 107:198,1997
9. Saita N, Yamanaka T, Kohrogi H, Matsumoto M, Suga M, Ando M, Hirashima M: Expression of apoptosis-related antigen on eosinophils in chronic eosinophilic pneumonia. Int Arch Allergy Immunol 114:64, 1997(suppl 1)
10. Druilhe A, Arock M, Le Goff L, Pretolani M: Human eosinophils express Bcl-2 family proteins: Modulation of Mcl-1 expression by IFN-γ Am J Respir Cell Mol Biol 18:315,1998
11. Yousefi S, Hemmann S, Weber M, Hölzer C, Hartung K, Blaser K, Simon HU: IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J Immunol 154:5481,1995
12. - T cells associated with abnormal Fas expression and hypereosinophilia. J Exp Med 183:1071,1996
13. Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU: Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 183:1407,1996
14. Hebestreit H, Yousefi S, Balatti I, Weber M, Crameri R, Simon D, Hartung K, Schapowal A, Blaser K, Simon HU: Expression and function of the Fas receptor on human blood and tissue eosinophils. Eur J Immunol 26:1775,1996
15. Ziegler A, Luedke GH, Fabbro D, Altmann KH, Stahel RA, Zangemeister-Wittke U: Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the bcl-2 coding sequence. J Natl Cancer Inst 89:1027,1997
16. s) gene expression. Eur J Immunol 26:294,1996
17. L regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627,1997
18. Simon HU: Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation. Cell Death Diff 3:349,1996