Family-based analysis of tumor necrosis factor and lymphotoxin-α tag polymorphisms with type 1 diabetes in the population of South Croatia

Human Immunology

Volumn 70, Issue 3, 2009, Pages 195-199

  Boraska, Vesna ^a   Zeggini, Eleftheria ^b,c   Groves, Christopher J ^d   Rayner, Nigel W ^b   Škrabić, Veselin ^e   Diakite, Mahamadou ^b   Rockett, Kirk A ^b   Kwiatkowski, Dominic ^b,c   McCarthy, Mark I ^b,d   Zemunik, Tatijana ^a  

^a UNIVERSITY OF SPLIT   (Croatia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY HOSPITAL SPLIT   (Croatia)

Author keywords

Lymphotoxin alpha; Tag polymorphism; TDT; Tumor necrosis factor; Type 1 diabetes

Indexed keywords

LYMPHOTOXIN; TUMOR NECROSIS FACTOR;

ARTICLE; CONTROLLED STUDY; CROATIA; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VERTICAL TRANSMISSION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CROATIA; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LYMPHOTOXIN-ALPHA; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 61549087771     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.12.010     Document Type: Article

References (39)

1. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 29 Suppl (2006) S43-S48
2. Nejentsev S., Howson J.M., Walker N.M., Szeszko J., Field S.F., Stevens H.E., et al., Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450 (2007) 887-892
3. Rich S.S., Concannon P., Erlich H., Julier C., Morahan G., Nerup J., et al. The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci 1079 (2006) 1-8
4. Smyth D.J., Cooper J.D., Bailey R., Field S., Burren O., Smink L.J., et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 38 (2006) 617-619
5. Todd J.A., Walker N.M., Cooper J.D., Smyth D.J., Downes K., Plagnol V., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39 (2006) 857-864
6. Noble J.A., Valdes A.M., Lane J.A., Green A.E., and Erlich H.A. Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-α polymorphisms on type 1 diabetes susceptibility. Hum Immunol 67 (2006) 999-1002
7. Feugeas J.P., Caillens H., Poirier J.C., Charron D., Marcelli-Barge A., and Wautier J.L. Influence of metabolic and genetic factors on tumor necrosis factor-α and lymphotoxin-α production in insulin-dependent diabetes mellitus. Diabetes Metab 23 (1997) 295-301
8. Makhatadze N.J. Tumor necrosis factor locus: Genetic organisation and biological implications. Hum Immunol 59 (1998) 571-579
9. Kim K.A., Kim S., Chang I., Kim G.S., Min Y.K., Lee M.K., et al. IFN gamma/TNF alpha synergism in MHC class II induction: Effect of nicotinamide on MHC class II expression but not on islet-cell apoptosis. Diabetologia 45 (2002) 385-393
10. Yang X.D., Tisch R., Singer S.M., Cao Z.A., Liblau R.S., Schreiber R.D., et al. Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 180 (1994) 995-1004
11. Rabinovitch A., and Suarez-Pinzon W.L. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 55 (1998) 1139-1149
12. Vaux D.L., and Flavell R.A. Apoptosis genes and autoimmunity. Curr Opin Immunol 12 (2000) 719-724
13. Middlebrook A.J., Lebsack T., and DeLuca D. TNF-alpha mediated modulation of T cell development and exacerbation of in vitro T1DM in fetal thymus organ culture. J Autoimmun 29 (2007) 134-145
14. De Togni P., Goellner J., Ruddle N.H., Streeter P.R., Fick A., Mariathasan S., et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264 (1994) 703-707
15. Takahashi K., Satoh J., Seino H., Zhu X.P., Sagara M., Masuda T., et al. Prevention of type I diabetes with lymphotoxin in BB rats. Clin Immunol Immunopathol 69 (1993) 318-323
16. Deja G., Jarosz-Chobot P., Polańska J., Siekiera U., and Małecka-Tendera E. Is the association between TNF-alpha-308 A allele and DMT1 independent of HLA-DRB1, DQB1 alleles?. Mediators Inflamm 2006 (2006) 1-7
17. Das S.N., Baniasadi V., and Kapuria V. Association of -308 TNF-alpha promoter polymorphism with type 1 diabetes in North Indians. Int J Immunogenet 33 (2006) 411-416
18. Bouqbis L., Akhayat O., Garchon H.J., Calafell F., and Izaabel H. TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population. Tissue Antigens 61 (2003) 72-79
19. Kumar R., Goswami R., Agarwal S., Israni N., Singh S.K., and Rani R. Association and interaction of the TNF-alpha gene with other pro- and anti-inflammatory cytokine genes and HLA genes in patients with type 1 diabetes from North India. Tissue Antigens 69 (2007) 557-567
20. Krikovszky D., Vásárhelyi B., Tóth-Heyn P., Körner A., Tulassay T., and Madácsy L. Association between G-308A polymorphism of the tumor necrosis factor-alpha gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents. Clin Genet 62 (2002) 474-477
21. Deng G.Y., Maclaren N.K., Huang H.S., Zhang L.P., and She J.X. No primary association between the 308 polymorphism in the tumor necrosis factor alpha promoter region and insulin-dependent diabetes mellitus. Hum Immunol 5 (1996) 137-142
22. Stayoussef M., Al-Jenaidi F.A., Al-Abbasi A., Al-Ola K., Khayyat H., Mahjoub T., et al. Modulation of type 1 diabetes susceptibility by TNFα -308G/A and lymphotoxin α +249A/G haplotypes in Bahraini patients: Lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes. Clin Vaccine Immunol 15 (2008) 379-381
23. Hanchard N., Rockett K., Udalova I., Wilson J., Keating B., Koch O., et al. An investigation of transmission ratio distortion in the central region of the human MHC. Genes Immun 7 (2006) 51-58
24. Hanchard N., Diakite M., Koch O., Keating B., Pinder M., Jallow M., et al. Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III. Immunogenetics 58 (2006) 465-470
25. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: A toolset for whole genome association and population-based linkage analysis. Am J Hum Genet 81 (2007) 559-575
26. Wigginton J.E., and Abecasis G.R. PEDSTATS: Descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 21 (2005) 3445-3447
27. International HapMap Consortium. The International HapMap project. Nature 426 (2005) 789-796
28. de Bakker P.I., Yelensky R., Pe'er I., Gabriel S.B., Daly M.J., and Altshuler D. Efficiency and power in genetic association studies. Nat Genet 37 (2005) 1217-1223
29. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 (2003) 115-121
30. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
31. Gauderman W.J. Candidate gene association studies for a quantitative trait, using parent-offspring trios. Genet Epidemiol 25 (2003) 327-338
32. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
33. Hamaguchi K., Kimura A., Seki N., Higuchi T., Yasunaga S., Takahashi M., et al. Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese. Tissue Antigens 55 (2000) 10-16
34. Kroeger K.M., Carville K.S., and Abraham L.J. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 34 (1997) 391-399
35. Kaluza W., Reuss E., Grossmann S., Hug R., Schopf R.E., Galle P.R., et al. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism. J Invest Dermatol 114 (2000) 1180-1183
36. Nishimura M., Obayashi H., Mizuta I., Hara H., Adachi T., Ohta M., et al. TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes. Hum Immunol 64 (2003) 302-309
37. Wilson A.G., Symons J.A., McDowell T.L., McDevitt H.O., and Duff G.W. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 94 (1997) 3195-3199
38. Knight J.C., Keating B.J., Rockett K.A., and Kwiatkowski D.P. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet 33 (2003) 469-475
39. Zeggini E., Groves C.J., Parkinson J.R., Halford S., Owen K.R., Frayling T.M., et al. Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. Diabetologia 48 (2005) 2013-2017