Isothiocyanates repress estrogen receptor α expression in breast cancer cells

Oncology Reports

Volumn 21, Issue 1, 2009, Pages 185-192

  Kang, Lianguo ^a   Ding, Ling ^b   Wang, Zhao Yi ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Breast cancer; Estrogen receptor; Isothiocyanate

Indexed keywords

BENZYL ISOTHIOCYANATE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; PHENETHYL ISOTHIOCYANATE; PROTEIN PS2; ANTINEOPLASTIC AGENT; ISOTHIOCYANIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BREAST TUMOR; CELL PROLIFERATION; DRUG EFFECT; FEMALE; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; ISOTHIOCYANATES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 61449430731     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000206     Document Type: Article

References (36)

1. Imamov O, Shim GJ, Warner M and Gustafsson JA: Estrogen receptor beta in health and disease. Biol Reprod 73: 866-871, 2005.
2. Behrens D, Gill JH and Fichtner I: Loss of tumorigenicity of stably ERβ-transfected MCF7 breast cancer cells. Mol Cell Endocrinol 274: 19-29, 2007.
3. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM and Webb P: Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74: 311-317, 2000.
4. Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson JA and Safe S: Ligand-, cell- and estrogen receptor subtype (α/ β)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem 275: 5379-5387, 2000.
5. Block G, Patterson B and Subar A: Fruit, vegetables and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18: 1-29, 1992.
6. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H and van den Brandt PA: Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 5: 733-748, 1996.
7. Xiao D, Vogel V and Singh SV: Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol Cancer Ther 5: 2931-2945, 2006.
8. Tang L and Zhang Y: Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol Cancer Ther 4: 1250-1259, 2005.
9. Fowke JH, Chung FL, Jin F, Qi D, Cai Q, Conaway C, Cheng JR, Shu XO, Gao YT and Zheng W: Urinary isothiocyanate levels, Brassica, and human breast cancer. Cancer Res 63: 3980-3986, 2003.
10. Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zhang Y and Shields PG: Breast Cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr 134: 1134-1138, 2004.
11. Fenwick GR, Heaney RK and Mullin WJ: Glucosinolates and their breakdown products in food and food plants. Crit Rev Food Sci Nutr 18: 123-201, 1983.
12. Getahun SM and Chung FL: Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomarks Prev 8: 447-451, 1999.
13. Talalay P and Fahey JW: Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 131: S3027-S3033, 2001.
14. Zhang Y, Talalay P, Cho CG and Posner GH: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2403, 1992.
15. Mahéo K, Morel F, Langouët S, Kramer H, Le Ferrec E, Ketterer B and Guillouzo A: Inhibition of cytochrome P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res 57: 3649-3652, 1997.
16. Dick RA and Kensler TW: Chemoprotective potential of phase 2 enzyme inducers. Expert Rev Anticancer Ther 2: 581-592, 2002.
17. Xiao D, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL and Singh SV: Allyl isothiocyanate, a constituent of cruciferous vegetables inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis 24: 891-897, 2003.
18. Hu R, Kim BR, Chen C, Hebbar C and Kong AN: The role of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cell. Carcinogenesis 24: 1361-1367, 2003.
19. Srivastava SK and Singh SV: Cell cycle arrest and apoptosis-induced by benzyl isothiocyanate are associated with inhibition of nuclear factor kappa B activation in human pancreatic cancer cells. Carcinogenesis 25: 1701-1709, 2004.
20. Tang L and Zhang Y: Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J Nutr 134: 2004-2010, 2004.
21. Tseng E, Scott-Ramsay EA and Morris ME: Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood) 229: 835-842, 2004.
22. Wang LG, Liu XM and Chiao JW: Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Carcinogenesis 27: 2124-2132, 2006.
23. Preisler-Mashek MT, Solodin N, Stark BL, Tyriver MK and Alarid ET: Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha. Am J Physiol Endocrinol Metab 282: E891-E898, 2002.
24. Nicholson RI, Gee JM, Manning DL, Wakeling AE, Montano MM and Katzenellenbogen BS: Responses to pure antiestrogens (ICI 164384, ICI 182780) in estrogen-sensitive and -resistant experimental and clinical breast cancer. Ann NY Acad Sci 761: 148-163, 1995.
25. Khan SA, Rogers MA, Obando JA and Tamsen A: Estrogen receptor expression of benign breast epithelium and its association with breast cancer. Cancer Res 54: 993-997, 1994.
26. Khan SA, Rogers MA, Khurana KK, Meguid MM and Numann PJ: Estrogen receptor expression in benign breast epithelium and breast cancer risk. J Natl Cancer Inst 90: 37-42, 1998.
27. Allegra JC, Lippman ME, Green L, Barlock A, Simon R, Thompson EB, Huff KK and Griffin W: Estrogen receptor values in patients with benign breast disease. Cancer 44: 228-231, 1979.
28. Van Agthoven T, Timmermans M, Dorssers LC and Henzen-Logmans SC: Expression of estrogen, progersterone and epidermal growth factor receptors in primary and metastatic breast cancer. Int J Cancer 63: 790-793, 1995.
29. Fawell SE, White R, Hoare S, Sydenham M, Page M and Parker MG: Inhibition of estrogen receptor-DNA binding by the 'pure ' antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci USA 87: 6883-6887, 1990.
30. Dauvois S, White R and Parker MG: The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106: 1377-1388, 1993.
31. De Graffenried LA, Hopp TA, Valente AJ, Clark RA and Fuqua SA: Regulation of the estrogen receptor alpha minimal promoter by Sp1, USF-1 and ER alpha. Breast Cancer Res Treat 85: 111-120, 2004.
32. Nilsson S, Mäkelä S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M and Gustafsson JA: Mechanisms of estrogen action. Physiol Rev 81: 1535-1565, 2001.
33. Ji Y and Morris ME: Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Anal Biochem 323: 39-47, 2003.
34. Liebes L, Conaway CC, Hochster H, Mendoza S, Hecht SS, Crowell J and Chung FL: High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Anal Biochem 291: 279-289, 2001.
35. Ji Y, Kuo Y and Morris ME: Pharmacokinetics of dietary phenethyl isothiocyanate in rats. Pharm Res 22: 1658-1666, 2005.
36. Chen YR, Han J, Kori R, Kong AN and Tan TH: Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J Biol Chem 277: 39334-39342, 2002.