Telomerase reverse transcriptase (TERT) expression in canine mammary tissues: a specific marker for malignancy?

Anticancer Research

Volumn 29, Issue 1, 2009, Pages 319-325

  Zavlaris, Michael ^a   Angelopoulou, Katerina ^a   Vlemmas, Ioannis ^a   Papaioannou, Nikolaos ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Dog; Immunohistochemistry; Mammary tissue; RT PCR; Telomerase; TERT

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE; TUMOR MARKER;

ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNODETECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DOG DISEASES; DOGS; FEMALE; IMMUNOHISTOCHEMISTRY; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TELOMERASE;

EID: 61449218099     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Blackburn EH: Structure and function of telomeres. Nature 350: 569-573, 1991.
2. Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
3. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK and Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868, 1990.
4. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791, 1997.
5. Meyerson M, Counter CM, Eaton EM, Ellisen LW, Steiner P, Caddie SD et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90: 785-795, 1997.
6. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959, 1997.
7. Avilion AA, Piatyszek MA, Gupta J, Shay JW, Bacchetti S and Greider CW: Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 56: 645-650, 1996.
8. Poole JC, Andrews LG and Tollefsbol TO: Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 269: 1-12, 2001.
9. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
10. Hiyama E and Hiyama K: Telomerase as tumor marker. Cancer Lett 194: 221-233, 2003.
11. Ulaner GA: Telomerase as tumor marker. Am J Med 117: 262-269, 2004.
12. Nasir L, Devlin P, McKevitt T, Rutteman G and Argyle DJ: Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. Neoplasia 3: 351-359, 2001.
13. Argyle DJ and Nasir L: Telomerase: a potential diagnostic and therapeutic tool in canine oncology. Vet Pathol 40: 1-7, 2003.
14. Yazawa M, Okuda M, Setoguchi A, Nishimura R, Sasaki N, Hasegawa A et al: Measurement of telomerase activity in dog tumors. J Vet Med Sci 61: 1125-1129, 1999.
15. Funakoshi Y, Nakayama H, Uetsuka K, Nishimura R, Sasaki N and Doi K: Cellular proliferative and telomerase activity in canine mammary gland tumors. Vet Pathol 37: 177-183, 2000.
16. Yazawa M, Okuda M, Setoguchi A, Iwabuchi S, Nishimura R, Sasaki N et al: Telomere length and telomerase activity in canine mammary gland tumors. Am J Vet Res 62: 1539-1543, 2001.
17. Nasir L: Telomeres and telomerase: biological and clinical importance in dogs. Vet J 175: 155-163, 2008.
18. Nasir L, Gault E, Campbell S, Veeramalai M, Gilbert D, McFarlane R et al: Isolation and expression of the reverse transcriptase component of the Cani's familiaris telomerase ribonucleoprotein (dogTERT). Gene 336: 105-113, 2004.
19. Renwick MG, Argyle DJ, Long S, Nixon C, Gault EA and Nasir L: Telomerase activity and telomerase reverse transcriptase catalytic subunit expression in canine lymphoma: correlation with Ki-67 immunoreactivity. Vet Comp Oncol 4: 141-150, 2006.
20. Long S, Argyle DJ, Nixon C, Nicholson I, Botteron C, Olby N et al: Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumors. Neuropathol Appl Neurobiol 32: 662-673, 2006.
21. Panarese S, Brunetti B and Sarli G: Evaluation of telomerase in canine mammary tissues by immunohistochemical analysis and a polymerase chain reaction-based enzyme-linked immunosorbent assay. J Vet Diagn Invest 18: 362-368, 2006.
22. Colitz CM, Barden CA, Lu P and Chandler HL: Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells. Mol Vis 12: 1067-1076, 2006.
23. Mandrioli L, Panarese S, Cesari A, Mandara MT, Marcato PS and Bettini G: Immunohistochemical expression of h-telomerase reverse transcriptase in canine and feline meningiomas. J Vet Sci 8: 111-115, 2007.
24. Zarfoss MK, Klauss G, Newkirk M, Kiupel M, Jones Y, Colitz CMH et al: Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study. Vet Pathol 44: 276-284, 2007.
25. Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyl I et al: Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sc 19: 2797-2806, 2006.
26. Khurts S, Masutomi K, Delgermaa L, Aral K, Oishi N, Mizuno H et al: Nucleolin interacts with telomerase. J Biol Chem 279: 51508-51515, 2004.
27. Misdorp W: Tumors of the mammary gland. In: Tumors in Domestic Animals. Meuten DJ (ed.). Iowa, Iowa State Press, Blackwell Publishing Company, pp. 575-606 and 764, 2002.
28. Quinnell RJ, Courtenay O, Shaw MA, Day MJ, Garcez LM, Dye C et al: Tissue cytokine responses in canine visceral leishmaniasis. J Infect Dis 183: 1421-1424, 2001.
29. Ishikawa F, Matunis MJ, Dreyfuss G and Cech TR: Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol 13: 4301-4310, 1993.
30. Pollice A, Zibella MP, Bilaud T, Laroche T, Pulitzer JF and Gilson E: In vitro binding of nucleolin to double-stranded telomeric DNA. Biochem Biophys Res Commun 268: 909-915, 2000.
31. Fu W, Killen M, Culmsee C, Dhar S, Pandita TK and Mattson MP: The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J Mol Neurosci 14: 3-15, 2000.
32. Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K et al: Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J 19: 2652-2661, 2000.
33. Akiyama M, Hideshima T, Hayashi T, Tai YT, Mitsiades CS, Mitsiades N et al: Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res 63: 18-21, 2003.
34. Jagadeesh S, Kyo S and Banerjee PP: Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res 66: 2107-2115, 2006.
35. Liu K, Hodes RJ and Weng NP: Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol 166: 4826-4830, 2001.
36. Liu J, Baykal A, Fung KM, Thompson-Lanza JA, Hoque A, Lippman SM et al: Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ. Int J Oncol 24: 879-884, 2004.
37. Hines WC, Fajardo AM, Joste NE, Bisoffi M and Griffith JK: Quantitative and spatial measurements of telomerase reverse transcriptase expression within normal and malignant human breast tissues. Mol Cancer Res 3: 503-509, 2005.