Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 794, Issue 2, 2003, Pages 257-271

  Vassallo, Jeffrey D ^a   Morrall, Stephen W ^a   Fliter, Kristi L ^a   Curry, Sandra M ^a   Daston, George P ^a   Lehman McKeeman, Lois D ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Coumarin; Glutathione

Indexed keywords

ACETIC ACID; DETOXIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TOXICITY;

BIOTRANSFORMATIONS;

BIOMEDICAL ENGINEERING;

2 HYDROXYPHENYLACETALDEHYDE; 2 HYDROXYPHENYLACETIC ACID; 2 HYDROXYPHENYLETHANOL; COUMARIN 3,4 EPOXIDE; COUMARIN DERIVATIVE; EPOXIDE; GLUTATHIONE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOTRANSFORMATION; CARCINOGENICITY; CELLULAR DISTRIBUTION; CONJUGATE; CONTROLLED STUDY; EPOXIDATION; FEMALE; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER TOXICITY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE;

EID: 0041828518     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00473-2     Document Type: Article

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