A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine

Tetrahedron Letters

Volumn 41, Issue 25, 2000, Pages 4861-4864

  Zhu, Xiaoxiang ^a   Greig, Nigel H ^a   Holloway, Harold W ^a   Whittaker, Noel F ^b   Brossi, Arnold ^c   Yu, Qian Sheng ^a  

^a Drug Design and Development Section   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Alzheimer's disease therapeutic; Anticholinesterase; Butyrylcholinesterase; N1,N8 bisnorcymserine; Physostigmine

Indexed keywords

CHOLINESTERASE INHIBITOR; N1,N8 BISNORCYMSERINE; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; OXIDATION; REACTION ANALYSIS;

EID: 0034686321     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00740-1     Document Type: Article

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15. +), found: 278.1421.
16. +), found: 280.1578.
17. 2Ph), 4.92 (s, 2/3H, H-8a), 5.34 (s, 1/3H, H-8a), 6.61-6.71 (m, 2H), 8.20 (s, 2/3H, N-CHO), 8.89 (s, 1/3H, N-CHO).
18. +), found: 441.2418. Fumarate of compound 9: white crystal, mp 137-139°C.