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Volumn 3, Issue 1, 2009, Pages 49-57

BHUx: A patented polyherbal formulation to prevent hyperlipidemia and atherosclerosis

Author keywords

Anti inflammatory; Atherosclerosis; BHUx; EKO mice; Endothelial dysfunction; Food supplement; Herbal; Hyperlipidemia; M CSF; Vulnerable plaque

Indexed keywords

BHUX FORMULATION; BOSWELLIA SERRATA EXTRACT; CALCIUM ION; COLONY STIMULATING FACTOR 1; COMMIPHORA EXTRACT; FARNESOID X RECEPTOR; HERBACEOUS AGENT; NITRIC OXIDE; PLANT EXTRACT; SEMECARPUS ANACARDIUM EXTRACT; STRYCHNOX NOX VOMICA EXTRACT; TERMENALIA ARJUNA EXTRACT; UNCLASSIFIED DRUG; BHUX POLYHERBAL FORMULATION;

EID: 61449113211     PISSN: 1872213X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221309787158443     Document Type: Review
Times cited : (11)

References (70)
  • 1
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362: 801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 2
    • 70350248280 scopus 로고    scopus 로고
    • US20060147555, 2006
    • Tripathi, Y. B.: US20060147555 ((2006)).
    • Tripathi, Y.B.1
  • 4
    • 36048984001 scopus 로고    scopus 로고
    • Brewer HB Jr. HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease. Curr Cardiol Rep2007; 9(6): 486-492.
    • Brewer HB Jr. HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease. Curr Cardiol Rep2007; 9(6): 486-492.
  • 5
    • 50449086027 scopus 로고    scopus 로고
    • Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats
    • Chung DW, Kim WD, Noh SK, Dong MS. Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats. J Agric Food Chem 2008; 56(15): 6665-6670.
    • (2008) J Agric Food Chem , vol.56 , Issue.15 , pp. 6665-6670
    • Chung, D.W.1    Kim, W.D.2    Noh, S.K.3    Dong, M.S.4
  • 6
    • 0028925078 scopus 로고
    • Atherosclerosis: Basic mechanisms, oxidation, inflammation, and genetics
    • Berliner, JA, Navab M, Fogelman AM, et al. Atherosclerosis: Basic mechanisms, oxidation, inflammation, and genetics. Circulation 1995; 91: 2488-2496.
    • (1995) Circulation , vol.91 , pp. 2488-2496
    • Berliner, J.A.1    Navab, M.2    Fogelman, A.M.3
  • 7
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 8
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-1695.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 9
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R. Atherosclerosis: An inflammatory disease. N Engl J Med 1999; 340: 115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 11
    • 26244450391 scopus 로고    scopus 로고
    • Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells
    • Ge J, Jia Q, Liang C, et al. Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells. Arterioscler Thromb Vasc Biol 2005; (10): 2157-2163.
    • (2005) Arterioscler Thromb Vasc Biol , vol.10 , pp. 2157-2163
    • Ge, J.1    Jia, Q.2    Liang, C.3
  • 12
    • 50249150949 scopus 로고    scopus 로고
    • Endothelial function and inflammation in coronary artery disease
    • Tousoulis D, Charakida M, Stefanadis C. Endothelial function and inflammation in coronary artery disease. Postgrad Med J 2008; 84(993): 368-371.
    • (2008) Postgrad Med J , vol.84 , Issue.993 , pp. 368-371
    • Tousoulis, D.1    Charakida, M.2    Stefanadis, C.3
  • 13
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • 21-23
    • Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415; (21-23).
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1    Kurihara, H.2    Kimura, S.3
  • 14
    • 0029096946 scopus 로고
    • Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL: Involvement of nuclear factor kB
    • Rajavashisth TB, Yamada H, Mishra NK. Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL: involvement of nuclear factor kB. Arterioscler Thromb Vasc Biol 1995; 15: 1591-1598.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1591-1598
    • Rajavashisth, T.B.1    Yamada, H.2    Mishra, N.K.3
  • 15
    • 32944477913 scopus 로고    scopus 로고
    • Vascular nitric oxide and oxidative stress: Determinants of endothelial adaptations to cardiovascular disease and to physical activity
    • Rush JW, Denniss SG, Graham DA. Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity. Can J Appl Physiol 2005; 30(4): 442-474.
    • (2005) Can J Appl Physiol , vol.30 , Issue.4 , pp. 442-474
    • Rush, J.W.1    Denniss, S.G.2    Graham, D.A.3
  • 16
    • 22544475022 scopus 로고    scopus 로고
    • Antioxidants and endothelium protection
    • Pratico D. Antioxidants and endothelium protection. Atherosclerosis 2005; 181(2): 215-224.
    • (2005) Atherosclerosis , vol.181 , Issue.2 , pp. 215-224
    • Pratico, D.1
  • 17
    • 0023681769 scopus 로고
    • Induction of monocyte migration by recombinant macrophagecolony stimulating factor
    • Wang JM, Griffin JD, Rambaldi A, Chen ZG. Mantovani AI. Induction of monocyte migration by recombinant macrophagecolony stimulating factor. J Immunol 1988; 141: 575-579.
    • (1988) J Immunol , vol.141 , pp. 575-579
    • Wang, J.M.1    Griffin, J.D.2    Rambaldi, A.3    Chen, Z.G.4    Mantovani, A.I.5
  • 18
    • 0029096946 scopus 로고
    • Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL: Involvement of nuclear factor kB
    • Rajavashisth TB, Yamada H, Mishra NK. Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL: involvement of nuclear factor kB. Arterioscler Thromb Vasc Biol 1995; 15: 1591-1598.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1591-1598
    • Rajavashisth, T.B.1    Yamada, H.2    Mishra, N.K.3
  • 19
    • 0034570598 scopus 로고    scopus 로고
    • Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation
    • Biwa T, Sakai M, Shichiri M, Horiuchi S. Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation. J Atheroscler Thromb 2000; 7(1): 14-20.
    • (2000) J Atheroscler Thromb , vol.7 , Issue.1 , pp. 14-20
    • Biwa, T.1    Sakai, M.2    Shichiri, M.3    Horiuchi, S.4
  • 20
    • 49349089984 scopus 로고    scopus 로고
    • Frequency and predictor of coronary thin-cap fibroatheroma in patients with acute myocardial infarction and stable angina pectoris a 3-vessel optical coherence tomography study
    • Fujii K, Masutani M, Okumura T, et al. Frequency and predictor of coronary thin-cap fibroatheroma in patients with acute myocardial infarction and stable angina pectoris a 3-vessel optical coherence tomography study. J Am Coll Cardiol 2008; 52(9): 787-788.
    • (2008) J Am Coll Cardiol , vol.52 , Issue.9 , pp. 787-788
    • Fujii, K.1    Masutani, M.2    Okumura, T.3
  • 21
    • 3042733616 scopus 로고    scopus 로고
    • Vascular smooth muscle cells and calcification in ather-sclerosis
    • Trion A, van der Laarse A. Vascular smooth muscle cells and calcification in ather-sclerosis. Am Heart J 2004; 147: 808-814.
    • (2004) Am Heart J , vol.147 , pp. 808-814
    • Trion, A.1    van der Laarse, A.2
  • 22
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis ZS, Sukhova GK, Lark MW. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94: 2493-2503.
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3
  • 23
    • 0033524663 scopus 로고    scopus 로고
    • Wada T, McKee MD, Steitz S, Giachelli CM. Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin. Circ Res1999; 84: 166 -178.
    • Wada T, McKee MD, Steitz S, Giachelli CM. Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin. Circ Res1999; 84: 166 -178.
  • 24
    • 16544379772 scopus 로고    scopus 로고
    • Calcium channel blockers and atherosclerosis
    • Hirata K, Yokoyama M. Calcium channel blockers and atherosclerosis. Clin Calcium 2004; 14(1): 128-132.
    • (2004) Clin Calcium , vol.14 , Issue.1 , pp. 128-132
    • Hirata, K.1    Yokoyama, M.2
  • 25
    • 34547597709 scopus 로고    scopus 로고
    • PPARα in atherosclerosis and inflammation
    • Fokko Z, Jorge P. PPARα in atherosclerosis and inflammation. Biochim Biophys Acta 2007; 1771(8): 972-982.
    • (2007) Biochim Biophys Acta , vol.1771 , Issue.8 , pp. 972-982
    • Fokko, Z.1    Jorge, P.2
  • 26
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev 1999; 20: 649-688.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 28
    • 46349090011 scopus 로고    scopus 로고
    • Berk BC. Novel approaches to treat oxidative stress and cardiovascular diseases.Trans Am Clin Climatol Assoc 2007; 118: 209-214.
    • Berk BC. Novel approaches to treat oxidative stress and cardiovascular diseases.Trans Am Clin Climatol Assoc 2007; 118: 209-214.
  • 29
    • 0037047092 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition and cardiovascular events
    • Pitt B, Pepine C, Willerson JT. Cyclooxygenase-2 inhibition and cardiovascular events. Circulation 2002; 106, 167-169.
    • (2002) Circulation , vol.106 , pp. 167-169
    • Pitt, B.1    Pepine, C.2    Willerson, J.T.3
  • 30
    • 8244253670 scopus 로고    scopus 로고
    • Attenuation of dietinduced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties
    • Sendobry SM, Cornicelli JA, Welch K, et al. Attenuation of dietinduced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 1997; 120, 1199-1206.
    • (1997) Br J Pharmacol , vol.120 , pp. 1199-1206
    • Sendobry, S.M.1    Cornicelli, J.A.2    Welch, K.3
  • 33
    • 57349162139 scopus 로고    scopus 로고
    • Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters
    • Gastrointest Liver Physiol, Epub ahead of print
    • Valasek MA, Repa JJ, Quan G, Dietschy JM, Turley SD. Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters., Am J Physiol Gastrointest Liver Physiol 2008; [Epub ahead of print].
    • (2008) Am J Physiol
    • Valasek, M.A.1    Repa, J.J.2    Quan, G.3    Dietschy, J.M.4    Turley, S.D.5
  • 34
    • 53049092135 scopus 로고    scopus 로고
    • A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults
    • Grudell AB, Sweetser S, Camilleri M, et al. A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults. Gastroenterology 2008; 135(4): 1142-54.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1142-1154
    • Grudell, A.B.1    Sweetser, S.2    Camilleri, M.3
  • 35
    • 44049087524 scopus 로고    scopus 로고
    • Orlistat in the prevention of diabetes in the obese patient
    • Mancini MC, Halpern A. Orlistat in the prevention of diabetes in the obese patient. Vasc Health Risk Manag 2008; 4(2): 325-336.
    • (2008) Vasc Health Risk Manag , vol.4 , Issue.2 , pp. 325-336
    • Mancini, M.C.1    Halpern, A.2
  • 36
    • 33847660541 scopus 로고    scopus 로고
    • Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers
    • Joyce BM, Glaser PE, Gerhardt GA. Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Psychopharmacology 2007; 191(3): 669-677.
    • (2007) Psychopharmacology , vol.191 , Issue.3 , pp. 669-677
    • Joyce, B.M.1    Glaser, P.E.2    Gerhardt, G.A.3
  • 38
    • 70350242090 scopus 로고    scopus 로고
    • Huang, B., Chen, N., Blair, E.D.: WO2008007063 (2008).
    • Huang, B., Chen, N., Blair, E.D.: WO2008007063 (2008).
  • 39
    • 70350216436 scopus 로고    scopus 로고
    • Brink, W.D.: WO01005356 (2001).
    • Brink, W.D.: WO01005356 (2001).
  • 40
    • 70350233688 scopus 로고    scopus 로고
    • Milburn, M., Milne, J., Auwerx, J., Argmann, C., Lagouge, M., Dipp, M.: WO2007008548 (2007).
    • Milburn, M., Milne, J., Auwerx, J., Argmann, C., Lagouge, M., Dipp, M.: WO2007008548 (2007).
  • 41
    • 70350227467 scopus 로고    scopus 로고
    • Heuer, M.A.,Chaudhuri, S.,Clement, K.: WO2008067639 (2008).
    • Heuer, M.A.,Chaudhuri, S.,Clement, K.: WO2008067639 (2008).
  • 42
    • 70350216435 scopus 로고    scopus 로고
    • Uday, S., Sivaram, P., Ish, K.: WO2007143724 (2007).
    • Uday, S., Sivaram, P., Ish, K.: WO2007143724 (2007).
  • 43
    • 70350240281 scopus 로고    scopus 로고
    • Kim, S. K., Kim, S. W., Lee, S. C., Kim, W.: WO2008038973 (2008).
    • Kim, S. K., Kim, S. W., Lee, S. C., Kim, W.: WO2008038973 (2008).
  • 44
    • 70350230577 scopus 로고    scopus 로고
    • Uday, S., Sivaram, P., Ish, K.: WO2007143724A2 (2007).
    • Uday, S., Sivaram, P., Ish, K.: WO2007143724A2 (2007).
  • 45
    • 70350222612 scopus 로고    scopus 로고
    • Bukowski, J. F., Walters, J.: WO2008036807 (2008).
    • Bukowski, J. F., Walters, J.: WO2008036807 (2008).
  • 46
    • 70350240282 scopus 로고    scopus 로고
    • US20036541046
    • Wei, D.: US20036541046 (2003).
    • (2003)
    • Wei, D.1
  • 47
    • 70350232330 scopus 로고    scopus 로고
    • Morton, N., Seckl, J.R., Walker, B.R., Andrew, R.: EP1420769 (2008).
    • Morton, N., Seckl, J.R., Walker, B.R., Andrew, R.: EP1420769 (2008).
  • 48
    • 70350248276 scopus 로고    scopus 로고
    • Clement, K., Heuer, Marvin A., Thomas, M., Mason, E.: WO2008049196 ( 2008).
    • Clement, K., Heuer, Marvin A., Thomas, M., Mason, E.: WO2008049196 ( 2008).
  • 49
    • 70350227469 scopus 로고    scopus 로고
    • Clement, K., Heuer, M.A., Thomas, M., Mason, E.: WO2008049196A1 (2008).
    • Clement, K., Heuer, M.A., Thomas, M., Mason, E.: WO2008049196A1 (2008).
  • 50
    • 70350219546 scopus 로고    scopus 로고
    • Tripathi, Y. B.: WO2004062566A2 (2004).
    • Tripathi, Y. B.: WO2004062566A2 (2004).
  • 51
    • 0027272310 scopus 로고
    • Terminalia arjuna extract modulates the concentration of rat aorta induced by KCL and norepinephrine
    • Tripathi YB. Terminalia arjuna extract modulates the concentration of rat aorta induced by KCL and norepinephrine. Phytother Res 1993; 7: 320-322.
    • (1993) Phytother Res , vol.7 , pp. 320-322
    • Tripathi, Y.B.1
  • 52
    • 70350222616 scopus 로고    scopus 로고
    • Agarwal, K. C.: WO2008005275 (2008).
    • Agarwal, K. C.: WO2008005275 (2008).
  • 53
    • 0343540674 scopus 로고
    • Boswellic acids are penta cyclic triterpenic acids belonging to the class of ursane group of triterpenoids
    • Bischof B, Jerger O, Ruzicka LH. Boswellic acids are penta cyclic triterpenic acids belonging to the class of ursane group of triterpenoids. Chim Acta 1949; 32: 1911.
    • (1949) Chim Acta , vol.32 , pp. 1911
    • Bischof, B.1    Jerger, O.2    Ruzicka, L.H.3
  • 54
    • 70350216438 scopus 로고    scopus 로고
    • Majeed, M., Badmaev, V.: WO00066111A1 (2000).
    • Majeed, M., Badmaev, V.: WO00066111A1 (2000).
  • 55
    • 70350248277 scopus 로고    scopus 로고
    • Jauch, J.: WO02085921A3 (2002).
    • Jauch, J.: WO02085921A3 (2002).
  • 57
    • 70350240284 scopus 로고    scopus 로고
    • Bombardelli, E., Spelta, M.: EP0513671 (1992).
    • Bombardelli, E., Spelta, M.: EP0513671 (1992).
  • 58
    • 70350222614 scopus 로고    scopus 로고
    • McCook, John P., Corey, Joseph M., Dorogi, Peter L., Bajor, John S., Knaggs, Helen E., Lange, Beth A., Sharpe, E.: US5690948 (1997).
    • McCook, John P., Corey, Joseph M., Dorogi, Peter L., Bajor, John S., Knaggs, Helen E., Lange, Beth A., Sharpe, E.: US5690948 (1997).
  • 61
    • 70350235449 scopus 로고    scopus 로고
    • Hamied, Y.K.W.: EP0447706 A1 (1991).
    • Hamied, Y.K.W.: EP0447706 A1 (1991).
  • 62
    • 24344471669 scopus 로고    scopus 로고
    • Yamini B T, Birendra K S, Ravi S P, Mohan K. BHUx: A patent polyherbal formulation to prevent atherosclerosis. eCAM 2005; 2 (2) 217-221.
    • Yamini B T, Birendra K S, Ravi S P, Mohan K. BHUx: A patent polyherbal formulation to prevent atherosclerosis. eCAM 2005; 2 (2) 217-221.
  • 64
    • 0037205046 scopus 로고    scopus 로고
    • A natural product that lowers cholesterol as an antagonist ligand for FXR
    • Urizar NL, Liverman AB, Dodds DT, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 2002; 296, 1703-1706.
    • (2002) Science , vol.296 , pp. 1703-1706
    • Urizar, N.L.1    Liverman, A.B.2    Dodds, D.T.3
  • 65
    • 70350229182 scopus 로고    scopus 로고
    • Personal Communication
    • Tripathi Y B. Personal Communication 2008.
    • (2008)
    • Tripathi, Y.B.1
  • 66
    • 0032907637 scopus 로고    scopus 로고
    • 15-Lipoxygenase and its inhibition: A novel therapeutic target for vascular diseases
    • Cornicelli JA, Trivedi BK. 15-Lipoxygenase and its inhibition: A novel therapeutic target for vascular diseases. Curr Pharm Design 1999; 5, 11-20.
    • (1999) Curr Pharm Design , vol.5 , pp. 11-20
    • Cornicelli, J.A.1    Trivedi, B.K.2
  • 67
    • 3242657345 scopus 로고    scopus 로고
    • Anti-inflammatory properties of BHUx, a polyherbal formulation to prevent atherosclerosis
    • Tripathi YB, Reddy MM, Pandey RS, et al. Anti-inflammatory properties of BHUx, a polyherbal formulation to prevent atherosclerosis. Inflammopharmacology 2004; 12(2): 131-152.
    • (2004) Inflammopharmacology , vol.12 , Issue.2 , pp. 131-152
    • Tripathi, Y.B.1    Reddy, M.M.2    Pandey, R.S.3
  • 68
    • 0030969425 scopus 로고    scopus 로고
    • Role of macrophage colonystimulating factor in atherosclerosis: Studies of osteopetrotic mice
    • Qiao JH, Tripathi J, Mishra NK, et al. Role of macrophage colonystimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 1997; 150(5): 1687-1699.
    • (1997) Am J Pathol , vol.150 , Issue.5 , pp. 1687-1699
    • Qiao, J.H.1    Tripathi, J.2    Mishra, N.K.3
  • 70
    • 84979132832 scopus 로고
    • Bemerkungen zu der Abhandlung der HH: Wesely und Benedikt "Über einige Azoverbindungen
    • Griess JP. Bemerkungen zu der Abhandlung der HH: Wesely und Benedikt "Über einige Azoverbindungen". Ber Deutsch Chem Ges 1879; 12: 426-428.
    • (1879) Ber Deutsch Chem Ges , vol.12 , pp. 426-428
    • Griess, J.P.1


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