Anti-inflammatory properties of BHUx, a polyherbal formulation to prevent atherosclerosis

Inflammopharmacology

Volumn 12, Issue 2, 2004, Pages 131-152

  Tripathi, Yamini B ^a   Reddy, M Mallikarjuna ^b   Pandey, R S ^a   Subhashini, J ^b   Tiwari, O P ^a   Singh, B K ^a   Reddanna, P ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

Antioxidant; Atherosclerosis; Ayurveda; Cyclooxygenase; Herbal; Inflammation; Lipoxygenase; Nitric oxide

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; AYURVEDIC DRUG; BHUX; BOSWELLIA SERRATA EXTRACT; CARRAGEENAN; COMMIPHORA MUKUL EXTRACT; CUMENE HYDROPEROXIDE; CYCLOOXYGENASE 2; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; PLANT EXTRACT; SEMECARPUS ANACARDIUM EXTRACT; STRYCHNOS NUX VOMICA EXTRACT; TERMINALIA ARJUNA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; BOSWELLIA; BOSWELLIA SERRATA; COMMIPHORA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; FILTER; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LIPID PEROXIDATION; LIVER HOMOGENATE; MEDICINAL PLANT; NONHUMAN; PAW EDEMA; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; SEMECARPUS; SEMECARPUS ANACARDIUM; STRYCHNOS NUX VOMICA; TERMINALIA; TERMINALIA ARJUNA;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTERIOSCLEROSIS; BOSWELLIA; CHEMISTRY, PHARMACEUTICAL; COMMIPHORA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MEDICINE, AYURVEDIC; PHYTOTHERAPY; PLANT EXTRACTS; PLANT PREPARATIONS; RATS; SEMECARPUS; STRYCHNOS NUX-VOMICA; TERMINALIA;

EID: 3242657345     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/1568560041352301     Document Type: Article

References (91)

1. 2+ mobilization, Biochem. Biophys. Res. Commun. 290, 185-190.
2. Ammon, H. P. (2002). Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases, Wien Med. Wochenschr. 152, 373-378.
3. Arora, R. B., Kapoor, V., Gupta, S. K., et al. (1971). Isolation of a crystalline steroidal compound from Commiphora mukul and its anti-inflammatory activity, Ind. J. Exp. Biol. 9, 403-404.
4. Bailey, J. M. and Butler, J. (1973). Anti-inflammatory drugs in experimental atherosclerosis. I: relative potencies for inhibiting plaque formation, Atherosclerosis 17, 517-522.
5. Bailey, P. J. (1988). Sponge implants as models, Methods Enzymol. 162, 327-334.
6. Baser, K. H. C., Bisset, N. G. and Hylands, P. J. (1979). Protostrychnine, a new alkaloid from Strychnos nux-vomica, Phytochemistry 18, 512-514.
7. Bhagat, K. and Vallance, P. (1997). Inflammatory cytokines impair endothelium dependent dilation in human veins in vivo, Circulation 96, 3042-3047.
8. Biasucci, L. M., Liuzzo, G. and Fantuzzi, G. (1999). Increasing levels of interleukin (IL)-I Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events, Circulation 99, 2079-2084.
9. Bobbili, V. V., Parthasarathi, A., Mubarak Ali, A., et al. (2003). Phycocyanin mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS, Mol. Cancer Ther. 2, 1165-1170.
10. Bratati, D. and Dutta, P. C. (1988). Alkaloid of Strychnos mix-vomica flower, Planta Med. 54, 363.
11. Bratati, D. and Dutta, P. C. (1991). Alkaloid in floral parts of Strychnos mix-vomica, Planta Med. 57, 19-20.
12. Burleigh, M. E., Babaev, V. R., Oates, J. A., et al. (2002). Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice, Circulation 105, 1816-1823.
13. Cerletti, C., Evangelista, V. and de Gaetano, G. (1999). P-selectin-beta 2-integrin cross talk: a molecular mechanism for polymorphonumclear leukocyte recruitment at the site of vascular damage, Thromb. Haemost. 82, 787-793.
14. Chaurasia, S., Tripathi, P. and Tripathi, Y. B. (1995). Antioxidant and anti-inflammatory property of Sandhika: A compound herbal drug, Ind. J. Exp. Biol. 33, 428-432.
15. Chenevard, R., Hürlimann, D., Béchir, M., et al. (2003). Selective COX-2 inhibition improves endothelial function in coronary artery disease, Circulation 107, 405-409.
16. Chitnis, M. P., Bhatia, K. G., Pathak, M. K., et al. (1980). Anti-tumour activity of the extract of Semecarpus anacardium L. nuts in experimental tumour models, Ind. J. Exp. Biol. 18, 6-8.
17. Choudhuri, R. C. (1977). Role of some indigenous drugs in sandhigata vata, Rheumatism 13, 10-15.
18. Cornicelli, J. A. and Trivedi, B. K. (1999). 15-Lipoxygenase and its inhibition: A novel therapeutic target for vascular diseases, Curr. Pharm. Design 5, 11-20.
19. Culioli, G., Mathe, C., Archier, P., et al. (2003). A lupane triterpene from frankincense (Boswellia sp., Burseraceae), Phytochemistry 62, 537-541.
20. De Gaetano, G. (2001). Aspirin and the prevention of ischemic heart disease. A Socratic dialogue between a cardiologist, a clinical pharmacologist and an expert of blood platelets, Ital. Heart J. 2, 582-588.
21. De Gaetano, G., et al. (2002). Pharmacogenetics as a new antiplatelet strategy, in: Platelets in Thrombotic and Non Thrombotic Disorders, Gresele, P., Page, C. P., Fuster, V. and Vermylen, J. (Eds), pp. 964-977. Cambridge University Press, Cambridge.
22. Dekebo, A., Dagne, E. and Sterner, O. (2002). Furanosesquiterpenes from Commiphora sphaerocarpa and related adulterants of true myrrh, Fitoterapia 73, 48-55.
23. Ding, A. H., Nathan, C. F. and Stuehr, D. J. (1998). Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages, comparison of activating cytokines and evidence for independent production, J. Immunol. 141, 2407-2412.
24. George, J., Afek, A., Shaish, A., et al. (2001). 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice, Circulation 104, 1646-1650.
25. Gil, R. R., Lin, L., Cordell, G. A., et al. (1995). Anacardoside from the seeds of Semecarpus anacardium, Phytochemistry 39, 405-407.
26. Gothoskar, S. V. and Ranadive, K. J. (1971). Anticancer screening of SAN-AB: An extract of marking nut Semicarpus anacardium, Ind. J. Exp. Biol. 9, 372-375.
27. Grossman, S., Ben Aziz, A., Budowski, P., et al. (1968). Enzymic oxidation of carotene and linoleate by alfalfa: Extraction and separation of active reactions, Phytochemistry 8, 2287-2293.
28. Gupta, I., Parihar, A., Malhotra, P., et al. (1997). Effects of Boswellia serrata gum resin in patients with ulcerative colitis, Eur. J. Med. Res. 2, 37-43.
29. Gupta, I., Gupta, V., Parihar, A., et al. (1998). Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study, Eur. J. Med. Res. 3, 511-514.
30. Gupta, I., Parihar, A., Malhotra, P., et al. (2001). Effects of gum resin of Boswellia serrata in patients with chronic colitis, Planta Med. 67, 391-395.
31. Gupta, R., Singhal, S., et al. (2001). Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomised placebo-controlled trials, J. Ass. Phys. Ind. 49, 231-235.
32. Horowitz, R. M. and Jurd, L. (1961). Spectral studies on flavonoid compounds. II. Isoflavones and flavanones, J. Org. Chem. 26, 2446-2449.
33. Jessup, W., Mander, E. L. and Dean, R. T. (1992). The intercellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages, Biochim. Biophys. Acta 1126, 167-177.
34. Kaur, K., Arora, S., Kumar, S., et al. (2002). Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay, J. Environ. Pathol. Toxicol. Oncol. 21, 45-56.
35. Khan, M. T., Lampronti, I., Martello, D., et al. (2002). Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines, Int. J. Oncol. 21, 187-192.
36. Kharbanda, R. K., Walton, B., Allen, M., et al. (2002). Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin, Circulation 105, 2600-2604.
37. Kimmatkar, N., Thawani, V., Hingorani, L., et al. (2003). Efficasy and tolerability of Boswellia serrata extract in treatment of osteoarthitis of knee - a randomized double blind placebo controlled trial, Phytomedicine, 10, 3-7.
38. Krohn, K., Rao, M. S., Raman N. V., et al. (2001). High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb, Phytochem. Anal. 12, 374-376.
39. Lowry, O. H., Rosebrough, N. J., Farr, A. L., et al. (1951). Protein determination using folin-ciocalteau reagent, J. Biol. Chem. 193, 438-448.
40. Malone, M. H. (1992). Brucine lethality in mice, J. Ethnopharmacol. 35, 295-297.
41. Marcus, A. J., Broekman, M. J., Safier, L. B., et al. (1982). Formation of leukotrienes and other hydroxy acids during platelet neutrophil interactions in vitro, Biochem. Biophys. Res. Commun. 109, 130-137.
42. Masilamani, G., Ali, S. and Subbulakshmi, V. (1981). Study of karappan (eczema), J. Res. Ayurveda Siddha 2, 109-121.
43. Mehrabian, M. and Allayee, H. (2003). 5-lipoxygenase and atherosclerosis, Curr. Opin. Lipidol. 14, 447-457.
44. Mehrabian, M., Allayee, H., Wong, J., et al. (2002). Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice, Circ. Res. 91, 120-126.
45. Menon, M. K. and Kar, A. (1971). Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata, Planta Med. 19, 333-341.
46. Miller, A. L. (1998). Botanical influences on cardiovascular disease, Altern. Med. Rev. 3, 422-431.
47. Mukherjee, P. K., Mukherjee, K., Rajesh Kumar, M., et al. (2003). Evaluation of wound healing activity of some herbal formulations, Phytother. Res. 17, 265-268.
48. Murthy, S. S. N. (1988). Semecarpetin, a biflavanone from Semecarpus anacardium, Phytochemistry 27, 3020-3022.
49. Okhawa, H., Ohishi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric reaction, Anal. Biochem. 95, 351-358.
50. Qiao, J.-H., Tripathi, J., Mishra, N. K., et al. (1997). Role of macrophage colony-stimulating factor in atherosclerosis - studies of osteopetrotic mice, Am. J. Pathol. 150, 1678-1699.
51. Panda, P. K. and Panda, D. P. (1993). Antiulcer activity of nux vomica and its comparison with cimetidine in shay rat, Ind. Drugs 30, 53-56.
52. Pandey, G. S. and Chunekar, K. C. (1967). In: Bhavaprakash Bhavaprakash nighantu, pp. 139-141. Chaukhambha Vidya Bhawan, Varanasi.
53. Pandey, S., Sharma, M., Chaturvedi, P., et al. (1994). Protective effect of Rubia Cardifolia on lipid peroxide formation in isolated rat liver homogenate, Ind. J. Exp. Biol. 32, 180-183.
54. Paramashivappa, R., Phani Kumar, P., Subba Rao, P. V., et al. (2002). Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition, J. Agric. Food. Chem. 18, 7709-7713.
55. Park, Y. S., Lee, J. H., Harwalkar, J. A., et al. (2002). Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2, Adv. Exp. Med. Biol. 507, 387-393.
56. Pettit, G. R., Hoard, M. S., Doubek, D. L., et al. (1996). Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae), J. Ethnopharmacol. 53, 57-63.
57. Pitt, B., Pepine, C. and Willerson, J. T. (2002). Cyclooxygenase-2 inhibition and cardiovascular events, Circulation 106, 167-169.
58. Pratico, D., Tillmann, C., Zhang, Z. B., et al. (2001). Acceleration of atherogenesis by COX-1 dependent prostanoid formation in low-density lipoprotein receptor knockout mice, Proc. Natl. Acad. Sci. USA 98, 3358-3363.
59. Rao, N. S. P., Row, L. R. and Brown, R. T. (1973). Phenolic constituents of Semecarpus anacardium, Phytochemistry 12, 671-675.
60. Rauch, U., Osende, J. I., Fuster, V., et al. (2001). Thrombus formation on atherosclerotic plaques: pathogenesis and clinical consequences, Ann. Intern. Med. 134, 224-238.
61. Reddanna, P., Whelan, J., Maddipati K. R., et al. (1990). Purification of arachidonate 5-lipoxygenase from potato tubers, Methods Enzymol. 187, 268-277.
62. Reddy, C. M., Bhat, V. B., Kiranmai, G., et al. (2000). Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis, Biochem. Biophys. Res. Commun. 277, 599-603.
63. Ross, R. (1999). Atherosclerosis: an inflammatory disease, New Engl. J. Med. 340, 115-126.
64. Rucker, G. (1972). Monocyclic diterpenes from Indian gugul resin (Commiphora mukul), Arch. Pharm. 305, 486-493.
65. Satyavati, G. V., Prasad, G. V., Das, P. K., et al. (1969). Anti-inflammatory activity of Semecarpus anacardium Linn - A preliminary study, Ind. J. Physiol. Pharmacol. 13, 37-45.
66. Sendobry, S. M., Comicelli, J. A., Welch, K., et al. (1997). Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties, Br. J. Pharmacol. 120, 1199-1206.
67. Shaila, H. P., Udupa, S. L., Udupa, A. L., et al. (1998). Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis, Int. J. Cardiol. 67, 119-124.
68. Sharma, A., Mathur, R. and Dixit, V. P. (1995). Hypocholesterolemic activity of nutshell extract of Semecarpus anacardium (Bhilawa) in cholesterol fed rabbits, Ind. J. Exp. Biol. 33, 444-448.
69. Singh, L. M. and Gupta, G. (1991). Research on antiviral efficacy on homeopathic drugs against animal viruses, Homeopathic Heritage 16, 113-117.
70. Smith, W. L., Garavito, R. M. and Dewitt, D. L. (1996). Prostaglandin endoperoxide H synthases (cyclooxygenase-)-1 and -2, J. Biol. Chem. 271, 33157-33160.
71. Solomon, D. H., Karlson, E. W., Rimm, E. B., et al. (2003). Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis, Circulation 107, 1303-1307.
72. Spanbroek, R. and Habenicht, A. J. (2003). The potential role of antileukotriene drugs in atherosclerosis, Drug News Perspect. 16, 485-489.
73. Spanbroek, R., Grabner, R., Lotzer, K., et al. (2003). Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis, Proc. Natl. Acad. Sci. USA 100, 1238-1243.
74. Subhashini, J., Mahipal, S. V. K., Reddy, M. C., et al. (2004). Molecular mechanisms involved in C-phycocyanin induced apoptosis in human chronic myeloid leukemia cell line K562, Biochem. Pharmacol., in press.
75. Sumitra, M., Manikandan, P., Kumar, D. A., et al. (2001). Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status, Mol. Cell. Biochem. 224, 135-142.
76. Tripathi, Y. B. and Chaurasia, S. (1996). Effect of S. nuxvomica alcoholic extract on lipid peroxidation in rat liver, Int. J. Pharmacol. 34, 295-299.
77. Tripathi, Y. B. and Pandey, R. S. (2003). Semecarpus anacardium L. nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property, Ind. J. Exp. Biol., in press.
78. Tripathi, Y. B. and Singh, A. V. (2001). Effect of Semecarpus anacardium nuts on lipid peroxidation, Ind. J. Exp. Biol. 39, 798-801.
79. Tripathi, Y. B., Malhotra, O. P. and Tripathi, S. N. (1984). Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul, Planta Med. 1, 78-80.
80. Tripathi, Y. B., Tripathi, V. P. and Tripathi, P. (1989). Effect of T. arjuna-extract on KCl-induced contraction on rat vas deferens. Phytother. Res. 13, 162-164.
81. Tripathi, Y. B., Tripathi, P., Reddy, M. V. R., et al. (1988a). Effect of Semicarpus anacardium on cell cycle of DU-145 cells, Phytomedicine 5, 383-388.
82. Tripathi, Y. B., Tripathi, P., Malhotra, O. P., et al. (1988b). Thyroid stimulatory action of guggulsterone: mechanism of action. Planta Med. 4, 271-276.
83. Tripathi, Y. B., Sharma, M., Shukla, S., et al. (1995). Rubia cordifolia inhibits potato-lipoxygenases, Ind. J. Exp. Biol. 33, 109-112.
84. th Annual conference of Indian Society for Atherosclerosis Research, Tirupati, 2002 (abstract).
85. Urizar, N. L., Liverman, A. B., Dodds, D. T., et al. (2002). A natural product that lowers cholesterol as an antagonist ligand for FXR, Science 296, 1703-1706.
86. Vallance P., Collier J. and Bhagat, K. (1997). Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?, Lancet 349, 1391-1392.
87. Wesley, R. B., Meng, X., Godin, D., et al. (1998). Extracellular matrix modulates macrophage functions characteristic to atheroma: collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro, Arterioscler Thromb Vasc. Biol. 18, 432-440.
88. Winter, C. A., Risley, E. A. and Nuss, G. W. (1962). Carragenan induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med. 111, 544-547.
89. Yamamoto, S. (1991). "Enzymatic" lipid peroxidation: Reactions of mammalian lipoxygenases, Free Radic. Biol. Med. 10, 149-159.
90. Zhu, H., Takahashi, Y., Xu, W., et al. (2003). Low density lipoprotein receptor-related protein-mediated membrane translocation of 12/15-lipoxygenase is required for oxidation of low density lipoprotein by macrophages, J. Biol. Chem. 278, 13350-13355.
91. Zschocke, S. and Van Staned, J. (2000). Cryptocarya species substitute plants for Ocotea bullata? A pharmacological investigation in terms of cyclooxygenase-1 and -2 inhibition, J. Ethnopharmacol. 71, 473-478.