N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1745-1748

  Barf, Tjeerd ^a   Lehmann, Fredrik ^a   Hammer, Kristin ^a   Haile, Saba ^a   Axen, Eva ^a   Medina, Carmen ^a   Uppenberg, Jonas ^a   Svensson, Stefan ^a   Rondahl, Lena ^a   Lundbäck, Thomas ^a  

^a BIOVITRUM AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; FATTY ACID BINDING PROTEIN 4; N BENZYL HEXAHYDROCYCLOHEPTA[B]INDOLE; N BENZYL INDOLO CARBOXYLIC ACID DERIVATIVE; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; HUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ADIPOCYTES; ANIMALS; BINDING SITES; CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FATTY ACID-BINDING PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; SPECTROMETRY, FLUORESCENCE;

EID: 61349199697     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.084     Document Type: Article

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