Roles of protein kinase Cα isozyme in the regulation of oxidative stress and neuropeptide y gene expression in phenylpropanolamine-mediated appetite suppression

Journal of Neurochemistry

Volumn 108, Issue 6, 2009, Pages 1495-1506

  Kuo, Dong Yih ^a   Yang, Shun Fa ^a   Chu, Shu Chen ^b   Chen, Chin Hsiu ^a   Hsieh, Yih Shou ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Appetite suppression; Brain; Neuropeptide Y; Oxidative stress; Protein kinase C

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; NEUROPEPTIDE Y; PHENYLPROPANOLAMINE; PROOPIOMELANOCORTIN; PROTEIN KINASE C ALPHA; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; GENE EXPRESSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; APPETITE; APPETITE DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; GENE EXPRESSION REGULATION; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; ISOENZYMES; MALE; NEUROPEPTIDE Y; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OXIDATIVE STRESS; PHENYLPROPANOLAMINE; PROTEIN KINASE C-ALPHA; RATS; RATS, WISTAR; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 61349175883     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05909.x     Document Type: Article

References (55)

1. Alexander M., Rothman R. B., Baumann M. H., Endres C. J., Brasic J. R. Wong D. F. (2005) Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis. Synapse 56, 94 99.
2. Balbi D. Allen J. M. (1994) Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells. Brain Res. Mol. Brain Res. 23, 310 316.
3. Banday A. A., Fazili F. R. Lokhandwala M. F. (2007) Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C. J. Am. Soc. Nephrol. 18, 1446 1457.
4. Battaini F. (2001) Protein kinase C isoforms as therapeutic targets in nervous system disease states. Pharmacol. Res. 44, 353 361.
5. Benavides M., Laorden M. L., Marin M. T. Milanes M. V. (2005) Role of PKC-alpha,gamma isoforms in regulation of c-Fos and TH expression after naloxone-induced morphine withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups. J. Neurochem. 95, 1249 1258.
6. Cao G., Gardner A. Westfall T. C. (2007) Mechanism of dopamine mediated inhibition of neuropeptide Y release from pheochromocytoma cells (PC12 cells). Biochem. Pharmacol. 73, 1446 1454.
7. Cheng J. T. Kuo D. Y. (2003) Both α1-adrenergic and D1-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice. Neurosci. Lett. 347, 136 138.
8. Chomczynski P. Sacchi N. (1987) Single-step method of RNA isolation by acid quanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156 159.
9. Colman E. (2005) Anorectics on trial: a half century of federal regulation of prescription appetite suppressants. Ann. Intern. Med. 143, 380 385.
10. Corbit K. C., Soh J. W., Yoshida K., Eves E. M., Weinstein I. B. Rosner M. R. (2000) Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol. Cell. Biol. 20, 5392 5403.
11. Crowley W. R., Ramoz G., Keefe K. A., Torto R., Kalra S. P. Hanson G. R. (2005) Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats. Neuroscience 132, 167 173.
12. Dean N. M. McKay R. (1994) Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl Acad. Sci. USA 91, 11762 11766.
13. 2+/calmodulin-dependent protein kinase II. Am. J. Physiol-Regul. Integr. Comp. Physiol. 285, R632 R640.
14. Frazier D. P., Wilson A., Dougherty C. J., Li H., Bishopric N. H. Webster K. A. (2007) PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. Am. J. Physiol-Heart Circ. Physiol. 292, H1675 H1684.
15. Fujita T., Ikuta J., Hamada J., Okajima T., Tatematsu K., Tanizawa K. Kuroda S. (2004) Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem. Biophys. Res. Commun. 313, 738 744.
16. Ghosh M. K., Ghosh K., Dahl O. Cohen J. S. (1993) Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application. Nucleic Acids Res. 21, 5761 5766.
17. Giambalvo C. T. (2004) Mechanisms underlying the effects of amphetamine on particulate PKC activity. Synapse 51, 128 139.
18. Goodhue A., Bartel R. L. Smith N. B. (2000) Exacerbation of psychosis by phenylpropanolamine. Am. J. Psychiatry 157, 1021 1022.
19. Hsieh Y. S., Yang S. F., Chiou H. L. Kuo D. Y. (2005) Transcriptional involvement of protein kinase C-alpha isozyme in amphetamine-mediated appetite suppression. Eur. J. Neurosci. 22, 715 723.
20. Hsieh Y. S., Yang S. F., Chiou H. L. Kuo D. Y. (2006) Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Toxicol. Appl. Pharm. 212, 99 109.
21. Hsieh Y. S., Yang S. F. Kuo D. Y. (2007a) Transcript of protein kinase A knock down modulates feeding behavior and neuropeptide Y gene expression in phenylpropanolamine-treated rats. Physiol. Genomics 31, 306 314.
22. Hsieh Y. S., Yang S. F., Chiou H. L. Kuo D. Y. (2007b) Roles of central catecholamine and hypothalamic neuropeptide Y genome in the development of tolerance to phenylpropanolamine-mediated appetite suppression. Behav. Neurosci. 121, 933 940.
23. Hsieh Y. S., Yang S. F., Chu S. C. Kuo D. Y. (2008a) Interrupting activator protein-1 signaling in conscious rats can modify neuropeptide Y gene expression and feeding behavior of phenylpropanolamine. J. Neurochem. 104, 50 61.
24. Hsieh Y. S., Yang S. F., Chu S. C., Ho Y. J., Kuo C. S. Kuo D. Y. (2008b) Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. J. Neurochem. 105, 1438 1449.
25. Hua X. Y., Moore A., Malkmus S., Murray S. F., Dean N., Yaksh T. L. Butler M. (2002) Inhibition of spinal protein kinase C alpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance. Neuroscience 113, 99 107.
26. Johnson L. A., Guptaroy B., Lund D., Shamban S. Gnegy M. E. (2005) Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. J. Biol. Chem. 280, 10914 10919.
27. Kaneki M., Kharbanda S., Pandey P., Yoshida K., Takekawa M., Liou J. R., Stone R. Kufe D. (1999) Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol. Cell. Biol. 19, 461 470.
28. Kanoh Y., Sajan M. P., Bandyopadhyay G., Miura A., Standaert M. L. Farese R. V. (2003) Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes. Endocrinology 144, 947 954.
29. Kim E. H., Shin M. S., Chang H. K., Lee T. H., Jang M. H., Shin M. C., Lee S. J. Kim C. J. (2004) Aqueous extract of ma huang suppresses neuropeptide Y expression in food-deprived rat hypothalamus. Am. J. Chin. Med. 32, 659 667.
30. Kitazawa M., Anantharam V. Kanthasamy A. G. (2003) Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 119, 945 964.
31. Kolár F., Jezková J., Balková P. et al. (2007) Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia. Am. J. Physiol-Heart Circ. Physiol. 292, H224 H230.
32. Levin O. S. (2005) "Ephedron" encephalopathy. Zh Nevrol Psikhiatr Im S S Korsakova. (Russia) 105, 12 20.
33. Magni P., Maggi R., Pimpinelli F. Motta M. (1998) Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells. Brain Res. 798, 75 82.
34. Morris B. J. (1989) Neuronal localization of neuropeptide Y gene expression in rat brain. J. Comp. Neurol. 290, 358 368.
35. Nishizuka Y. (1988) The molecular heterogeneity of protein kinase C and its implication for cellular recognition. Nature 334, 661 665.
36. Ogawa S. Pfaff D. W. (1998) Current status of antisense DNA methods in behavioral studies. Chem. Senses 23, 249 255.
37. Paxinos G. Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. 2nd edn. Academic Press, Sydney, Australia.
38. Pilsczek F. H., Karcic A. A. Freeman I. (2003) Case report: dexatrim (phenylpropanolamine) as a cause of myocardial infarction. Heart Lung 32, 100 104.
39. Ridge K. M., Dada L., Lecuona E., Bertorello A. M., Katz A. I., Mochly-Rosen D. Sznajder J. I. (2002) Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta. Mol. Biol. Cell 13, 1381 1389.
40. Ritter R. C., Slusser P. G. Stone S. (1981) Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213, 451 452.
41. Roseberry A. G., Liu H., Jackson A. C., Cai X. Friedman J. M. (2004) Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41, 711 722.
42. Stier B. G. Hennekens C. H. (2006) Phenylpropanolamine and hemorrhagic stroke in the Hemorrhagic Stroke Project: a reappraisal in the context of science, the Food and Drug Administration, and the law. Ann. Epidemiol. 16, 49 52.
43. Szumlinski K. K., Liu A., Penzner J. H. Lominac K. D. (2007) Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine. Neuropsychopharmacology 32, 1760 1773.
44. Toll K. Graf P. (2006) Phenylpropanolamine's decongestive effect on the nasal mucosa of pregnant women with nasal stuffiness. Rhinology 44, 274 277.
45. Troller U., Zeidman R., Svensson K. Larsson C. (2001) A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells. FEBS Lett. 508, 126 130.
46. Valassi E., Scacchi M. Cavagnini F. (2008) Neuroendocrine control of food intake. Nutr. Metab. Cardiovasc. Dis. 18, 158 168.
47. Way K. J., Chou E. King G. L. (2000) Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol. Sci. 21, 181 187.
48. Wellman P. J. Davies B. T. (1992) Reversal of cirazoline- and phenylpropanolamine-induced anorexia by the α1-adrenergic receptor antagonist prazosin. Pharmacol. Biochem. Behav. 42, 97 100.
49. Widnell K. L., Self D. W., Lane S. B., Russell D. S., Vaidya V., Miserendino M. J. D., Rubin C. S., Duman R. S. Nestler E. J. (1996) Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J. Pharmacol. Exp.Ther. 276, 306 315.
50. Williams G., Bing C., Cai X. J., Harrold J. A., King P. J. Liu X. H. (2000) The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol. Behav. 74, 683 701.
51. Wynne K., Stanley S., McGowan B. Bloom S. (2005) Appetite control. J. Endocrinol. 184, 291 318.
52. Yun J. Y., Park K. S., Kim J. H., Do S. H. Zuo Z. (2007) Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement. Eur. J. Pharmacol. 565, 83 88.
53. Zaloga G. P., Clark J. D. Roberts P. R. (2000) Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine. Crit. Care Med. 28, 3679 3683.
54. Zhang M. Creese I. (1993) Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: behavioral correlates. Neurosci. Lett. 161, 223 226.
55. Zhang D., Kanthasamy A., Yang Y., Anantharam V. Kanthasamy A. (2007) Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J. Neurosci. 27, 5349 5362.