Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

American Journal of Chinese Medicine

Volumn 32, Issue 5, 2004, Pages 659-667

  Kim, Ee Hwa ^a   Shin, Mal Soon ^b   Chang, Hyun Kyung ^b   Lee, Taeck Hyun ^b   Jang, Mi Hyeon ^b   Shin, Min Chul ^b   Lee, Sam Jun ^b   Kim, Chang Ju ^b  

^a Semyung University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Hypothalamus; Immunohistochemistry; Ma huang; Neuropeptide Y

Indexed keywords

ALKALOID; EPHEDRA SINICA EXTRACT; EPHEDRINE; NEUROPEPTIDE Y; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EPHEDRA SINICA; FOOD DEPRIVATION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; EPHEDRA SINICA; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 21744458810     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X04002326     Document Type: Article

References (32)

1. Astrup, A., L. Breum and S. Toubro. Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes. Res. 3: 537S-540S, 1995.
2. Astrup, A., S. Toubro, N.J. Christensen and F. Quaade. Pharmacology of thermogenic drugs. Am. J. Clin. Nutr. 55: 2465-2483, 1992.
3. Bai, F.L., M. Yamano, Y. Shiotani, P.C. Emson, A.D. Smith, J.P. Powell and M. Tohyama. An arcuato-paraventricular and dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res. 331: 172-175, 1985.
4. Beck, B., M. Jhanwar-Uniyal, A. Burlet, M. Chapleur-Chateau, S.F. Leibowitz and C. Burlet. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528: 245-249, 1990.
5. Boozer, C., J. Nasser, S. Heymsfield, V. Wang, G. Chen and J. Solomon. An herbal supplement containing Ma huang-Guarana for weight loss: A randomized, double-blind trial. Int. J. Obes. Relat. Metab. Disord. 25: 316-324, 2001.
6. Boozer, C.N., P.A. Daly, P. Homel, J.L. Solomon, D. Blanchard, J.A. Nasser, R. Strauss and T. Meredith. Herbal ephedra/caffeine for weight loss: A 6-month randomized safety and efficacy trial. Int. J. Obes. Relat. Metab. Disord. 26: 593-604, 2002.
7. Brady, L.S., M.A. Smith, P.W. Gold and M. Herkenham. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52: 441-447, 1990.
8. Broberger, C., J. Johansen, C. Johansson, M. Schalling and T. Hokfelt. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA 95: 15043-15048, 1998.
9. Carek, P.J. and L.M. Dickerson. Current concepts in the pharmacological management of obesity. Drugs 57: 883-904, 1999.
10. Chronwall, B.M., D.A. DiMaggio, V.J. Massari, V.M. Pickel, D.A. Ruggiero and T.L. O'Donohue. The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience 15: 1159-1181, 1985.
11. Dryden, S., S.J. Burns, H.M. Frankish and G. Williams. Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids. Eur. J. Pharmacol. 340: 221-225, 1997.
12. Dulloo, A.G. Ephedrine, xanthines and prostaglandin-inhibitors: Actions and interactions in the stimulation of thermogenesis. Int. J. Obes. Relat. Metab. Disord. 17: 35S-40S, 1993.
13. Elmquist, J.K., C.F. Elias and C.B. Saper. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22: 221-232, 1999.
14. Fouad-Tarazi, F.M., M. Okabe and H. Goren. Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Am. J. Med. 99: 604-610, 1995.
15. Glennon, R.A. and R. Young. (+) Amphetamine-stimulus generalization to an herbal ephedrine product. Pharmacol. Biochem. Behav. 65: 655-658, 2000.
16. Hahn, T., J. Breininger, D. Baskin and M. Schwartz. Co-expression of AGRP and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1: 271-272, 1998.
17. Haller, C.A. and N.L. Benowitz. Adverse cardiovascular and central nervous system events associated with dietary supplements. Res. Commun. Mol. Pathol. Pharmacol. 96: 45-56, 1997.
18. Inui, A. Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin. Trends Neurosci. 22: 62-67, 1999.
19. Jang, M.H., M.C. Shin, B.V. Lim, J.H. Chung, H.S. Kang, S.A. Kang, R.W. Choue, E.H. Kim and C.J. Kim. Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats. Neurosci. Lett. 322: 29-32, 2002.
20. Leibowitz, S.F. Hypothalamic neuropeptide Y in relation to energy balance. Ann. N. Y. Acad. Sci. 611: 284-301, 1990.
21. Makino, T., A. Furuta, H. Fujii, T. Nakagawa, H. Wakushima, K. Saito and Kano, Y. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol. Pharm. Bull. 24: 1206-1209, 2001.
22. Marks, J.L., K. Waite and M. Li. Effects of streptozotocin-induced diabetes mellitus and insulin treatment on neuropeptide Y mRNA in the rat hypothalamus. Diabetologia 36: 497-502, 1993.
23. Marwick, C.J. Growing use of medicinal botanicals forces assessment by drug regulators. J. Am. Med. Assoc. 273: 607-609, 1995.
24. Reinhard, K.J., D.L. Hamilton and R.H. Hevly. Use of pollen concentration in paleopharmacology coprolite evidence of medicinal plants. J. Ethnpharmacol. 11: 117-132, 1991.
25. Stanley, B.G., A.S. Chin and S.F. Leibowitz. Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action. Brain Res. Bull. 14: 521-524, 1985.
26. Stanley, B.G., W. Magdalin, A. Seirafi, M.M. Nguyen and S.F. Leibowitz. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 13: 581-587, 1992.
27. Swanson, L.W. and P.E. Sawchenko. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu. Rev. Neurosci. 6: 269-324, 1983.
28. Walker, R.B., V.N. Dholakia, K.L. Brasfield and R. Bakhitiar. Effect of hydroxypropyl-cyclodextrin on the central stimulant activity of (-)-ephedrine and oxazolidine prodrug in rats. Gen. Pharmacol. 30: 725-731, 1998.
29. White, L.M., S.F. Gardner, B.J. Gurley, M.A. Marx, P.L. Wang and M. Estes. Pharmacokinetics and cardiovascular effects of Ma huang (Ephedra sinica) in normotensive adults. J. Clin. Pharmacol. 37: 116-122, 1997.
30. Williams, G., C. Bing, X.J. Cai, J.A. Harrold, P.J. King and X.H. Liu. The hypothalamus and the control of energy homeostasis different circuits, different purposes. Physiol. Behav. 74: 683-701, 2001.
31. Yuan, D., K. Komatsu, H. Tani, Z. Cui and Y. Kano. Pharmacological properties of traditional medicines. XXIV. Classification of antiasthmatics based on constitutional predispositions. Biol. Pharm. Bull. 21: 1169-1173, 1998.
32. Zaacks, S.M., L. Klein, C.D. Tan, E.R. Rodriguez and J.B. Leikin. Hypersensitivity myocarditis associated with ephedra use. J. Toxicol. Clin. Toxicol. 37: 485-489, 1999.