Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine

Critical Care Medicine

Volumn 28, Issue 11, 2000, Pages 3679-3683

  Zaloga, Gary P ^a   Clark, J Douglas ^b   Roberts, Pamela R ^b  

^a WASHINGTON HOSPITAL CENTER   (United States)

^b WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

Adrenergic; Anor exic; Cardiac; Cardiomyopathy; Diet pills; Nitric oxide; Obesity; Phenylpropanolamine; Toxicity; Vasoconstriction

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLPROPANOLAMINE;

ANIMAL TISSUE; ANOREXIA; ARTICLE; CARDIOTOXICITY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE CONTRACTILITY; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; ISOLATED HEART; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

EID: 0033709494     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200011000-00024     Document Type: Article

References (36)

1. Adverse drug effects attributed to phenylpropanolamine: A review of 142 case reports
2. Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: A placebo controlled follow-up study
3. Hypertensive responses induced by phenylpropanolamine in anorectic and decongestant preparations
4. Phenylpropanolamine: An over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage
5. Cerebral vasculitis and hemorrhage in an adolescent taking diet pills containing phenylpropanolamine: Case report and review of the literature
6. Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule
7. Cardiac arrhythmias in an adolescent following ingestion of an over-the-counter stimulant
8. Phenylpropanolamine-induced arrhythmias
9. Supraventricular tachycardia following the administration of phenylpropanolamine in an infant
10. Death attributed to ventricular arrhythmia
11. Atrioventricular block following overdose of decongestant cold medication
12. Atrioventricular conduction block caused by phenylpropanolamine
13. Pseudopheochromocytoma and cardiac arrest associated with phenylpropanolamine
14. Myocardial injury after phenylpropanolamine ingestion
15. Cardiomyopathy induced by phenylpropanolamine
16. Toxicity of over-the-counter stimulants
17. Endothelium-derived relaxing and contracting factors
18. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart
19. Nitric oxide and platelet aggregation
20. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis
21. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients
22. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension
23. Nitric oxide activity in the atherosclerotic human coronary circulation
24. Flow induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease
25. Nitric oxide deficiency in fenfluramine and dexfenfluramine induced pulmonary hypertension
26. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
27. Basal nitric oxide synthesis in essential hypertension
28. Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease
29. Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells
30. Phenylpropanolamine-induced hypertensive seizures
31. Ischemic bowel infarction and phenylpropanolamine use
32. Complications of phenylpropanolamine
33. Ornade and anticholinergic toxicity: Hypertension, hallucinations, and arrhythmias
34. The influence of drugs on the irritability and automaticity of heart muscle
35. Influence of variations in electrolyte intake upon the development of cardiac necrosis produced by vasopressor amines
36. Focal myocarditis associated with pheochromocytoma