Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 1991-1996

  Cardile, Venera ^a   Lombardo, Laura ^a   Granata, Giuseppe ^a   Perdicaro, Antonio ^a   Balazy, Michael ^b   Santagati, Andrea ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Aminothiopyrimidone; Nitric oxide; NSAIDs; Prostaglandins

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; N [2 [(2,4 DINITROPHENYL)THIO] 4 OXO 6 PHENYLTHIENO[2,3 D]PYRIMIDIN 3(4H) Y]METHANESULFONAMIDE; NITRITE; PROSTAGLANDIN E2; PYRIMIDINONE DERIVATIVE; SULFONAMIDE; THROMBOXANE B2; UNCLASSIFIED DRUG;

ARTICLE; COLORIMETRY; CONTROLLED STUDY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PLASMA; SUPERNATANT;

CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; ENZYME INHIBITORS; HUMANS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PYRIMIDINES; PYRIMIDINONES; SULFONAMIDES;

BACTERIA (MICROORGANISMS);

EID: 61349151830     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.029     Document Type: Article

References (41)

1. Funk C.D., Funk L.B., Kennedy M.E., Pong A.S., and Fitzgerald G.A. FASEB J. 5 (1991) 2304
2. Goppelt-Struebe M. Biophys. Acta 1256 (1995) 257
3. Smith W.L., Meade E.A., and DeWitt D.L. Ann. N.Y. Acad. Sci. 744 (1994) 50
4. Grosser T., Fries S., and Fitzgerald G.A. J. Clin. Invest. 116 (2006) 4
5. Sanchez T., and Moreno J.J. Prostaglandins Other Lipid Mediators 57 (1999) 119
6. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., and Isakson P. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 12013
7. DeWitt D.L. Biochim. Biophys. Acta 1083 (1991) 121
8. Oshima T., Yoshimoto T., Yamamoto S., Kumegawa M., Yokoyama C., and Tanabe T. J. Biol. Chem. 266 (1991) 13621
9. Seibert K., and Masferrer J.L. Receptor 4 (1994) 17
10. Crofford L.J., Wilder R.L., Ristimaki A.P., Sano H., Remmers E.F., Epps H.R., and Hla T. J. Clin. Invest. 93 (1994) 1095
11. Kujubu D.A., Fletcher B.S., Varnum B.C., Lim R.W., and Herschman H.R. J. Biol. Chem. 266 (1991) 12866
12. O'Banion M.K., Winn V.D., and Young D.A. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 4888
13. Fu J.Y., Masferrer J.L., Seibert K., Raz A., and Needleman P. J. Biol. Chem. 265 (1990) 16737
14. Masferrer J.L., Zweifel B.S., Seibert K., and Needleman P. J. Clin. Invest. 86 (1990) 1375
15. Lee S.H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., Liou S., Simmons D., and Hwang D. J. Biol. Chem. 267 (1992) 25934
16. O'Sullivan M.G., Huggins Jr. E.M., Meade E.A., DeWitt D.L., and McCall C.E. Biochem. Biophys. Res. Commun. 187 (1992) 1123
17. Sano H., Hla T., Maier J.A., Crofford L.J., Case J.P., Maciag T., and Wilder R.L. J. Clin. Invest. 89 (1992) 97
18. Sirois J., and Richards J.S. J. Biol. Chem. 267 (1992) 6382
19. Masferrer J.L., Seibert K., Zweifel B., and Needleman P. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3917
20. Masferrer J.L., Reddy S.T., Zweifel B.S., Seibert K., Needleman P., Gilbert R.S., and Herschman H.R. J. Pharmacol. Exp. Ther. 270 (1994) 1340
21. Vane J.R., Bakhle Y.S., and Botting R.M. Annu. Rev. Pharmacol. Toxicol. 38 (1998) 97
22. Bateman D.N. Lancet 343 (1994) 1051
23. Kim S.F., Huri D.A., and Snyder S.H. Science 310 (2005) 1966
24. Appleton I., Tomlinson A., and Willoughby D.A. Adv. Pharmacol. 35 (1996) 27
25. Santagati A., Granata G., Marrazzo A., and Santagati M. Arch. Pharm. (Weinheim) 336 (2003) 429
26. Granata G., Barbagallo S., Marrazzo A., Santagati A., Lombardo L., and Cardile V. J. Heterocyl. Chem. 43 (2006) 1099
27. Brideau C., Kargman S., Liu S., Dallob A.L., Ehrich E.W., Rodger I.W., and Chan C.C. Inflamm. Res. 45 (1996) 68
28. Balazy M., and Poff C.D. Curr. Vasc. Pharmacol. 2 (2004) 81
29. Kermorvant-Duchemin E., Sennlaub F., Sirinyan M., Brault S., Andelfinger G., Kooli A., Germain S., Ong H., d'Orleans-Juste P., Gobeil F., Zhu T., Boisvert C., Hardy P., Jain K., Falck J.R., Balazy M., and Chemtob S. Nat. Med. 11 (2005) 1339
30. Tsai A.L., Wei C., and Kulmacz R.J. Arch. Biochem. Biophys. 313 (1994) 367
31. Yang T., Zhang A., Pasumarthy A., Zhang L., Warnock Z., and Schnermann J.B. Am. J. Physiol. Renal Physiol. 291 (2006) F891
32. Bing R.J., Miyataka M., Rich K.A., Hanson N., Wang X., Slosser H.D., and Shi S.R. Clin. Cancer Res. 7 (2001) 3385
33. Gasparini G., Longo R., Sarmiento R., and Morabito A. Lancet Oncol. 4 (2003) 605
34. Balsamo A., Mancini F., Milanese C., Orlandini E., Ortore G., Pinza M., Rapposelli S., and Rossello A. Il Farmaco 58 (2003) 707
35. Santagati A., Modica M., Monsù Scolaro M., and Santagati M. J. Chem. Res. (S) 5 (1999) 86
36. Santagati A., Modica M., and Santagati M. J. Heterocycl. Chem. 37 (2000) 1161
37. Santagati A., Granata G., Marrazzo A., and Santagati M. Arch. Pharm. Pharm. Med. Chem. 336 (2003) 429
38. Santagati A., Marrazzo A., and Granata G. J. Heterocycl. Chem. 40 (2003) 869
39. Patrignani P., Panara M.R., Greco A., Fusco O., Natoli C., Iacobelli S., Cipollone F., Ganci A., Creminon C., and Maclouf J. J. Pharmacol. Exp. Ther. 271 (1994) 1705
40. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Anal. Biochem. 126 (1982) 131
41. Ding A.H., Nathan C.F., and Stuehr D.J. J. Immunol. 141 (1988) 2407