Synthesis and effects on the COX-1 and COX-2 activity in human whole blood ex vivo of derivatives containing the [1]benzothienol-[3,2-d]pyrimidin-4-one heterocyclic system

Archiv der Pharmazie

Volumn 336, Issue 9, 2003, Pages 429-435

  Santagati, Andrea ^a   Granata, Giuseppe ^a   Marrazzo, Agostino ^a   Santagati, Maria ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

1 Benzothieno 3,2 d pyrimidin 4 one; Cyclooxygenase (COX 1, COX 2); NSAIDs (non steroidal anti inflammatory drugs); Selective COX 2 inhibitors

Indexed keywords

[1]BENZOTHIENO[3,2 D]PYRIMIDIN 4 ONE; ACETYLSALICYLIC ACID; ALPHA [(3 AMINO 3,4 DIHYDRO 4 OXO [1]BENZOTHIENO[3,2 D]PYRIMIDIN 2 YL)THIO]PHENYLACETIC ACID; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; HETEROCYCLIC COMPOUND; PHENYLACETIC ACID DERIVATIVE; PROSTAGLANDIN E2; PYRIMIDINE DERIVATIVE; THROMBOXANE B2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD ANALYSIS; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INHIBITION KINETICS; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0142107000     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300753     Document Type: Article

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