The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells

Journal of Neurochemistry

Volumn 108, Issue 6, 2009, Pages 1434-1441

  Lee, Hyun Pil ^a   Zhu, Xiaochun ^b   Zhu, Xiongwei ^a   Skidmore, S Chad ^b   Perry, George ^a,c   Sayre, Lawrence M ^b   Smith, Mark A ^a   Lee, Hyoung Gon ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c The University of Texas at San Antonio   (United States)

Author keywords

4 hydroxynonenal; 4 oxo 2 nonenal; Cytotoxicity; Lipid peroxidation; Mitogen activated protein kinase; Neurodegeneration; Oxidative stress; Protein modification

Indexed keywords

4 OXO 2 NONENAL; FATTY ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ALDEHYDES; CELL DEATH; CELL LINE, TUMOR; COLLAGEN TYPE XI; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; L-LACTATE DEHYDROGENASE; MAP KINASE KINASE 4; NEUROBLASTOMA; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 61349123614     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05883.x     Document Type: Article

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