메뉴 건너뛰기




Volumn 91, Issue 3, 2009, Pages 842-850

A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome

Author keywords

adiponectin; cortisol; free fatty acids; growth hormone; IGF I; insulin sensitivity; PCOS; PPAR ; steroid metabolites

Indexed keywords

ADIPONECTIN; ANDROSTANOLONE; ANDROSTERONE; ETIOCHOLANOLONE; HYDROCORTISONE; INSULIN; PIOGLITAZONE; PLACEBO; PRASTERONE; PRASTERONE SULFATE; PYRIDOSTIGMINE; SOMATOMEDIN C; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TETRAHYDROCORTISOL;

EID: 61349122771     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.12.082     Document Type: Article
Times cited : (21)

References (54)
  • 1
    • 15944413193 scopus 로고    scopus 로고
    • Significantly higher adrenocorticotropin-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, caucasian, hirsute patients compared with healthy controls
    • Glintborg D., Hermann A.P., Brusgaard K., Hangaard J., Hagen C., and Andersen M. Significantly higher adrenocorticotropin-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, caucasian, hirsute patients compared with healthy controls. J Clin Endocrinol Metab 90 (2005) 1347-1353
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1347-1353
    • Glintborg, D.1    Hermann, A.P.2    Brusgaard, K.3    Hangaard, J.4    Hagen, C.5    Andersen, M.6
  • 2
    • 0031758126 scopus 로고    scopus 로고
    • Adrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axis
    • Azziz R., Black V., Hines G.A., Fox L.M., and Boots L.R. Adrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 83 (1998) 2317-2323
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2317-2323
    • Azziz, R.1    Black, V.2    Hines, G.A.3    Fox, L.M.4    Boots, L.R.5
  • 3
    • 0033151669 scopus 로고    scopus 로고
    • Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome
    • Kelestimur F., and Sahin Y. Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome. Fertil Steril 71 (1999) 1075-1078
    • (1999) Fertil Steril , vol.71 , pp. 1075-1078
    • Kelestimur, F.1    Sahin, Y.2
  • 4
    • 0343683306 scopus 로고    scopus 로고
    • Body fat distribution, insulin resistance, and metabolic diseases
    • Bjorntorp P. Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 13 (1997) 795-803
    • (1997) Nutrition , vol.13 , pp. 795-803
    • Bjorntorp, P.1
  • 6
    • 0027958129 scopus 로고
    • Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase
    • Rodin A., Thakkar H., Taylor N., and Clayton R. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. N Engl J Med 330 (1994) 460-465
    • (1994) N Engl J Med , vol.330 , pp. 460-465
    • Rodin, A.1    Thakkar, H.2    Taylor, N.3    Clayton, R.4
  • 7
    • 0033622064 scopus 로고    scopus 로고
    • Increased 5alpha-reductase and normal 11beta-hydroxysteroid dehydrogenase metabolism of C19 and C21 steroids in a young population with polycystic ovarian syndrome
    • Chin D., Shackleton C., Prasad V.K., Kohn B., David R., Imperato-McGinley J., et al. Increased 5alpha-reductase and normal 11beta-hydroxysteroid dehydrogenase metabolism of C19 and C21 steroids in a young population with polycystic ovarian syndrome. J Pediatr Endocrinol Metab 13 (2000) 253-259
    • (2000) J Pediatr Endocrinol Metab , vol.13 , pp. 253-259
    • Chin, D.1    Shackleton, C.2    Prasad, V.K.3    Kohn, B.4    David, R.5    Imperato-McGinley, J.6
  • 8
    • 0037902870 scopus 로고    scopus 로고
    • Beyond adrenal and ovarian androgen generation: increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    • Fassnacht M., Schlenz N., Schneider S.B., Wudy S.A., Allolio B., and Arlt W. Beyond adrenal and ovarian androgen generation: increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88 (2003) 2760-2766
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2760-2766
    • Fassnacht, M.1    Schlenz, N.2    Schneider, S.B.3    Wudy, S.A.4    Allolio, B.5    Arlt, W.6
  • 9
    • 23844516967 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action
    • Draper N., and Stewart P.M. 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol 186 (2005) 251-271
    • (2005) J Endocrinol , vol.186 , pp. 251-271
    • Draper, N.1    Stewart, P.M.2
  • 10
    • 0034969823 scopus 로고    scopus 로고
    • Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase
    • Tomlinson J.W., and Stewart P.M. Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase. Best Pract Res Clin Endocrinol Metab 15 (2001) 61-78
    • (2001) Best Pract Res Clin Endocrinol Metab , vol.15 , pp. 61-78
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 12
    • 33744490613 scopus 로고    scopus 로고
    • Content of 5-alpha-reductase (type 1 and type 2) mRNA in dermal papillae from the lower abdominal region in women with hirsutism
    • Skalba P., Dabkowska-Huc A., Kazimierczak W., Samojedny A., Samojedny M.P., and Chelmicki Z. Content of 5-alpha-reductase (type 1 and type 2) mRNA in dermal papillae from the lower abdominal region in women with hirsutism. Clin Exp Dermatol 31 (2006) 564-570
    • (2006) Clin Exp Dermatol , vol.31 , pp. 564-570
    • Skalba, P.1    Dabkowska-Huc, A.2    Kazimierczak, W.3    Samojedny, A.4    Samojedny, M.P.5    Chelmicki, Z.6
  • 13
    • 0021967783 scopus 로고
    • Increased 5 alpha-reductase activity in idiopathic hirsutism
    • Serafini P., and Lobo R.A. Increased 5 alpha-reductase activity in idiopathic hirsutism. Fertil Steril 43 (1985) 74-78
    • (1985) Fertil Steril , vol.43 , pp. 74-78
    • Serafini, P.1    Lobo, R.A.2
  • 14
    • 0347362865 scopus 로고    scopus 로고
    • Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates
    • Tsilchorozidou T., Honour J.W., and Conway G.S. Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates. J Clin Endocrinol Metab 88 (2003) 5907-5913
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5907-5913
    • Tsilchorozidou, T.1    Honour, J.W.2    Conway, G.S.3
  • 15
    • 0033237665 scopus 로고    scopus 로고
    • 5alpha-reductase activity in women with polycystic ovary syndrome
    • Jakimiuk A.J., Weitsman S.R., and Magoffin D.A. 5alpha-reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 84 (1999) 2414-2418
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2414-2418
    • Jakimiuk, A.J.1    Weitsman, S.R.2    Magoffin, D.A.3
  • 16
    • 10044250257 scopus 로고    scopus 로고
    • The prevalence of endocrine diseases and abnormal glucose tolerance tests in 340 caucasian, premenopausal women with hirsutism as primary diagnosis
    • Glintborg D., Henriksen J.E., Andersen M., Hagen C., Hangaard J., Rasmussen P., et al. The prevalence of endocrine diseases and abnormal glucose tolerance tests in 340 caucasian, premenopausal women with hirsutism as primary diagnosis. Fertil Steril 82 (2004) 1570-1579
    • (2004) Fertil Steril , vol.82 , pp. 1570-1579
    • Glintborg, D.1    Henriksen, J.E.2    Andersen, M.3    Hagen, C.4    Hangaard, J.5    Rasmussen, P.6
  • 17
    • 0032422233 scopus 로고    scopus 로고
    • Growth hormone and ovarian function
    • Franks S. Growth hormone and ovarian function. Baillieres Clin Endocrinol Metab 12 (1998) 331-340
    • (1998) Baillieres Clin Endocrinol Metab , vol.12 , pp. 331-340
    • Franks, S.1
  • 18
    • 0030025398 scopus 로고    scopus 로고
    • Growth hormone and fertility-clinical studies
    • Homburg R. Growth hormone and fertility-clinical studies. Horm Res 45 (1996) 81-85
    • (1996) Horm Res , vol.45 , pp. 81-85
    • Homburg, R.1
  • 19
    • 0141724824 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome
    • CD003053
    • Lord J.M., Flight I.H., and Norman R.J. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev (2003) CD003053
    • (2003) Cochrane Database Syst Rev
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 20
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: systematic review and meta-analysis
    • Lord J.M., Flight I.H., and Norman R.J. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327 (2003) 951-953
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 21
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson A.B., Hundal R.S., Dufour S., Lebon V., Befroy D., Cline G.W., et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51 (2002) 797-802
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3    Lebon, V.4    Befroy, D.5    Cline, G.W.6
  • 22
    • 0036072223 scopus 로고    scopus 로고
    • Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
    • Miyazaki Y., Mahankali A., Matsuda M., Mahankali S., Hardies J., Cusi K., et al. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 87 (2002) 2784-2791
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2784-2791
    • Miyazaki, Y.1    Mahankali, A.2    Matsuda, M.3    Mahankali, S.4    Hardies, J.5    Cusi, K.6
  • 23
    • 26244435420 scopus 로고    scopus 로고
    • Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome
    • Glintborg D., Stoving R.K., Hagen C., Hermann A.P., Frystyk J., Veldhuis J.D., et al. Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome. J Clin Endocrinol Metab 90 (2005) 5605-5612
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5605-5612
    • Glintborg, D.1    Stoving, R.K.2    Hagen, C.3    Hermann, A.P.4    Frystyk, J.5    Veldhuis, J.D.6
  • 24
    • 0034519393 scopus 로고    scopus 로고
    • Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats
    • Livingstone D.E., Kenyon C.J., and Walker B.R. Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol 167 (2000) 533-539
    • (2000) J Endocrinol , vol.167 , pp. 533-539
    • Livingstone, D.E.1    Kenyon, C.J.2    Walker, B.R.3
  • 25
    • 33746537783 scopus 로고    scopus 로고
    • Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome
    • Glintborg D., Hermann A.P., Andersen M., Hagen C., Beck-Nielsen H., Veldhuis J.D., and Henriksen J.E. Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome. Fertil Steril 86 (2006) 385-397
    • (2006) Fertil Steril , vol.86 , pp. 385-397
    • Glintborg, D.1    Hermann, A.P.2    Andersen, M.3    Hagen, C.4    Beck-Nielsen, H.5    Veldhuis, J.D.6    Henriksen, J.E.7
  • 26
    • 0022389327 scopus 로고
    • Abnormal androgen and oestrogen metabolism in men with steroid sulphatase deficiency and recessive X-linked ichthyosis
    • Lykkesfeldt G., Bennett P., Lykkesfeldt A.E., Micic S., Moller S., and Svenstrup B. Abnormal androgen and oestrogen metabolism in men with steroid sulphatase deficiency and recessive X-linked ichthyosis. Clin Endocrinol (Oxf) 23 (1985) 385-393
    • (1985) Clin Endocrinol (Oxf) , vol.23 , pp. 385-393
    • Lykkesfeldt, G.1    Bennett, P.2    Lykkesfeldt, A.E.3    Micic, S.4    Moller, S.5    Svenstrup, B.6
  • 27
    • 0029615371 scopus 로고
    • Noncompetitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II
    • Frystyk J., Dinesen B., and Orskov H. Noncompetitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5 (1995) 169-176
    • (1995) Growth Regul , vol.5 , pp. 169-176
    • Frystyk, J.1    Dinesen, B.2    Orskov, H.3
  • 28
    • 24944545643 scopus 로고    scopus 로고
    • Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications
    • Frystyk J., Tarnow L., Krarup H.T., Parving H.H., and Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia 48 (2005) 1911-1918
    • (2005) Diabetologia , vol.48 , pp. 1911-1918
    • Frystyk, J.1    Tarnow, L.2    Krarup, H.T.3    Parving, H.H.4    Flyvbjerg, A.5
  • 29
    • 0015420770 scopus 로고
    • Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome
    • Nielsen M.D., Lund J.O., and Munck O. Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. Acta Endocrinol (Copenh) 71 (1972) 498-511
    • (1972) Acta Endocrinol (Copenh) , vol.71 , pp. 498-511
    • Nielsen, M.D.1    Lund, J.O.2    Munck, O.3
  • 30
    • 0014479819 scopus 로고
    • Urinary excretion of different corticosteroid-metabolites in oral contraception and pregnancy
    • Nielsen M.D., Binder C., and Starup J. Urinary excretion of different corticosteroid-metabolites in oral contraception and pregnancy. Acta Endocrinol (Copenh) 60 (1969) 473-485
    • (1969) Acta Endocrinol (Copenh) , vol.60 , pp. 473-485
    • Nielsen, M.D.1    Binder, C.2    Starup, J.3
  • 31
    • 0029847585 scopus 로고    scopus 로고
    • Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man
    • Palermo M., Shackleton C.H., Mantero F., and Stewart P.M. Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf) 45 (1996) 605-611
    • (1996) Clin Endocrinol (Oxf) , vol.45 , pp. 605-611
    • Palermo, M.1    Shackleton, C.H.2    Mantero, F.3    Stewart, P.M.4
  • 32
    • 0027414682 scopus 로고
    • Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research
    • Shackleton C.H. Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research. J Steroid Biochem Mol Biol 45 (1993) 127-140
    • (1993) J Steroid Biochem Mol Biol , vol.45 , pp. 127-140
    • Shackleton, C.H.1
  • 33
    • 0026015905 scopus 로고
    • Approximate entropy as a measure of system complexity
    • Pincus S.M. Approximate entropy as a measure of system complexity. Proc Natl Acad Sci U S A 88 (1991) 2297-2301
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2297-2301
    • Pincus, S.M.1
  • 35
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif A., Xia J., Book C.B., Schenker E., and Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 96 (1995) 801-810
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3    Schenker, E.4    Tang, Z.5
  • 36
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome
    • Zhang L.H., Rodriguez H., Ohno S., and Miller W.L. Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci U S A 92 (1995) 10619-10623
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10619-10623
    • Zhang, L.H.1    Rodriguez, H.2    Ohno, S.3    Miller, W.L.4
  • 37
    • 34347238610 scopus 로고    scopus 로고
    • Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic ovary syndrome
    • Romualdi D., Giuliani M., Draisci G., Costantini B., Cristello F., Lanzone A., and Guido M. Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic ovary syndrome. Fertil Steril 88 (2007) 131-138
    • (2007) Fertil Steril , vol.88 , pp. 131-138
    • Romualdi, D.1    Giuliani, M.2    Draisci, G.3    Costantini, B.4    Cristello, F.5    Lanzone, A.6    Guido, M.7
  • 38
    • 0038508940 scopus 로고    scopus 로고
    • Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome
    • Romualdi D., Guido M., Ciampelli M., Giuliani M., Leoni F., Perri C., and Lanzone A. Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome. Hum Reprod 18 (2003) 1210-1218
    • (2003) Hum Reprod , vol.18 , pp. 1210-1218
    • Romualdi, D.1    Guido, M.2    Ciampelli, M.3    Giuliani, M.4    Leoni, F.5    Perri, C.6    Lanzone, A.7
  • 39
    • 4043100289 scopus 로고    scopus 로고
    • Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome
    • Brettenthaler N., De Geyter C., Huber P.R., and Keller U. Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 89 (2004) 3835-3840
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3835-3840
    • Brettenthaler, N.1    De Geyter, C.2    Huber, P.R.3    Keller, U.4
  • 40
    • 1542502601 scopus 로고    scopus 로고
    • Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome
    • Guido M., Romualdi D., Suriano R., Giuliani M., Costantini B., Apa R., and Lanzone A. Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome. Hum Reprod 19 (2004) 534-539
    • (2004) Hum Reprod , vol.19 , pp. 534-539
    • Guido, M.1    Romualdi, D.2    Suriano, R.3    Giuliani, M.4    Costantini, B.5    Apa, R.6    Lanzone, A.7
  • 41
    • 0035951661 scopus 로고    scopus 로고
    • Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme
    • Charbonneau A., and The V.L. Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme. Biochim Biophys Acta 1517 (2001) 228-235
    • (2001) Biochim Biophys Acta , vol.1517 , pp. 228-235
    • Charbonneau, A.1    The, V.L.2
  • 42
    • 0033651783 scopus 로고    scopus 로고
    • Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome
    • Walker B.R., Rodin A., Taylor N.F., and Clayton R.N. Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome. Clin Endocrinol (Oxf) 52 (2000) 77-80
    • (2000) Clin Endocrinol (Oxf) , vol.52 , pp. 77-80
    • Walker, B.R.1    Rodin, A.2    Taylor, N.F.3    Clayton, R.N.4
  • 43
    • 0035918143 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta-hydroxysteroid dehydrogenase type 1 expression and activity
    • Berger J., Tanen M., Elbrecht A., Hermanowski-Vosatka A., Moller D.E., Wright S.D., and Thieringer R. Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. J Biol Chem 276 (2001) 12629-12635
    • (2001) J Biol Chem , vol.276 , pp. 12629-12635
    • Berger, J.1    Tanen, M.2    Elbrecht, A.3    Hermanowski-Vosatka, A.4    Moller, D.E.5    Wright, S.D.6    Thieringer, R.7
  • 44
    • 15944413193 scopus 로고    scopus 로고
    • Significantly higher ACTH-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, caucasian, hirsute patients compared to healthy controls
    • Glintborg D., Hermann A., Brusgaard K., Hangaard J., Hagen C., and Andersen M. Significantly higher ACTH-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, caucasian, hirsute patients compared to healthy controls. J Clin Endocrinol Metab 90 (2005) 1347-1353
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1347-1353
    • Glintborg, D.1    Hermann, A.2    Brusgaard, K.3    Hangaard, J.4    Hagen, C.5    Andersen, M.6
  • 45
    • 0036216342 scopus 로고    scopus 로고
    • Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome
    • Vrbikova J., Bicikova M., Tallova J., Hill M., and Starka L. Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 110 (2002) 74-76
    • (2002) Exp Clin Endocrinol Diabetes , vol.110 , pp. 74-76
    • Vrbikova, J.1    Bicikova, M.2    Tallova, J.3    Hill, M.4    Starka, L.5
  • 46
    • 0037299936 scopus 로고    scopus 로고
    • Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome
    • Kazerooni T., and Dehghan-Kooshkghazi M. Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome. Gynecol Endocrinol 17 (2003) 51-56
    • (2003) Gynecol Endocrinol , vol.17 , pp. 51-56
    • Kazerooni, T.1    Dehghan-Kooshkghazi, M.2
  • 47
    • 84864214362 scopus 로고    scopus 로고
    • Insulin-sensitizing agents and their effect on adrenal androgens
    • Unluhizarci K., Kelestimur F., and Bayram F. Insulin-sensitizing agents and their effect on adrenal androgens. Fertil Steril 74 (2000) 1058-1059
    • (2000) Fertil Steril , vol.74 , pp. 1058-1059
    • Unluhizarci, K.1    Kelestimur, F.2    Bayram, F.3
  • 48
    • 33748042964 scopus 로고    scopus 로고
    • Metformin versus rosiglitazone in the treatment of polycystic ovary syndrome
    • Mitkov M., Pehlivanov B., and Terzieva D. Metformin versus rosiglitazone in the treatment of polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 126 (2006) 93-98
    • (2006) Eur J Obstet Gynecol Reprod Biol , vol.126 , pp. 93-98
    • Mitkov, M.1    Pehlivanov, B.2    Terzieva, D.3
  • 49
    • 0036283875 scopus 로고    scopus 로고
    • Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance
    • Arslanian S.A., Lewy V., Danadian K., and Saad R. Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 87 (2002) 1555-1559
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1555-1559
    • Arslanian, S.A.1    Lewy, V.2    Danadian, K.3    Saad, R.4
  • 50
    • 0032730796 scopus 로고    scopus 로고
    • Effects of metformin on adrenal steroidogenesis in women with polycystic ovary syndrome
    • La Marca A., Morgante G., Paglia T., Ciotta L., Cianci A., and De Leo V. Effects of metformin on adrenal steroidogenesis in women with polycystic ovary syndrome. Fertil Steril 72 (1999) 985-989
    • (1999) Fertil Steril , vol.72 , pp. 985-989
    • La Marca, A.1    Morgante, G.2    Paglia, T.3    Ciotta, L.4    Cianci, A.5    De Leo, V.6
  • 51
    • 0035041906 scopus 로고    scopus 로고
    • Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial
    • Azziz R., Ehrmann D., Legro R.S., Whitcomb R.W., Hanley R., Fereshetian A.G., et al. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab 86 (2001) 1626-1632
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1626-1632
    • Azziz, R.1    Ehrmann, D.2    Legro, R.S.3    Whitcomb, R.W.4    Hanley, R.5    Fereshetian, A.G.6
  • 52
    • 0042624707 scopus 로고    scopus 로고
    • Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin
    • Glueck C.J., Moreira A., Goldenberg N., Sieve L., and Wang P. Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin. Hum Reprod 18 (2003) 1618-1625
    • (2003) Hum Reprod , vol.18 , pp. 1618-1625
    • Glueck, C.J.1    Moreira, A.2    Goldenberg, N.3    Sieve, L.4    Wang, P.5
  • 53
    • 0029795871 scopus 로고    scopus 로고
    • The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
    • Dunaif A., Scott D., Finegood D., Quintana B., and Whitcomb R. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 81 (1996) 3299-3306
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3299-3306
    • Dunaif, A.1    Scott, D.2    Finegood, D.3    Quintana, B.4    Whitcomb, R.5
  • 54
    • 33749035259 scopus 로고    scopus 로고
    • Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study
    • Rautio K., Tapanainen J.S., Ruokonen A., and Morin-Papunen L.C. Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study. Hum Reprod 21 (2006) 1400-1407
    • (2006) Hum Reprod , vol.21 , pp. 1400-1407
    • Rautio, K.1    Tapanainen, J.S.2    Ruokonen, A.3    Morin-Papunen, L.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.