Endogenous inhibitors of 11β-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome

Clinical Endocrinology

Volumn 52, Issue 1, 2000, Pages 77-80

  Walker, Brian R ^a   Rodin, Andrew ^b   Taylor, Norman F ^c   Clayton, Richard N ^d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ST HELIER HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; HYDROCORTISONE; STEROID 5BETA REDUCTASE; CORTISONE; ENZYME INHIBITOR; HYDROXYSTEROID DEHYDROGENASE;

ARTICLE; CONTROLLED STUDY; HORMONE METABOLISM; HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; NEGATIVE FEEDBACK; OVARY POLYCYSTIC DISEASE; PREMENOPAUSE; PRIORITY JOURNAL; ADOLESCENT; ADULT; ANIMAL; BIOASSAY; CASE CONTROL STUDY; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; LIVER MICROSOME; METABOLISM; RAT; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL ASSAY; CASE-CONTROL STUDIES; CORTISONE; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; MICROSOMES, LIVER; POLYCYSTIC OVARY SYNDROME; RATS;

EID: 0033651783     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00893.x     Document Type: Article

References (27)

1. Agarwal, A.K., Monder, C., Eckstein, B. & White, P.C. (1989) Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. Journal of Biological Chemistry, 264, 18939-18943.
2. +-dependent isoform of 11β-hydroxysteroid dehydrogenase. Cloning and characterisation of cDNA from sheep kidney. Journal of Biological Chemistry, 269, 25959-25962.
3. Albiston, A.L., Obeyesekere, V.R., Smith, R.E. & Krozowski, Z.S. (1994) Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Molecular and Cellular Endocrinology, 105, R11-R17.
4. Andrew, R., Phillips, D.I.W. & Walker, B.R. (1998) Obesity and gender influence cortisol secretion and metabolism in man. Journal of Clinical Endocrinology and Metabolism, 83, 1806-1809.
5. Bujalska, I.J., Kumar, S. & Stewart, P.M. (1997) Does central obesity reflect 'Cushing's disease of the omentum'? Lancet, 349, 1210-1213.
6. Conway, G.S., Honour, J.W. & Jacobs, H.S. (1989) Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clinical Endocrinology, 30, 459-470.
7. Dunaif, A., Scott, D., Finegood, D., Quintana, B. & Whitcomb, R. (1996) The insulin-sensitising agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 81, 3299-3306.
8. Finken, M.J.J., Andrews, R.C., Andrew, R. & Walker, B.R. (1999) Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductase but not 11 β-hydroxysteroid dehydrogenases. Journal of Clinical Endocrinology and Metabolism, 84, 3316-3321.
9. Fraser, R., Ingram, M.C., Anderson, N.H., Morrison, C., Davies, E. & Connell, J.M.C. (1999) Cortisol effects on body mass, blood pressure, and cholesterol in the general population. American Journal of Physiology - Endocrinology and Metabolism, 33, 1364-1368.
10. Hammami, M.M. & Siiteri, P.K. (1991) Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. Journal of Clinical Endocrinology and Metabolism, 73, 326-334.
11. Jamieson, A., Wallace, A.M., Walker, B.R., Andrew, R., Fraser, R., White, P.C. & Connell, J.M.C. (1999) Apparent cortisone reductase deficiency: a defect in 11β-hydroxysteroid dehydrogenase type 1 or in cortisone 5β-reductase? Journal of Clinical Endocrinology and Metabolism, 84, 3570-3574.
12. Low, S.C., Chapman, K.E., Edwards, C.R.W., Wells, T., Robinson, I.C.A.F. & Seckl, J.R. (1994) Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. Journal of Endocrinology, 143, 541-548.
13. Morris, D.J., Semafuko, W.E.B., Latif, S.A., Vogel, B., Grimes, C. & Sheff, M.F. (1992) Detection of glycyrrhetinic acid-like factors (GALFs) in human urine. Hypertension, 20, 356-360.
14. Perschel, F.H., Buhler, H. & Hierholzer, K. (1991) Bile acids and their amidates inhibit 11β-hydroxysteroid dehydrogenase obtained from rat kidney. Pflugers Archives, 418, 538-543.
15. Phillipou, G. & Higgins, B.A. (1985) A new defect in the peripheral conversion of cortisone to cortisol. Journal of Steroid Biochemistry, 22, 435-436.
16. Phillipou, G., Palermo, M. & Shackleton, C.H.L. (1996) Apparent cortisone reductase deficiency; a unique form of hypercortisolism. Journal of Clinical Endocrinology and Metabolism, 81, 3855-3860.
17. Rodin, A., Thakkar, H., Taylor, N. & Clayton, R. (1994) Hyperandrogenism in polycystic ovary syndrome: evidence of dysregulation of 11beta-hydroxysteroid dehydrogenase. New England Journal of Medicine, 330, 460-465.
18. Semafuko, W.E.B., Sheff, M.F., Grimes, C.A., Latif, S.A., Sadaniantz, A., Levinson, P. & Morris, D.J. (1993) Inhibitors of 11β-hydroxysteroid dehydrogenase and 5β-steroid reductase in urine from patients with congestive heart failure. Annals of Clinical and Laboratory Science, 23, 456-461.
19. Souness, G.W., Latif, S.A., Laurenzo, J.L. & Morris, D.J. (1995) 11alpha-and 11beta-hydroxyprogesterone, potent inhibitors of 11beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat. Endocrinology, 136, 1809-1812.
20. Stewart, P.M., Shackleton, C.H.L., Beastall, G.H. & Edwards, C.R.W. (1990) 5alpha-reductase activity in polycystic ovarian syndrome. Lancet, 335, 431-433.
21. Stewart, P.M., Boulton, A., Kumar, S., Clark, P.M.S. & Shackleton, C.H.L. (1999) Cortisol metabolism in human obesity: impaired cortisone - cortisol conversion in subjects with central adiposity. Journal of Clinical Endocrinology and Metabolism, 84, 1022-1027.
22. Takeda, Y., Miyamori, I., Iki, K., Inaba, S., Furukawa, K., Hatakeyama, H., Yoneda, T. & Takeda, R. (1996) Endogenous renal 11β-hydroxysteroid dehydrogenase inhibitory factors in patients with low-renin essential hypertension. Hypertension, 27, 197-201.
23. Walker, B.R., Campbell, J.C., Fraser, R., Stewart, P.M. & Edwards, C.R.W. (1992) Mineralocorticoid excess and inhibition of 11β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clinical Endocrinology, 27, 483-492.
24. Walker, B.R., Aggarwal, I., Stewart, P.M., Padfield, P.L. & Edwards, C.R.W. (1995a) Endogenous inhibitors of 11β-hydroxysteroid dehydrogenase in hypertension. Journal of Clinical Endocrinology and Metabolism, 80, 529-533.
25. Walker, B.R., Williamson, P.M., Brown, M.A., Honour, J.W., Edwards, C.R.W. & Whitworth, J.A. (1995b) 11β-Hydroxysteroid dehydrogenase and its inhibitors in hypertensive pregnancy. Hypertension, 25, 626-630.
26. Weaver, J.U., Thaventhiran, L., Noonan, K., Burrin, J.M., Taylor, N.F., Norman, M.R. & Monson, J.P. (1994) The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults. Clinical Endocrinology, 41, 639-648.
27. Weaver, J.U., Taylor, N.F., Monson, J.P., Wood, P.J. & Kelly, W.F. (1998) Sexual dimorphism in 11 beta hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects. Clinical Endocrinology, 49, 13-20.