-
2
-
-
0034871451
-
A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
-
Lacroix M, Abi-Said D, Fourney DR et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J. Neurosurg. 95, 190-198 (2001).
-
(2001)
J. Neurosurg
, vol.95
, pp. 190-198
-
-
Lacroix, M.1
Abi-Said, D.2
Fourney, D.R.3
-
3
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
4
-
-
33646555670
-
Results from Phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas
-
Presented at:, Orlando, FL, USA, 13-17 May
-
Fine HA, Kim L, Royce C et al. Results from Phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas. Presented at: 42nd ASCO Annual Meeting. Orlando, FL, USA, 13-17 May 2005.
-
(2005)
42nd ASCO Annual Meeting
-
-
Fine, H.A.1
Kim, L.2
Royce, C.3
-
5
-
-
0037161024
-
Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
-
Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359, 1011-1018 (2002).
-
(2002)
Lancet
, vol.359
, pp. 1011-1018
-
-
Stewart, L.A.1
-
6
-
-
0032767387
-
Outcomes and prognostic factors in recurrent glioma patients enrolled onto Phase clinical trials
-
Wong ET, Hess KR, Gleason MJ et al. Outcomes and prognostic factors in recurrent glioma patients enrolled onto Phase clinical trials. J. Clin. Oncol. 17, 2572-2578 (1999).
-
(1999)
J. Clin. Oncol
, vol.17
, pp. 2572-2578
-
-
Wong, E.T.1
Hess, K.R.2
Gleason, M.J.3
-
8
-
-
33645732219
-
Molecular pathology of malignant gliomas
-
Louis DN. Molecular pathology of malignant gliomas. Annu. Rev. Pathol. 1, 97-117 (2006).
-
(2006)
Annu. Rev. Pathol
, vol.1
, pp. 97-117
-
-
Louis, D.N.1
-
9
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat. Rev. Cancer 4, 937-947 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
10
-
-
36949034117
-
Mechanisms of disease: The PI3K-Akt-PTEN signaling node - an intercept point for the control of angiogenesis in brain tumors
-
Castellino RC, Durden DL. Mechanisms of disease: the PI3K-Akt-PTEN signaling node - an intercept point for the control of angiogenesis in brain tumors. Nat. Clin. Pract. Neurol. 3, 682-693 (2007).
-
(2007)
Nat. Clin. Pract. Neurol
, vol.3
, pp. 682-693
-
-
Castellino, R.C.1
Durden, D.L.2
-
11
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J. Clin. Oncol. 22, 2954-2963 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
12
-
-
51849084360
-
The PTEN-PI3K pathway: Of feedbacks and crosstalks
-
Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and crosstalks. Oncogene 27, 5527-5541 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 5527-5541
-
-
Carracedo, A.1
Pandolfi, P.P.2
-
13
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway. Proc. Natl Acad. Sci. USA 96, 4240-4245 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
14
-
-
0035880788
-
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
-
Smith JS, Tachibana I, Passe SM et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J. Natl Cancer Inst. 93, 1246-1256 (2001).
-
(2001)
J. Natl Cancer Inst
, vol.93
, pp. 1246-1256
-
-
Smith, J.S.1
Tachibana, I.2
Passe, S.M.3
-
15
-
-
7144223432
-
PTEN mutations in gliomas and glioneuronal tumors
-
Duerr EM, Rollbrocker B, Hayashi Y et al. PTEN mutations in gliomas and glioneuronal tumors. Oncogene 16, 2259-2264 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 2259-2264
-
-
Duerr, E.M.1
Rollbrocker, B.2
Hayashi, Y.3
-
16
-
-
0142061145
-
PTEN methylation and expression in glioblastomas
-
Baeza N, Weller M, Yonekawa Y et al. PTEN methylation and expression in glioblastomas. Acta Neuropathol. 106, 479-485 (2003).
-
(2003)
Acta Neuropathol
, vol.106
, pp. 479-485
-
-
Baeza, N.1
Weller, M.2
Yonekawa, Y.3
-
17
-
-
34547432233
-
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
-
Wiencke JK, Zheng S, Jelluma N et al. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neurao Oncol. 9, 271-279 (2007).
-
(2007)
Neurao Oncol
, vol.9
, pp. 271-279
-
-
Wiencke, J.K.1
Zheng, S.2
Jelluma, N.3
-
18
-
-
0041333109
-
The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: Relationship to tumor grade and survival
-
Zhou YH, Tan F, Hess KR, Yung WK. The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival. Clin. Cancer Res. 9, 3369-3375 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 3369-3375
-
-
Zhou, Y.H.1
Tan, F.2
Hess, K.R.3
Yung, W.K.4
-
19
-
-
0345169950
-
PTEN genc mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma
-
Kato H, FujimuraM, Kumabe T et al. PTEN genc mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. J. Clin. Neurosci. 11, 37-41 (2004).
-
(2004)
J. Clin. Neurosci
, vol.11
, pp. 37-41
-
-
Kato, H.1
Fujimura, M.2
Kumabe, T.3
-
20
-
-
0033561655
-
Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
-
Sano T, Lin H, Chen X et al. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res. 59, 1820-1824 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 1820-1824
-
-
Sano, T.1
Lin, H.2
Chen, X.3
-
21
-
-
0035406063
-
PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis
-
Sasaki H, Zlatescu MC, Betensky RA et al. PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am. J. Pathol. 159, 359-367 (2001).
-
(2001)
Am. J. Pathol
, vol.159
, pp. 359-367
-
-
Sasaki, H.1
Zlatescu, M.C.2
Betensky, R.A.3
-
22
-
-
0036094711
-
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
-
Ermoian RP, Furniss CS, Lamborn KR et al. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin. Cancer Res. 8, 1100-1106 (2002).
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 1100-1106
-
-
Ermoian, R.P.1
Furniss, C.S.2
Lamborn, K.R.3
-
23
-
-
33947381317
-
PIK3CA alterations in primary (de novo) and secondary glioblastornas
-
Kita D, Yonekawa Y, Weller M, Ohgaki H. PIK3CA alterations in primary (de novo) and secondary glioblastornas. Acta. Neuropathol. 113, 295-302 (2007).
-
(2007)
Acta. Neuropathol
, vol.113
, pp. 295-302
-
-
Kita, D.1
Yonekawa, Y.2
Weller, M.3
Ohgaki, H.4
-
24
-
-
13944284494
-
Oncogenic mutations of PIK3CA in human cancers
-
Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 3, 1221-1224 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 1221-1224
-
-
Samuels, Y.1
Velculescu, V.E.2
-
25
-
-
33750596946
-
PIK3CA gene mutations in pediatric and adult glioblastorna multiforme
-
Gallia GL, Rand V, Siu IM et al. PIK3CA gene mutations in pediatric and adult glioblastorna multiforme. Mol. Cancer Res. 4, 709-714 (2006).
-
(2006)
Mol. Cancer Res
, vol.4
, pp. 709-714
-
-
Gallia, G.L.1
Rand, V.2
Siu, I.M.3
-
26
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
DOI:10.1038/nature07385 , Epub ahead of print
-
McLendon R. Friedman A, Bigner D et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature DOI:10.1038/nature07385 (2008) (Epub ahead of print).
-
(2008)
Nature
-
-
McLendon, R.1
Friedman, A.2
Bigner, D.3
-
27
-
-
33947381317
-
PIK3CA alterations in primary (de novo) and secondary glioblastomas
-
Kita. D, Yonekawa Y, Weller M, Ohgaki H. PIK3CA alterations in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 113, 295-302 (2007).
-
(2007)
Acta Neuropathol
, vol.113
, pp. 295-302
-
-
Kita, D.1
Yonekawa, Y.2
Weller, M.3
Ohgaki, H.4
-
28
-
-
0023429079
-
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
-
Wang AJ, Bigner SH, Bigner DD et al. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl Acad. Sci. USA 84(19), 6899-6903 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, Issue.19
, pp. 6899-6903
-
-
Wang, A.J.1
Bigner, S.H.2
Bigner, D.D.3
-
29
-
-
0342627798
-
Amplified cellular oncogenes in neoplasms of the human central nervous system
-
Fuller GN, Bigner SH. Amplified cellular oncogenes in neoplasms of the human central nervous system. Mutat. Res. 276, 299-306 (1992).
-
(1992)
Mutat. Res
, vol.276
, pp. 299-306
-
-
Fuller, G.N.1
Bigner, S.H.2
-
30
-
-
3042581834
-
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
-
Li B, Yuan M, Kim IA et al. Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin. Oncogene 23, 4594-4602 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 4594-4602
-
-
Li, B.1
Yuan, M.2
Kim, I.A.3
-
31
-
-
31544474851
-
Phase I study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
-
Prados MD, Lamborn KR, Chang S et al. Phase I study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. Neuro Oncol. 8, 67-78 (2006).
-
(2006)
Neuro Oncol
, vol.8
, pp. 67-78
-
-
Prados, M.D.1
Lamborn, K.R.2
Chang, S.3
-
32
-
-
33750002725
-
Phase II study of erlotinib single agent therapy in recurrent glioblastoma
-
Vogelbaum MA, Peereboom. DM, Stevens G et al. Phase II study of erlotinib single agent therapy in recurrent glioblastoma. Eur. J. Cancer 3(Suppl.), 135 (2005).
-
(2005)
Eur. J. Cancer
, vol.3
, Issue.SUPPL.
, pp. 135
-
-
Vogelbaum, M.A.1
Peereboom, D.M.2
Stevens, G.3
-
33
-
-
16844384784
-
A Phase II trial of erlotinib (OSI-774) patients with recurrent malignant gliomas (MG) not on EIAEDs
-
Raizer J, Abrey, LE, Wen T et al. A Phase II trial of erlotinib (OSI-774) patients with recurrent malignant gliomas (MG) not on EIAEDs. Am. Soc. Clin. Oncol. Annu. Meet. 22, 1502 (2004).
-
(2004)
Am. Soc. Clin. Oncol. Annu. Meet
, vol.22
, pp. 1502
-
-
Raizer, J.1
Abrey, L.E.2
Wen, T.3
-
34
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T et al. Phase II trial of gefitinib in recurrent glioblastoma. J. Clin. Oncol. 22, 133-142 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
-
35
-
-
0242349431
-
Phase I-II study of ZD-1839 for recurrent malignant gliomas and meningiomas progressing after radiation therapy
-
Lieberman F, Qoughesy T, Malkin M et al. Phase I-II study of ZD-1839 for recurrent malignant gliomas and meningiomas progressing after radiation therapy. Proc. Am. Soc. Clin. Oncol. 22, 105 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol
, vol.22
, pp. 105
-
-
Lieberman, F.1
Qoughesy, T.2
Malkin, M.3
-
36
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff IK, Wang MY, Vivanco I et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
-
37
-
-
26444495517
-
Biomarkers to predict response to epidermal growth factor receptor inhibitors
-
Haas-Kogan DA, Prados MD, Lamborn KR et al. Biomarkers to predict response to epidermal growth factor receptor inhibitors. Cell Cycle 4, 1369-1372 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 1369-1372
-
-
Haas-Kogan, D.A.1
Prados, M.D.2
Lamborn, K.R.3
-
38
-
-
21444450373
-
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
-
Haas-Kogan DA, Prados MD, Tihan T et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J. Natl. Cancer Inst. 97, 880-887 (2005).
-
(2005)
J. Natl. Cancer Inst
, vol.97
, pp. 880-887
-
-
Haas-Kogan, D.A.1
Prados, M.D.2
Tihan, T.3
-
39
-
-
60849131184
-
-
Van Den Bent MJ BA, Rampling R, Kouwenhoven M et al. Randomized Phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26034. Proc. Am. Soc. Clin. Oncol. 25, 2005 (2007).
-
Van Den Bent MJ BA, Rampling R, Kouwenhoven M et al. Randomized Phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26034. Proc. Am. Soc. Clin. Oncol. 25, 2005 (2007).
-
-
-
-
40
-
-
34247218483
-
Gefitinib in patients with progressive high-grade gliomas: A multicentre Phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia. (GICNO)
-
Franceschi E, Cavallo G, Lonardi S et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre Phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia. (GICNO). Br. J. Cancer 96, 1047-1051 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1047-1051
-
-
Franceschi, E.1
Cavallo, G.2
Lonardi, S.3
-
41
-
-
50649103493
-
Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma
-
de Groot JF, Gilbert MR, Aldape K et al. Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma. J. Neurooncol. 90(1), 89-97 (2008).
-
(2008)
J. Neurooncol
, vol.90
, Issue.1
, pp. 89-97
-
-
de Groot, J.F.1
Gilbert, M.R.2
Aldape, K.3
-
42
-
-
60849132393
-
-
Brown PD KS, Sarkaria J, Wu W et al. A Phase II trial (N0177) of erlotinib and temozolomide (TMZ) combined with radiation therapy (RT) in glioblastoma multiforme (GBM). J. Clin. Oncol. 26(20 Suppl.) Abstract 2016 (2008).
-
Brown PD KS, Sarkaria J, Wu W et al. A Phase II trial (N0177) of erlotinib and temozolomide (TMZ) combined with radiation therapy (RT) in glioblastoma multiforme (GBM). J. Clin. Oncol. 26(20 Suppl.) Abstract 2016 (2008).
-
-
-
-
43
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
44
-
-
23844457178
-
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
-
Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res. 65, 7429-7435 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 7429-7435
-
-
Momota, H.1
Nerio, E.2
Holland, E.C.3
-
45
-
-
0034987702
-
Malignant glioma: Genetics and biology of a grave matter
-
Maher EA, Furnari FB, Bachoo RM et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15, 1311-1333 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 1311-1333
-
-
Maher, E.A.1
Furnari, F.B.2
Bachoo, R.M.3
-
46
-
-
1142287357
-
Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: P13K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis
-
Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: P13K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis. Expert Rev. Anticancer Ther. 4, 105-128 (2004).
-
(2004)
Expert Rev. Anticancer Ther
, vol.4
, pp. 105-128
-
-
Newton, H.B.1
-
47
-
-
0036385637
-
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
-
Martin KA, Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv. Cancer Res. 86, 1-39 (2002).
-
(2002)
Adv. Cancer Res
, vol.86
, pp. 1-39
-
-
Martin, K.A.1
Blenis, J.2
-
48
-
-
0034644525
-
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 103, 253-262 (2000).
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 103, 253-262 (2000).
-
-
-
-
49
-
-
5444260577
-
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs
-
Chang SM, Kuhn J, Wen P et al. Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs. Invest. New Drugs 22, 427-435 (2004).
-
(2004)
Invest. New Drugs
, vol.22
, pp. 427-435
-
-
Chang, S.M.1
Kuhn, J.2
Wen, P.3
-
50
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group study
-
Galanis E, Buckner JC, Maurer MJ et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group study. J. Clin. Oncol. 23, 5294-5304 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
-
51
-
-
38849208347
-
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
-
Cloughesy TF, Yoshimoto K, Nghiemphu P et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 5, e8 (2008).
-
(2008)
PLoS Med
, vol.5
-
-
Cloughesy, T.F.1
Yoshimoto, K.2
Nghiemphu, P.3
-
52
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
53
-
-
33746622984
-
Strategies for optimizing combinations of molecularly targeted anticancer agents
-
Dancey JE, Chen HX. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat. Rev. Drug Discov. 5, 649-659 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
54
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83-95 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
-
55
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh JJ, Desjard ins A, Herndon JE 2nd et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin. Cancer Res. 13, 1253-1259 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjard ins, A.2
Herndon 2nd, J.E.3
-
56
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol. 25, 4722-4729 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon 2nd, J.E.3
-
57
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in anti-angiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in anti-angiogenic therapy. Science 307, 58-62 (2005).
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
58
-
-
33748058820
-
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells
-
Wang MY, Lu KV, Zhu S et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res. 66, 7864-7869 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 7864-7869
-
-
Wang, M.Y.1
Lu, K.V.2
Zhu, S.3
-
59
-
-
32944478030
-
Phase I trial of gefitinib plus sirolimus in adults with recurrent malignant glioma
-
Reardon DA, Quinn JA, Vredenburgh JJ et al. Phase I trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin. Cancer Res. 12, 860-868 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 860-868
-
-
Reardon, D.A.1
Quinn, J.A.2
Vredenburgh, J.J.3
-
60
-
-
33746807790
-
Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
-
Doherty L, Gigas DC, Kesari S et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 67, 156-158 (2006).
-
(2006)
Neurology
, vol.67
, pp. 156-158
-
-
Doherty, L.1
Gigas, D.C.2
Kesari, S.3
-
61
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-IR-dependent mechanism
-
Wan X, Harkavy B, Shen N et al. Rapamycin induces feedback activation of Akt signaling through an IGF-IR-dependent mechanism. Oncogene 26, 1932-1940 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
-
62
-
-
34248136479
-
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
-
Liu TJ, LaFortune T, Honda T et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol. Cancer Ther. 6, 1357-1367 (2007).
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 1357-1367
-
-
Liu, T.J.1
LaFortune, T.2
Honda, T.3
-
63
-
-
14044253040
-
Combining radiation and molecular targeting in cancer therapy
-
Camphausen K, Tofilon PJ. Combining radiation and molecular targeting in cancer therapy. Cancer Biol. Ther. 3, 247-250 (2004).
-
(2004)
Cancer Biol. Ther
, vol.3
, pp. 247-250
-
-
Camphausen, K.1
Tofilon, P.J.2
-
64
-
-
1242270613
-
The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: A review of preclinical and correlative clinical data
-
Chakravarti A, Dicker A, Mehta M. The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data. Int. J. Radiat. Oncol. Biol. Phys. 58, 927-931. (2004).
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys
, vol.58
, pp. 927-931
-
-
Chakravarti, A.1
Dicker, A.2
Mehta, M.3
-
65
-
-
20444492764
-
Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors
-
Sartor CI. Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors. Nat. Clin. Pract. Oncol. 1, 80-87 (2004).
-
(2004)
Nat. Clin. Pract. Oncol
, vol.1
, pp. 80-87
-
-
Sartor, C.I.1
-
66
-
-
0036643779
-
Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation
-
Delmas C, Heliez C, Cohen-Jonathan E et al. Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation. Int. J. Cancer 100, 43-48 (2002).
-
(2002)
Int. J. Cancer
, vol.100
, pp. 43-48
-
-
Delmas, C.1
Heliez, C.2
Cohen-Jonathan, E.3
-
67
-
-
33745183568
-
Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of North Central Cancer Treatment Group protocol N0177
-
Krishnan S, Brown PD, Ballman KV et al. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int. J. Radiat. Oncol. Biol. Phys. 65, 1192-1199 (2006).
-
(2006)
Int. J. Radiat. Oncol. Biol. Phys
, vol.65
, pp. 1192-1199
-
-
Krishnan, S.1
Brown, P.D.2
Ballman, K.V.3
-
68
-
-
60849134198
-
An update of Phase II results from RTOG 0211: A Phase I/II study of gefitinib with radiotherapy in newly-diagnosed glioblastoma multiforme
-
Presented at:, Washington, DC, USA, 1-5 April
-
Chakravarti A, Berkey B, Robins HI et al. An update of Phase II results from RTOG 0211: a Phase I/II study of gefitinib with radiotherapy in newly-diagnosed glioblastoma multiforme. Presented at: American Association for Cancer Researcb: 97th Annual Meeting. Washington, DC, USA, 1-5 April 2006.
-
(2006)
American Association for Cancer Researcb: 97th Annual Meeting
-
-
Chakravarti, A.1
Berkey, B.2
Robins, H.I.3
-
69
-
-
23944478922
-
Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma
-
Abstract 1505
-
Uhm JH, Ballman KV, Giannini C et al. Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma. J. Clin. Oncol. 22, 14S (2004) (Abstract 1505).
-
(2004)
J. Clin. Oncol
, vol.22
-
-
Uhm, J.H.1
Ballman, K.V.2
Giannini, C.3
-
70
-
-
33645472347
-
Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
-
Edwards LA, Verreault M, Thiessen B et al. Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells. Mol. Cancer Ther. 5, 645-654 (2006).
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 645-654
-
-
Edwards, L.A.1
Verreault, M.2
Thiessen, B.3
-
71
-
-
0037221440
-
Growth inhibition of human malignant glioma cells induced by the P13-K-specific inhibitor
-
Shingu T, Yamada K, Hara N et al. Growth inhibition of human malignant glioma cells induced by the P13-K-specific inhibitor. J. Neurosury. 98, 154-161 (2003).
-
(2003)
J. Neurosury
, vol.98
, pp. 154-161
-
-
Shingu, T.1
Yamada, K.2
Hara, N.3
-
72
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira. SM, Stauffer F, Brueggen J et al, Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol. Cancer Ther. 7, 1851-1863 (2008).
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
-
73
-
-
51349124367
-
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
-
Ziegler DS, Wright RD, Kesari S et al. Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins. J. Clin. Invest. 118, 3109-3122 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3109-3122
-
-
Ziegler, D.S.1
Wright, R.D.2
Kesari, S.3
-
74
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004).
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
75
-
-
33646382364
-
A dual P13 kinase/mTOR inhibitor reveals emergent efficacy in glioma
-
Fan QW, Knight ZA, Goldenberg DD et al. A dual P13 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9, 341-349 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 341-349
-
-
Fan, Q.W.1
Knight, Z.A.2
Goldenberg, D.D.3
-
76
-
-
34548596728
-
A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
-
Fan QW, Cheng CK, Nicolaides TP et al. A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 67, 7960-7965 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 7960-7965
-
-
Fan, Q.W.1
Cheng, C.K.2
Nicolaides, T.P.3
-
77
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
Stommel JM, Kimmelman AC, Ying H et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318, 287-290 (2007).
-
(2007)
Science
, vol.318
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
-
78
-
-
0038392754
-
Predicting outcome and tailoring treatment in high-grade gliomas
-
Bredel M. Predicting outcome and tailoring treatment in high-grade gliomas. Lancet Oncol. 4, 269-270 (2003).
-
(2003)
Lancet Oncol
, vol.4
, pp. 269-270
-
-
Bredel, M.1
-
79
-
-
33644822862
-
Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas
-
Bredel M, Bredel C, Juric D et al. Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas. J. Clin. Oncol. 24, 274-287 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 274-287
-
-
Bredel, M.1
Bredel, C.2
Juric, D.3
-
81
-
-
0042425741
-
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
-
van den Boom J, Wolter M, Kuick R et al. Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am. J. Pathol. 163, 1033-1043 (2003).
-
(2003)
Am. J. Pathol
, vol.163
, pp. 1033-1043
-
-
van den Boom, J.1
Wolter, M.2
Kuick, R.3
-
82
-
-
33644820339
-
Molecular subclasses of high-grade glionia predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
-
Phillips US, Kharbanda S, Chen R et al. Molecular subclasses of high-grade glionia predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157-173 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 157-173
-
-
Phillips, U.S.1
Kharbanda, S.2
Chen, R.3
-
83
-
-
33751229638
-
Medical management of patients with brain tumors
-
Wen PY, Schiff D, Kesari S et al. Medical management of patients with brain tumors. J. Neurooncol. 80, 313-332 (2006).
-
(2006)
J. Neurooncol
, vol.80
, pp. 313-332
-
-
Wen, P.Y.1
Schiff, D.2
Kesari, S.3
-
84
-
-
22744440362
-
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
-
Loscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog. Neurobiol. 76, 22-76 (2005).
-
(2005)
Prog. Neurobiol
, vol.76
, pp. 22-76
-
-
Loscher, W.1
Potschka, H.2
-
85
-
-
0344520475
-
Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
-
Dai H, Marbach P, Lemaire M et al. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J. Pharmacol. Exp. Ther. 304, 1085-1092 (2003).
-
(2003)
J. Pharmacol. Exp. Ther
, vol.304
, pp. 1085-1092
-
-
Dai, H.1
Marbach, P.2
Lemaire, M.3
-
86
-
-
23444460271
-
Anti-angiogenic therapy for cancer: Current and emerging concepts
-
Jain RK. Anti-angiogenic therapy for cancer: current and emerging concepts. Oncology 19, 7-16 (2005).
-
(2005)
Oncology
, vol.19
, pp. 7-16
-
-
Jain, R.K.1
-
87
-
-
0038476590
-
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. j
-
Ma J, Li S, Reed K et al. Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. j. Pharmacol. Exp. Ther. 305, 833-839 (2003).
-
(2003)
Pharmacol. Exp. Ther
, vol.305
, pp. 833-839
-
-
Ma, J.1
Li, S.2
Reed, K.3
-
88
-
-
0035878997
-
Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470
-
Ma J, Pulfer S, Li S et al. Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470. Cancer Res. 61, 5491-508 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 5491-5508
-
-
Ma, J.1
Pulfer, S.2
Li, S.3
-
89
-
-
40949141801
-
Gallo jM. Impact of angiogenesis inhibition by sunitinib on tumor distribunon of temozolomide
-
Zhou Q, Guo P, Gallo jM. Impact of angiogenesis inhibition by sunitinib on tumor distribunon of temozolomide. Clin. Cancer Res. 14, 1540-1549 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 1540-1549
-
-
Zhou, Q.1
Guo, P.2
|