EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells

Toxicology and Applied Pharmacology

Volumn 235, Issue 3, 2009, Pages 321-328

  Rodríguez Fragoso, Lourdes ^a   Melendez, Karla ^b   Hudson, Laurie G ^b   Lauer, Fredine T ^b   Burchiel, Scott W ^b  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Benzo a pyrene; EGFR; Phosphorylation; PLC ; STAT

Indexed keywords

BENZO[A]PYRENE 1,6 DIONE; BENZO[A]PYRENE 3,6 DIONE; BENZO[A]PYRENE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHOLIPASE C GAMMA1; PHOSPHOTYROSINE; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CARCINOGENICITY; CELL CULTURE; CELL NUCLEUS; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MCF 10A CELL; MUTAGENICITY; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

BENZOPYRENES; CELL LINE, TRANSFORMED; EPITHELIAL CELLS; HUMANS; MAMMARY GLANDS, HUMAN; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 60749123841     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.022     Document Type: Article

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