-
1
-
-
0003473269
-
Seocalcitol (EB 1089): A vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation
-
Hansen, C.M.; Hamberg, K.J.; Binderup, E.; Binderup, L. Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation. Curr Pharm Des 2000, 6(7), 803-828.
-
(2000)
Curr Pharm Des
, vol.6
, Issue.7
, pp. 803-828
-
-
Hansen, C.M.1
Hamberg, K.J.2
Binderup, E.3
Binderup, L.4
-
2
-
-
85047685002
-
Antiproliferative effects of 1alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells
-
Bernardi, R.J.; Johnson, C.S.; Modzelewski, R.A.; Trump, D.L. Antiproliferative effects of 1alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells. Endocrinol 2002, 143(7), 2508-2514.
-
(2002)
Endocrinol
, vol.143
, Issue.7
, pp. 2508-2514
-
-
Bernardi, R.J.1
Johnson, C.S.2
Modzelewski, R.A.3
Trump, D.L.4
-
3
-
-
21344441048
-
-
Ordonez-Moran, P; Larriba, M.J.; Pendas-Franco, N.; Aguilera, O.; Gonzalez-Sancho, J.M.; Munoz, A. Vitamin D and cancer: an update of in vitro and in vivo data. Front Biosci 2005, 10, 2723-2749.
-
Ordonez-Moran, P; Larriba, M.J.; Pendas-Franco, N.; Aguilera, O.; Gonzalez-Sancho, J.M.; Munoz, A. Vitamin D and cancer: an update of in vitro and in vivo data. Front Biosci 2005, 10, 2723-2749.
-
-
-
-
4
-
-
26944461665
-
1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells
-
Fernandez-Garcia, N.I.; Palmer, H.G.; Garcia, M.; Gonzalez-Martin, A.; del Rio, M.; Barettino, D.; et al. 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. Oncogene. 2005, 24(43), 6533-6544.
-
(2005)
Oncogene
, vol.24
, Issue.43
, pp. 6533-6544
-
-
Fernandez-Garcia, N.I.1
Palmer, H.G.2
Garcia, M.3
Gonzalez-Martin, A.4
del Rio, M.5
Barettino, D.6
-
5
-
-
27144503701
-
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
-
Hoyer-Hansen, M.; Bastholm, L.; Mathiasen, I.S.; Elling, F.; Jaattela, M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005, 12(10), 1297-1309.
-
(2005)
Cell Death Differ
, vol.12
, Issue.10
, pp. 1297-1309
-
-
Hoyer-Hansen, M.1
Bastholm, L.2
Mathiasen, I.S.3
Elling, F.4
Jaattela, M.5
-
6
-
-
0642336649
-
Evaluation of vitamin D analogs as therapeutic agents for prostate cancer
-
Chen, T.C.; Holick, M.F.; Lokeshwar, B.L.; Burnstein, K.L.; Schwartz, G.G. Evaluation of vitamin D analogs as therapeutic agents for prostate cancer. Recent Results Cancer Res. 2003, 164, 273-288.
-
(2003)
Recent Results Cancer Res
, vol.164
, pp. 273-288
-
-
Chen, T.C.1
Holick, M.F.2
Lokeshwar, B.L.3
Burnstein, K.L.4
Schwartz, G.G.5
-
7
-
-
0037292450
-
Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation
-
Takahashi, H.; Ibe, M.; Kinouchi, M.; Ishida-Yamamoto, A.; Hashimoto, Y.; Iizuka, H. Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation. J Dermatol Sci 2003, 31(1), 21-28.
-
(2003)
J Dermatol Sci
, vol.31
, Issue.1
, pp. 21-28
-
-
Takahashi, H.1
Ibe, M.2
Kinouchi, M.3
Ishida-Yamamoto, A.4
Hashimoto, Y.5
Iizuka, H.6
-
8
-
-
0035253840
-
Suppressive effect of 1,25-dihydroxyvitamin D3 and its analogues EB 1089 and KH 1060 on T lymphocyte proliferation in active ulcerative colitis
-
Stio, M.; Bonanomi, A.G.; d'Albasio, G.; Treves, C. Suppressive effect of 1,25-dihydroxyvitamin D3 and its analogues EB 1089 and KH 1060 on T lymphocyte proliferation in active ulcerative colitis. Biochem Pharmacol 2001, 61(3), 365-371.
-
(2001)
Biochem Pharmacol
, vol.61
, Issue.3
, pp. 365-371
-
-
Stio, M.1
Bonanomi, A.G.2
d'Albasio, G.3
Treves, C.4
-
9
-
-
26444577470
-
EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer
-
Milliken, E.L.; Zhang, X.; Flask, C.; Duerk, J.L.; MacDonald, P.N.; Keri, R.A. EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer. Cancer Lett 2005, 229(2), 205-215.
-
(2005)
Cancer Lett
, vol.229
, Issue.2
, pp. 205-215
-
-
Milliken, E.L.1
Zhang, X.2
Flask, C.3
Duerk, J.L.4
MacDonald, P.N.5
Keri, R.A.6
-
10
-
-
3042596812
-
Breast cancer cell regulation by high-dose Vitamin D compounds in the absence of nuclear vitamin D receptor
-
Valrance, M.E.; Welsh, J. Breast cancer cell regulation by high-dose Vitamin D compounds in the absence of nuclear vitamin D receptor. J. Steroid Biochem. Mol Biol 2004, 89-90(1-5), 221-225.
-
(2004)
J. Steroid Biochem. Mol Biol
, vol.89-90
, Issue.1-5
, pp. 221-225
-
-
Valrance, M.E.1
Welsh, J.2
-
11
-
-
0029024015
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
-
Pagano, M.; Tam, S.W.; Theodoras, A.M.; Beer-Romero, P.; Del Sal, G.; Chau, V.; et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995, 269(5224), 682-685.
-
(1995)
Science
, vol.269
, Issue.5224
, pp. 682-685
-
-
Pagano, M.1
Tam, S.W.2
Theodoras, A.M.3
Beer-Romero, P.4
Del Sal, G.5
Chau, V.6
-
12
-
-
33846939567
-
Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms
-
Chen, T.P.; Chen, C.M.; Chang, H.W.; Wang, J.S.; Chang, W.C.; Hsu, S.I.; et al. Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms. Gynecol Oncol 2007, 104(3), 516-523.
-
(2007)
Gynecol Oncol
, vol.104
, Issue.3
, pp. 516-523
-
-
Chen, T.P.1
Chen, C.M.2
Chang, H.W.3
Wang, J.S.4
Chang, W.C.5
Hsu, S.I.6
-
13
-
-
16844362291
-
Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism
-
Wang, C.; Hou, X.; Mohapatra, S.; Ma, Y.; Cress, W.D.; Pledger, W.J.; et al. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. J Biol Chem 2005, 280(13), 12339-12343.
-
(2005)
J Biol Chem
, vol.280
, Issue.13
, pp. 12339-12343
-
-
Wang, C.1
Hou, X.2
Mohapatra, S.3
Ma, Y.4
Cress, W.D.5
Pledger, W.J.6
-
14
-
-
0030736420
-
Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase
-
Huang, C.; Ma, W.; Ding, M.; Bowden, G.T.; Dong, Z. Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase. J Biol Chem 1997, 272(44), 27753-27757.
-
(1997)
J Biol Chem
, vol.272
, Issue.44
, pp. 27753-27757
-
-
Huang, C.1
Ma, W.2
Ding, M.3
Bowden, G.T.4
Dong, Z.5
-
15
-
-
27144482083
-
Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes
-
Ouyang, W.; Ma, Q.; Li, J.; Zhang, D.; Liu, Z.G.; Rustgi, A.K.; et al. Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes. Cancer Res 2005, 65(20), 9287-9293.
-
(2005)
Cancer Res
, vol.65
, Issue.20
, pp. 9287-9293
-
-
Ouyang, W.1
Ma, Q.2
Li, J.3
Zhang, D.4
Liu, Z.G.5
Rustgi, A.K.6
-
16
-
-
0142244118
-
p27 as a target for cancer therapeutics
-
Blain, S.W.; Scher, H.I.; Cordon-Cardo, C.; Koff, A. p27 as a target for cancer therapeutics. Cancer Cell 2003, 3(2), 111-115.
-
(2003)
Cancer Cell
, vol.3
, Issue.2
, pp. 111-115
-
-
Blain, S.W.1
Scher, H.I.2
Cordon-Cardo, C.3
Koff, A.4
-
17
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
Carrano, A.C.; Eytan, E.; Hershko, A.; Pagano, M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Bio 1999, 1(4), 193-199.
-
(1999)
Nature Cell Bio
, vol.1
, Issue.4
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
18
-
-
0033174070
-
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
-
Sutterluty, H.; Chatelain, E.; Marti, A.; et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nature Cell Biol 1999, 1(4), 207-214.
-
(1999)
Nature Cell Biol
, vol.1
, Issue.4
, pp. 207-214
-
-
Sutterluty, H.1
Chatelain, E.2
Marti, A.3
-
19
-
-
0001208875
-
Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells
-
Wang, Q.M.; Jones, J.B.; Studzinski, G.P. Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells. Cancer Res 1996, 56(2), 264-267.
-
(1996)
Cancer Res
, vol.56
, Issue.2
, pp. 264-267
-
-
Wang, Q.M.1
Jones, J.B.2
Studzinski, G.P.3
-
20
-
-
2942588521
-
p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/ Skp2 ubiquitin ligase
-
Li, P.; Li, C.; Zhao, X.; Zhang, X.; Nicosia, S.V.; Bai, W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/ Skp2 ubiquitin ligase. J Biol Chem 2004, 279(24), 25260-25267.
-
(2004)
J Biol Chem
, vol.279
, Issue.24
, pp. 25260-25267
-
-
Li, P.1
Li, C.2
Zhao, X.3
Zhang, X.4
Nicosia, S.V.5
Bai, W.6
-
21
-
-
33847390758
-
Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis
-
Flynn, G.; Chung, I.; Yu, W.D.; Romano, M.; Modzelewski, R.A.; Johnson, C.S.; et al. Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis. Oncol 2006, 70(6), 447-457.
-
(2006)
Oncol
, vol.70
, Issue.6
, pp. 447-457
-
-
Flynn, G.1
Chung, I.2
Yu, W.D.3
Romano, M.4
Modzelewski, R.A.5
Johnson, C.S.6
-
22
-
-
33747044905
-
1,25(OH)2Vitamin D3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck
-
Gedlicka, C.; Hager, G.; Weissenbock, M.; Gedlicka, W.; Knerer, B.; Kornfehl, J.; et al. 1,25(OH)2Vitamin D3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck. J Oral Pathol Med 2006, 35(8), 472-478.
-
(2006)
J Oral Pathol Med
, vol.35
, Issue.8
, pp. 472-478
-
-
Gedlicka, C.1
Hager, G.2
Weissenbock, M.3
Gedlicka, W.4
Knerer, B.5
Kornfehl, J.6
-
23
-
-
33847343428
-
Antitumor effects of two less-calcemic vitamin D analogs (Paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells
-
Alagbala, A.A.; Johnson, C.S.; Trump, D.L.; Posner, G.H.; Foster, B.A. Antitumor effects of two less-calcemic vitamin D analogs (Paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells. Oncol 2006, 70(6), 483-492.
-
(2006)
Oncol
, vol.70
, Issue.6
, pp. 483-492
-
-
Alagbala, A.A.1
Johnson, C.S.2
Trump, D.L.3
Posner, G.H.4
Foster, B.A.5
-
24
-
-
0037372015
-
Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells
-
Lin, R.; Wang, T.T.; Miller, W.H. Jr.; White, J.H. Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells. Endocrinol 2003, 144(3), 749-753.
-
(2003)
Endocrinol
, vol.144
, Issue.3
, pp. 749-753
-
-
Lin, R.1
Wang, T.T.2
Miller Jr., W.H.3
White, J.H.4
-
25
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres, M.; Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nature Rev 2001, 1(3), 222-231.
-
(2001)
Nature Rev
, vol.1
, Issue.3
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
26
-
-
0032511848
-
The murine gene p27Kip1 is haplo-insufficient for tumour suppression
-
Fero, M.L.; Randel, E.; Gurley, K.E.; Roberts, J.M.; Kemp, C.J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 1998, 396(6707), 177-180.
-
(1998)
Nature
, vol.396
, Issue.6707
, pp. 177-180
-
-
Fero, M.L.1
Randel, E.2
Gurley, K.E.3
Roberts, J.M.4
Kemp, C.J.5
-
27
-
-
0032696891
-
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells
-
Baldassarre, G.; Belletti, B.; Bruni, P.; Boccia, A.; Trapasso, F.; Pentimalli, F.; et al. Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells. J Clin Invest 1999, 104(7), 865-874.
-
(1999)
J Clin Invest
, vol.104
, Issue.7
, pp. 865-874
-
-
Baldassarre, G.1
Belletti, B.2
Bruni, P.3
Boccia, A.4
Trapasso, F.5
Pentimalli, F.6
-
28
-
-
0036894711
-
-
Kullmann, M.; Gopfert, U.; Siewe, B.; Hengst, L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR. Genes & Dev 2002, 16(23), 3087-3099.
-
Kullmann, M.; Gopfert, U.; Siewe, B.; Hengst, L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR. Genes & Dev 2002, 16(23), 3087-3099.
-
-
-
-
30
-
-
0035265829
-
A CDK-independent function of mammalian Cks1: Targeting of SCF(Skp2) to the CDK inhibitor p27Kip1
-
Spruck, C.; Strohmaier, H.; Watson, M.; Smith, A.P.; Ryan, A.; Krek, T.W.; et al. A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Molecular Cell 2001, 7(3), 639-650.
-
(2001)
Molecular Cell
, vol.7
, Issue.3
, pp. 639-650
-
-
Spruck, C.1
Strohmaier, H.2
Watson, M.3
Smith, A.P.4
Ryan, A.5
Krek, T.W.6
-
31
-
-
0033578073
-
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
-
Jun 17
-
Tsvetkov, L.M.; Yeh, K.H.; Lee, S.J.; Sun, H.; Zhang, H. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 1999 Jun 17, 9(12), 661-664.
-
(1999)
Curr Biol
, vol.9
, Issue.12
, pp. 661-664
-
-
Tsvetkov, L.M.1
Yeh, K.H.2
Lee, S.J.3
Sun, H.4
Zhang, H.5
-
32
-
-
0035942224
-
Skp2 is oncogenic and overexpressed in human cancers
-
Gstaiger, M.; Jordan, R.; Lim, M.; Catzavelos, C.; Mestan, J.; Slingerland, J.; et al. Skp2 is oncogenic and overexpressed in human cancers. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(9), 5043-5048.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5043-5048
-
-
Gstaiger, M.1
Jordan, R.2
Lim, M.3
Catzavelos, C.4
Mestan, J.5
Slingerland, J.6
-
33
-
-
0035476237
-
High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas
-
Kudo, Y.; Kitajima, S.; Sato, S.; Miyauchi, M.; Ogawa, I.; Takata, T. High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. Cancer Res 2001, 61(19), 7044-7047.
-
(2001)
Cancer Res
, vol.61
, Issue.19
, pp. 7044-7047
-
-
Kudo, Y.1
Kitajima, S.2
Sato, S.3
Miyauchi, M.4
Ogawa, I.5
Takata, T.6
-
34
-
-
2342500360
-
The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
-
Lu, L.; Schulz, H.; Wolf, D.A. The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. BMC Cell Bio 2002, 20(3), 22.
-
(2002)
BMC Cell Bio
, vol.20
, Issue.3
, pp. 22
-
-
Lu, L.1
Schulz, H.2
Wolf, D.A.3
-
35
-
-
0035956971
-
Role of the F-box protein Skp2 in lymphomagenesis
-
Latres, E.; Chiarle, R.; Schulman, B.A.; Pavletich, N.P.; Pellicer, A.; Inghirami, G.; et al. Role of the F-box protein Skp2 in lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(5), 2515-2520.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.5
, pp. 2515-2520
-
-
Latres, E.1
Chiarle, R.2
Schulman, B.A.3
Pavletich, N.P.4
Pellicer, A.5
Inghirami, G.6
|