Production and localization of recombinant pharmaceuticals in transgenic seeds

Methods in Molecular Biology

Volumn 483, Issue , 2009, Pages 69-87

  Rademacher, Thomas ^a   Arcalis, Elsa ^a   Stoger, Eva ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cereals protein bodies storage organelles; DsRed; Endosperm; Fluorescent protein; Immunofluorescence immunogold; Microscopy; Transgenic maize seeds

Indexed keywords

ZEA MAYS;

DRUG; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; GENETICS; METABOLISM; PLANT SEED; TRANSGENIC PLANT;

PHARMACEUTICAL PREPARATIONS; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; SEEDS;

EID: 60549113714     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-407-0_5     Document Type: Article

References (43)

1. J.K. Ma, Drake, P.M., Christou, P. (2003) The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet. 4, 794-805.
2. Ma, J.K., Chikwamba, R., Sparrow, P., Fischer, R., Mahoney, R., Twyman, R.M. (2005) Plant-derived pharmaceuticals-the road forward. Trends Plant Sci. 10, 580-585.
3. Whaley, K.J., Zeitlin, L. (2005) Preventing transmission: plant-derived microbicides and mucosal vaccines for reproductive health. Vaccine 23, 1819-1822.
4. Stoger, E., Sack, M., Nicholson, L., Fischer, R., Christou, P. (2005) Recent Progress in Plantibody Technology. J. Curr. Pharm. Des. 11, 2439-2457.
5. Stoger, E., Sack, M., Perrin, Y., Vaquero, C., Torres, E., Twyman, R.M., Christou, P., Fischer, R. (2002) Practical considerations for pharmaceutical antibody production in different crop systems. Mol. Breed. 9, 149-158.
6. Stoger, E., Ma, J.K.C., Fischer, R., Christou, P. (2005) Sowing the seeds of success: pharmaceutical proteins from plants. Curr. Opin. Biotechnol. 16, 167-173.
7. Hood, E.E., Witcher, D.R., Maddock, S., Meyer, T., Baszczynski, C., Bailey, M., Flynn, P., Register, J., Marshall, L., Bond, D. et al.. (1997) Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification. Mol. Breed. 3, 291-306.
8. Witcher, D.R., Hood, E.E., Peterson, D., Bailey, M., Bond, D., Kusnadi, A., Evangelista, R., Nikolov, Z., Wooge, C., Mehigh, R. et al.. (1998) Commercial production of b-glucuronidase (GUS): a model system for the production of proteins in plants. Mol. Breed. 4, 301-312.
9. Chikwamba, R.K., Scott, M.P., Mejia, L.B., Mason, H.S., Wang, K. (2003) Localization of a bacterial protein in starch granules of transgenic maize kernels. Proc. Natl. Acad. Sci. USA 100, 11127-11132.
10. Yang, D.C., Guo, F.L., Liu, B., Huang, N., Watkins, S.C. (2003) Expression and localization of human lysozyme in the endosperm of transgenic rice. Planta 216, 597-603.
11. Rascon-Cruz, Q., Sinagawa-Garcia, S., Osuna-Castro, J.A., Bohorova, N., Paredes-Lopez, O. (2004) Accumulation, assembly, and digestibility of amarantin expressed in transgenic tropical maize. Theor. Appl. Genet. 108, 335-342.
12. Horvath, H., Huang, J., Wong, O., Kohl, E., Okita, T., Kannangara, C.G., von Wettstein, D. (2000) The production of recombinant proteins in transgenic barley grains. Proc. Natl. Acad. Sci. USA 97, 1914-1919.
13. Alvarez, M.L., Guelman, S., Halford, N.G., Regiardo, M., Ryabuskina, N., Stein, J., Vallejos, R.H. (2000) Silencing of HMW glutelins in transgenic wheat expressing extraHMW subunits. Theor. Appl. Genet. 100, 319-327.
14. Lamacchia, C., Shewry, P.R., Di Fonzo, N., Forsyth, J.L., Harris, N., Lazzeri, P.A., Napier, J.A., Halford, N.G., Barcelo, P. (2001) Endosperm-specific activity of a storage protein gene promoter in transgenic wheat seed. J. Exp. Bot. 52, 243-250.
15. Qu, L.Q., Takaiwa, F. (2004) Tissue specific expression and quantitative potential evaluation of seed storage component gene promoters in transgenic rice. Plant Biotechnol. J. 2, 113-125.
16. Zheng, Z., Kawagoe, Y., Xiao, S., Li, Z., Okita, T., Hau, T.L., Lin, A., Murai, N. (1993) 5′¢ distal and proximal cis-acting regulator elements are required for developmental control of a rice seed storage protein glutelin gene. Plant J. 4, 357-366.
17. Hwang, Y.S., Nichol, S., Nandi, S., Jernstedt, J.A., Huang, N. (2001) Aleurone and embryo-specific expression of the b-glucuronidase gene controlled by the barley Chi26 and Ltp1 promoters in transgenic rice. Plant Cell Rep. 20, 647-654.
18. Philip, R., Darnowski, D.W., Maughan, P.J., Vodkin, L.O. (2001) Processing and localization of bovine b-casein expressed in transgenic soybean seeds under control of a soybean lectin expression cassette. Plant Sci. 161, 323-335.
19. Perrin, Y., Vaquero, C., Gerrard, I., Sack, M., Drossard, J., Stoger, E., Christou, P., Fischer, R. (2000) Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy. Mol. Breed. 6, 345-352.
20. Saalbach, I., Giersberg, M., Conrad, U. (2001) High-level expression of a single-chain Fv fragment (scFv) antibody in transgenic pea seeds. J. Plant Physiol. 158, 529-533.
21. De Jaeger, G., Scheffer, S., Jacobs, A., Zambre, M., Zobell, O., Goossens, A. et al.. (2002) Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences. Nat. Biotechnol. 20, 1265-1268.
22. Moloney, M., Boothe, J., Van Rooijen, G. (2003) Oil bodies and associated proteins as affinity matrices. January 21, 2003; US Patent 6509453.
23. Okita, T.W., Rogers, J.C. (1996) Compartmentation of proteins in the endomembrane system of plant cells. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47, 327-350.
24. Shewry, P.R., Halford, N.G. (2002) Cereal seed storage proteins: structure, properties and role in grain utilization. J. Exp. Bot. 53, 947-958.
25. Vitale, A., Hinz, G. (2005) Sorting of proteins to storage vacuoles: how many mechanisms? Trends Plant Sci. 10, 316-323.
26. Robinson, D.G., Oliviusson, P., Hinz, G. (2005) Protein sorting to the vacuoles of plants: a critical appraisal. Traffic 6, 615-625.
27. Drakakaki, G., Marcel, S., Arcalis, E., Altmann, F., Gonzalez-Melendi, P., Fischer, R., Christou, P., Stoger, E. (2006) The intracellular fate of a recombinant protein is tissuedependent. Plant Physiol. 141, 578-586.
28. Arcalis, E., Marcel, S., Altmann, F., Kolarich, D., Drakakaki, G., Fischer, R., Christou, P., Stoger, E. (2004) Unexpected deposition patterns of recombinant proteins in post-ER compartments of wheat endosperm. Plant Physiol. 136, 3457-3466.
29. Nicholson, L., Gonzalez-Melendi, P., van Dolleweerd, C., Tuck, H., Perrin, Y., Ma, J.K.C., Fischer, R., Christou, P., Stoger, E. (2005) A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol. J. 3, 115-127.
30. Petruccelli, S., Otegui, M.S., Lareu, F., Tran Dinh, O., Fitchette, A.C., Circosta, A., Rumbo, M., Bardor, M., Carcamo, R., Gomord, V., Beachy, R.N. (2006) A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seeds. Plant Biotechnol. J. 4, 511-527.
31. Torres, E., Gonzalez-Melendi, P., Stoger, E., Shaw, P., Twyman, R.M., Nicholson, L., Vaquero, C., Fischer, R., Christou, P., Perrin, Y. (2001) Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in postendoplasmic reticulum compartments. Plant Physiol. 127, 1212-1223.
32. Hood, E.E., Bailey, M.R., Beifuss, K., Magallanes-Lundback, M., Horn, M.E., Callaway, E., Drees, C., Delaney, D.E., Clough, R., Howard, J.A. (2003) Criteria for high-level expression of a fungal laccase gene in transgenic maize. Plant Biotechnol. J. 1, 129-140.
33. Wright, K.E., Prior, F., Sardana, R., Altosaar, I., Dudani, A.K., Ganz, P.R., Tackaberry, E.S. (2001) Sorting of glycoprotein B from human cytomegalovirus to protein storage vesicles in seeds of transgenic tobacco. Transgenic Res. 10, 177-181.
34. Czihal, A., Conrad, B., Buchner, P., Brevis, R., Farouk, A.A., Manteuffel, R., Adler, K., Wobus, U., Hofemeister, J., Baumlein, H. (1999) Gene farming in plants: expression of a heat stable Bacillus amylase in transgenic legume seeds. J. Plant Physiol. 155, 183-189.
35. Munro, S., Pelham, H.R. (1987) A C-terminal signal prevents secretion of luminal ER proteins. Cell 48, 899-907.
36. Conrad, U., Fiedler, U. (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol. Biol. 38, 101-109.
37. Ko, K., Tekoah, Y., Rudd, P.M., Harvey, D.J., Dwek, R.A., Spitsin, S. et-al.. (2003) Function and glycosylation of plant-derived antiviral monoclonal antibody. Proc. Natl. Acad. Sci.USA 100, 8013-8018.
38. Takaiwa, F., Takagi, H., Hirose, S., Wakasa, Y. (2007) Endosperm tissue is good production platform for artificial recombinant proteins in transgenic rice. Plant Biotechnol. J. 5, 84-92.
39. Van Droogenbroeck, B., Cao, J., Stadlmann, J., Altmann, F., Colanesi, S., Hillmer, S., Robinson, D.G., Van Lerberge, E., Terryn, N., Van Montagu, M., Liang, M., Depicker, A., De Jaeger, G. (2007) Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds. Proc. Natl. Acad. Sci. USA 104, 1430-1435.
40. Harper, B.K., Mabon, S.A., Leffel, S.M., Halfhill, M.D., Richards, H.A., Moyer, K.A., Stewart, C.N. Jr (1999) Green fluorescent protein as a marker for expression of a second gene in transgenic plants. Nat. Biotechnol. 17, 1125-1129.
41. Armstrong, C.L., Green, C.E. (1985) Establishment and maintenance of friable, embryogenic maize callus and the involvement of L-proline. Planta 164, 207-214.
42. Armstrong, C.L., Green, C.M., Phillips, R.L. (1991) Development and availability of germplasm with Type II culture formation response. Maize Genet. Coop. Newsletter 65, 92-93.
43. Vain, P., McMullen, M.D., Finer, J.J. (1993). Osmotic treatment enhances particle bombardment-mediated transient and stable transformation of maize. Plant Cell Rep. 12, 84-88.