Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transsgenic Aradidosis seeds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 4, 2007, Pages 1430-1435

  Van Droogenbroeck, Bart ^a   Cao, Jingyuan ^b   Stadlmann, Johannes ^c   Altmann, Friedrich ^c   Colanesi, Sarah ^d   Hillmer, Stefan ^d   Robinson, David G ^d   Van Lerberge, Els ^a   Terryn, Nancy ^e   Van Montagu, Marc ^e   Liang, Mifang ^b   Depicker, Ann ^a   De Jaeger, Geert ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b NATIONAL INSTITUTE FOR VIRAL DISEASE CONTROL AND PREVENTION   (China)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

Glycosylation; Molecular farming; Recombinant antibody; Subcellular localization

Indexed keywords

BINDING PROTEIN; CALRETICULIN; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT ANTIBODY; SINGLE CHAIN FC ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARABIDOPSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL WALL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; GLYCOSYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT SEED; PRIORITY JOURNAL; PROTEIN TARGETING; TRANSGENIC PLANT;

ARABIDOPSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; PEPTIDE MAPPING; PLANTIBODIES; PLANTS, GENETICALLY MODIFIED; TRYPSIN;

ARABIDOPSIS THALIANA; HEPATITIS A VIRUS; MAMMALIA;

EID: 33846614234     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609997104     Document Type: Article

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