Clonal analysis of hematopoiesis-supporting activity of human mesenchymal stem cells in association with Jagged1 expression and osteogenic potential

Cell Transplantation

Volumn 17, Issue 10-11, 2008, Pages 1169-1179

  Fujita, Satoshi ^a,b   Toguchida, Junya ^a   Morita, Yutaka ^c   Iwata, Hiroo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Itabashi Chuo Medical Center   (Japan)

^c Itabashi Chuo Medical Center   (Japan)

Author keywords

Cell transplantation; Expansion; Hematopoietic stem cell; Mesenchymal stem cell; Umbilical cord blood

Indexed keywords

JAGGED1; MESSENGER RNA; NOTCH RECEPTOR; CALCIUM; CALCIUM BINDING PROTEIN; CD34 ANTIGEN; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CD34 SELECTION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD; CELL CLONE; CELL CULTURE; COCULTURE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; PHYSIOLOGY;

ANTIGENS, CD34; CALCIUM; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CLONE CELLS; COCULTURE TECHNIQUES; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEMATOPOIESIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MESENCHYMAL STEM CELLS; OSTEOGENESIS;

EID: 60549112409     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908787236611     Document Type: Article

References (40)

1. Adams, G. B.; Chabner, K. T.; Alley, I. R.; Olson, D. P.; Szczepiorkowski, Z. M.; Poznansky, M. C.; Kos, C. H.; Pollak, M. R.; Brown, E. M.; Scadden, D. T. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439:599-603; 2006.
2. Amos, T. A. S.; Gordon, M. Y. Sources of human hematopoietic stem cells for transplantation - a review. Cell Transplant. 4:547-569; 1995.
3. Androutsellis-Theotokis, A.; Leker, R. R.; Soldner, F.; Hoeppner, D. J.; Ravin, R.; Poser, S. W.; Rueger, M. A.; Bae, S. K.; Kittappa, R.; McKay, R. D. G. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442:823-826; 2006.
4. Arai, F.; Hirao, A.; Ohmura, M.; Sato, H.; Matsuoka, S.; Takubo, K.; Ito, K.; Koh, G.; Suda, T. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118:149-161; 2004.
5. Breems, D. A.; Blokland, E. A. W.; Neben, S.; Ploemacher, R. E. Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. Leukemia 8:1095-1104; 1994.
6. Calvi, L. M.; Adams, G. B.; Weibrecht, K. W.; Weber, J. M.; Olson, D. P.; Knight, M. C.; Martin, R. P.; Schipani, E.; Divieti, P.; Bringhurst, F. R.; Milner, L. A.; Kronenberg, H. M.; Scadden, D. T. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425:841-846; 2003.
7. Digirolamo, C. M.; Stokes, D.; Colter, D.; Phinney, D. G.; Class, R.; Prockop, D. J. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br. J. Haematol. 107: 275-281; 1999.
8. Ducy, P.; Zhang, R.; Geoffroy, V.; Ridall, A. L.; Karsenty, G. Osf2/Cbfal: A transcriptional activator of osteoblast differentiation. Cell 89:747-754; 1997.
9. Flynn, D. M.; Nijjar, S.; Hubscher, S. G.; de Goyet, J. D.; Kelly, D. A.; Strain, A. J.; Crosby, H. A. The role of Notch receptor expression in bile duct development and disease. J. Pathol. 204:55-64; 2004.
10. Fujimoto, N.; Fujita, S.; Tsuji, T.; Toguchida, J.; Ida, K.; Suginami, H.; Iwata, H. Microencapsulated feeder cells as a source of soluble factors for expansion of CD34(+) hematopoietic stem cells. Biomaterials 28:4795-4805; 2007.
11. Gronthos, S.; Chen, S.; Wang, C. Y.; Robey, P. G.; Shi, S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J. Bone Miner. Res. 18:716-722; 2003.
12. - cells in cord blood and bone marrow. Blood 86:3745-3753; 1995.
13. Hay, E.; Lemonnier, J.; Modrowski, D.; Lomri, A.; Lasmoles, F.; Marie, P. J. N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2. J. Cell. Physiol. 183:117-128; 2000.
14. Hofmeister, C. C.; Zhang, J.; Knight, K. L.; Le, P.; Stiff, P. J. Ex vivo expansion of umbilical cord blood stem cells for transplantation: Growing knowledge from the hematopoietic niche. Bone Marrow Transplant. 39:11-23; 2007.
15. Huang, Y. Q.; Li, J. J.; Karpatkin, S. Identification of a family of alternatively spliced mRNA species of angiopoietin-1. Blood 95:1993-1999; 2000.
16. in't Anker, P. S.; Noort, W. A.; Scherjon, S. A.; Kleijburg-van der Keur, C.; Kruisselbrink, A. B.; van Bezooijen, R. L.; Beekhuizen, W.; Willemze, R.; Kanhai, H. H.; Fibbe, W. E. Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential. Haematologica 88:845-852; 2003.
17. Javazon, E. H.; Colter, D. C.; Schwarz, E. J.; Prockop, D. J. Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells. Stem Cells 19:219-225; 2001.
18. Kadereit, S.; Deeds, L. S.; Haynesworth, S. E.; Koc, O. N.; Kozik, M. M.; Szekely, E.; Daum-Woods, K.; Goetchius, G. W.; Fu, P.; Welniak, L. A.; Murphy, W. J.; Laughlin, M. J. Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/ CD38(-) early progenitors cultured over human MSCs as a feeder layer. Stem Cells 20:573-582; 2002.
19. Kawano, Y.; Kobune, M.; Yamaguchi, M.; Nakamura, K.; Ito, Y.; Sasaki, K.; Takahashi, S.; Nakamura, T.; Chiba, H.; Sato, T.; Matsunaga, T.; Azuma, H.; Ikebuchi, K.; Ikeda, H.; Kato, J.; Niitsu, Y.; Hamada, H. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood 101:532-540; 2003.
20. Kiyono, T.; Foster, S. A.; Koop, J. I.; McDougall, J. K.; Galloway, D. A.; Klingelhutz, A. J. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88; 1998.
21. Kucia, M.; Ratajczak, J.; Ratajczak, M. Z. Are bone marrow stem cells plastic or heterogenous - that is the question. Exp. Hematol. 33:613-623; 2005.
22. Majumdar, M. K.; Thiede, M. A.; Haynesworth, S. E.; Bruder, S. P.; Gerson, S. L. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J. Hematother. Stem Cell Res. 9:841-848; 2000.
23. Mancini, S. J. C.; Mantei, N.; Dumortier, A.; Suter, U.; MacDonald, H. R.; Radtke, F. Jaggedl-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105:2340-2342; 2005.
24. Milona, M. A.; Gough, J. E.; Edgar, A. J. Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. BMC Genomics 4:43; 2003.
25. Nakashima, K.; Zhou, X.; Kunkel, G.; Zhang, Z.; Deng, J. M.; Behringer, R. R.; De Crombmgghe, B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29; 2002.
26. Nandoe Tewarie, R. D. S.; Hurtado, A.; Levi, A. D. O.; Grotenhuis, J. A.; Oudega, M. Bone marrow stromal cells for repair of the spinal cord: Towards clinical application. Cell Transplant. 15:563-577; 2006.
27. Noort, W. A.; Kruisselbrink, A. B.; in't Anker, P. S.; Kruger, M.; van Bezooijen, R. L.; de Paus, R. A.; Heemskerk, M. H.; Löwik, C. W.; Falkenburg, J. H.; Willemze, R.; Fibbe, W. E. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp. Hematol. 30: 870-878; 2002.
28. Okamoto, T.; Aoyama, T.; Nakayama, T.; Nakamata, T.; Hosaka, T.; Nishijo, K.; Nakamura, T.; Kiyono, T.; Toguchida, J. Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem. Biophys. Res. Commun. 295:354-361; 2002.
29. Pittenger, M. F.; Mackay, A. M.; Beck, S. C.; Jaiswal, R. K.; Douglas, R.; Mosca, J. D.; Moorman, M. A.; Simonetti, D. W.; Craig, S.; Marshak, D. R. Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147; 1999.
30. Ploemacher, R. E.; Van Der Sluijs, J. P.; Voerman, J. S. A.; Brons, N. H. C. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74:2755-2763; 1989.
31. +/381o human marrow cells after in vitro cytokine exposure. Blood 85:1480-1487; 1995.
32. Reya, T.; Duncan, A. W.; Ailles, L.; Domen, J.; Scherer, D. C.; Willert, K.; Hintz, L.; Nusse, R.; Weissman, I. L. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423:409-414; 2003.
33. Rocha, V.; Gluckman, E. Clinical use of umbilical cord blood hematopoietic stem cells. Biol. Blood Marrow Transplant. 12:34-41; 2006.
34. Sutherland, H. J.; Eaves, C. J.; Lansdorp, P. M.; Thacker, J. D.; Hogge, D. E. Differential regulation of primitive human hematopoietic cells in long-term cultures maintained on genetically engineered murine stromal cells. Blood 78:666-672; 1991.
35. Terai, M.; Uyama, T.; Sugiki, T.; Li, X. K.; Umezawa, A.; Kiyono, T. Immortalization of human fetal cells: The life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol. Biol. Cell 16:1491-1499; 2005.
36. Tsuji, T.; Ogasawara, H.; Aoki, Y.; Tsurumaki, Y.; Kodama, H. Characterization of murine stromal cell clones established from bone marrow and spleen. Leukemia 10:803-812; 1996.
37. Tulac, S.; Nayak, N. R.; Kao, L. C.; Van Waes, M.; Huang, J.; Lobo, S.; Germeyer, A.; Lessey, B. A.; Taylor, R. N.; Suchanek, E.; Giudice, L. C. Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. J. Clin. Endocrinol. Metab. 88:3860-3866; 2003.
38. Willert, K.; Brown, J. D.; Danenberg, E.; Duncan, A. W.; Weissman, I. L.; Reya, T.; Yates, 3rd, J. R.; Nusse, R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423:448-452; 2003.
39. Zhang, J.; Niu, C.; Ye, L.; Huang, H.; He, X.; Tong, W. G.; Ross, J.; Haug, J.; Johnson, T.; Feng, J. Q.; Harris, S.; Wiedemann, L. M.; Mishina, Y.; Li, L. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425:836-841; 2003.
40. + cells. Exp. Hematol. 32:657-664; 2004.